Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) ELISA Kits

HSD17B10 encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. Additionally we are shipping HSD17B10 Antibodies (137) and HSD17B10 Proteins (19) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
HSD17B10 3028 Q99714
HSD17B10 15108  
HSD17B10 63864 O70351
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Top HSD17B10 ELISA Kits at antibodies-online.com

Showing 5 out of 11 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 6.25 pg/mL 25-1600 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Details
Mouse 0.063 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests 13 to 16 Days
$757.89
Details
Human
  96 Tests 2 to 3 Days
$380.00
Details
Rat
  96 Tests 11 to 18 Days
$618.29
Details
Cow
  96 Tests 15 to 18 Days
$1,029.60
Details

More ELISA Kits for HSD17B10 Interaction Partners

Human Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) interaction partners

  1. This study proposes low-resolution models of the MRPP1-MRPP2 and MRPP1-MRPP2-MRPP3 complexes that suggest the overall architecture, stoichiometry, and orientation of subunits and tRNA substrates.

  2. 17beta-Hydroxysteroid dehydrogenase type 10 is a multifunctional, homotetrameric, mitochondrial protein encoded by the HSD17B10 gene at Xp 11.2. This protein, 17beta-HSD10, is overexpressed in brain cells of Alzheimer's disease (AD) patients. Analysis of the impact of 17beta-HSD10 and its inhibitor, amyloid-beta peptide (Abeta), on the metabolism of neuroactive steroids offers a new approach to AD pathogenesis.

  3. Authors report two patients with novel missense mutations in the HSD17B10 gene (c.34G>C and c.526G>A), resulting in the p.V12L and p.V176M substitutions. Val12 and Val176 are highly conserved residues located at different regions of the MRPP2 structure.

  4. in addition to being an essential component of the RNase P reaction, MRPP1/2 serves as a processing platform for several down-stream tRNA maturation steps in human mitochondria.

  5. The S-nitrosation of a cysteine residue distal to the 3-hydroxyacyl-CoA dehydrogenase type 2 (HADH2) active site impaired catalytic activity.

  6. A computational study and enzyme inhibition assay with full length human 17-beta-HSD10 identifies risperidone as enzyme inhibitor and possible antineoplastic agent.

  7. Data suggest that HSD10 plays a role in alterations of energy metabolism by regulating mtDNA content in colorectal carcinomas.

  8. upon exposure to E2, ERalpha rapidly localizes to mitochondria, in which it interacts with HSD17B10 to modulate the expression of mitochondrial RNA transcripts.

  9. Our findings demonstrate that overexpression of HSD10 accelerates pheochromocytoma cell growth, enhances cell respiration, and increases cellular resistance to cell death induction.

  10. Three HSD10 variants associated with neurodegenerative disorders are inactive with cardiolipin

  11. The authors demonstrate elevated amounts of unprocessed pre-tRNAs and mRNA transcripts encoding mitochondrial subunits indicating deficient RNase P activity in HSD10 disease.

  12. The study showed that pathogenic mutations impair SDR5C1-dependent dehydrogenation, tRNA processing and methylation.

  13. loss of HSD10 causes impaired mitochondrial precursor transcript processing which may explain mitochondrial dysfunction observed in HSD10 disease

  14. Defects in this gene are a cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. The encoded protein does not exhibit generalized alcohol dehydrogenase activity as was previously thought.

  15. Significantly higher levels of SRD5A1, AKR1C2, AKR1C3, and HSD17B10 mRNA were however found in bone metastases than in non-malignant and/or malignant prostate tissue

  16. Inhibition of mitochondrial RNase P by beta-amyloid is an unspecific effect and is not mediated by beta-amyloid interaction with SDR5C1.

  17. Two major HSD17B10 transcription start sites were identified by primer extension at -37 and -6 as well as a minor start site at -12 nucleotides from the initiation codon ATG.

  18. A 5-methylcytosine is present in both active and inactive X chromosomes at + 2259 nucleotide from the initiation ATG of the HSD17B10 gene, explaining the prevalence of the p.R130C mutation among HSD10 deficiency patients.

  19. analysis of clinical consequences of mutations in the HSD17B10 gene

  20. The role of ABAD in amyloid beta toxicity, was investigated.

Mouse (Murine) Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) interaction partners

  1. Data show that donor engraftment is necessary for BMT-mediated reduction in age-related amyloid plaque formation in prostaglandin E2 receptor subtype 2-null mice, and that this is accompanied by reduced neurotoxic forms of amyloid peptides.

  2. that 17beta-HSD-10 is a major product of both fetal and adult-type Leydig cells.

  3. ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction.Amyloid-beta peptide (Abeta) binding alcohol dehydrogenase (ABAD), an enzyme present in neuronal mitochondria, is a cofactor facilitating Abeta-induced cell stress.

HSD17B10 Antigen Profile

Antigen Summary

This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

Gene names and symbols associated with HSD17B10

  • hydroxysteroid (17-beta) dehydrogenase 10 (HSD17B10) antibody
  • hydroxysteroid (17-beta) dehydrogenase 10 (hsd17b10) antibody
  • hydroxysteroid 17-beta dehydrogenase 10 (HSD17B10) antibody
  • hydroxysteroid (17-beta) dehydrogenase 10 L homeolog (hsd17b10.L) antibody
  • hydroxysteroid (17-beta) dehydrogenase 10 (Hsd17b10) antibody
  • 17b-HSD10 antibody
  • 17bHSD10 antibody
  • ABAD antibody
  • Ads9 antibody
  • CAMR antibody
  • DUPXp11.22 antibody
  • ERAB antibody
  • Hadh2 antibody
  • HCD2 antibody
  • hsd10 antibody
  • HSD17B10 antibody
  • im:6899159 antibody
  • MHBD antibody
  • MRPP2 antibody
  • MRX17 antibody
  • MRX31 antibody
  • MRXS10 antibody
  • SCHAD antibody
  • SDR5C1 antibody
  • wu:fj61f03 antibody
  • zgc:101605 antibody

Protein level used designations for HSD17B10

hydroxysteroid (17-beta) dehydrogenase 10 , 3-hydroxyacyl-CoA dehydrogenase type-2 , hydroxyacyl-Coenzyme A dehydrogenase, type II , 3-hydroxy-2-methylbutyryl-CoA dehydrogenase , AB-binding alcohol dehydrogenase , amyloid-beta peptide binding alcohol dehydrogenase , endoplasmic reticulum-associated amyloid beta-peptide-binding protein , mitochondrial RNase P subunit 2 , mitochondrial ribonuclease P protein 2 , short chain L-3-hydroxyacyl-CoA dehydrogenase type 2 , short chain dehydrogenase/reductase family 5C, member 1 , short chain type dehydrogenase/reductase XH98G2 , 17-beta-HSD 10 , 17-beta-hydroxysteroid dehydrogenase 10 , 3-hydroxyacyl-CoA dehydrogenase type II , hydroxyacyl-Coenzyme A dehydrogenase type II , mitochondrial RNase P protein 2 , type II HADH , amyloid beta-peptide binding protein , short chain L-3-hydroxyacyl-CoA dehydrogenase , hydroxyacyl-Coenzyme A dehydrogenase, type II hydroxyacyl-Coenzyme A

GENE ID SPECIES
425758 Gallus gallus
450078 Danio rerio
549265 Xenopus (Silurana) tropicalis
465649 Pan troglodytes
480930 Canis lupus familiaris
100342235 Oryctolagus cuniculus
3028 Homo sapiens
446903 Xenopus laevis
15108 Mus musculus
63864 Rattus norvegicus
281809 Bos taurus
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