More product categories related to HSD17B10 ELISA Kit
More ELISA Kits for HSD17B10 Interaction Partners
Human Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) interaction partners
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This study proposes low-resolution models of the MRPP1-MRPP2 and MRPP1-MRPP2-MRPP3 complexes that suggest the overall architecture, stoichiometry, and orientation of subunits and tRNA substrates.
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17beta-Hydroxysteroid dehydrogenase type 10 is a multifunctional, homotetrameric, mitochondrial protein encoded by the HSD17B10 gene at Xp 11.2. This protein, 17beta-HSD10, is overexpressed in brain cells of Alzheimer's disease (AD) patients. Analysis of the impact of 17beta-HSD10 and its inhibitor, amyloid-beta peptide (Abeta), on the metabolism of neuroactive steroids offers a new approach to AD pathogenesis.
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Authors report two patients with novel missense mutations in the HSD17B10 gene (c.34G>C and c.526G>A), resulting in the p.V12L and p.V176M substitutions. Val12 and Val176 are highly conserved residues located at different regions of the MRPP2 structure.
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in addition to being an essential component of the RNase P reaction, MRPP1/2 serves as a processing platform for several down-stream tRNA maturation steps in human mitochondria.
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The S-nitrosation of a cysteine residue distal to the 3-hydroxyacyl-CoA dehydrogenase type 2 (HADH2) active site impaired catalytic activity.
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A computational study and enzyme inhibition assay with full length human 17-beta-HSD10 identifies risperidone as enzyme inhibitor and possible antineoplastic agent.
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Data suggest that HSD10 plays a role in alterations of energy metabolism by regulating mtDNA content in colorectal carcinomas.
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upon exposure to E2, ERalpha rapidly localizes to mitochondria, in which it interacts with HSD17B10 to modulate the expression of mitochondrial RNA transcripts.
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Our findings demonstrate that overexpression of HSD10 accelerates pheochromocytoma cell growth, enhances cell respiration, and increases cellular resistance to cell death induction.
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Three HSD10 variants associated with neurodegenerative disorders are inactive with cardiolipin
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The authors demonstrate elevated amounts of unprocessed pre-tRNAs and mRNA transcripts encoding mitochondrial subunits indicating deficient RNase P activity in HSD10 disease.
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The study showed that pathogenic mutations impair SDR5C1-dependent dehydrogenation, tRNA processing and methylation.
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loss of HSD10 causes impaired mitochondrial precursor transcript processing which may explain mitochondrial dysfunction observed in HSD10 disease
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Defects in this gene are a cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. The encoded protein does not exhibit generalized alcohol dehydrogenase activity as was previously thought.
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Significantly higher levels of SRD5A1, AKR1C2, AKR1C3, and HSD17B10 mRNA were however found in bone metastases than in non-malignant and/or malignant prostate tissue
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Inhibition of mitochondrial RNase P by beta-amyloid is an unspecific effect and is not mediated by beta-amyloid interaction with SDR5C1.
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Two major HSD17B10 transcription start sites were identified by primer extension at -37 and -6 as well as a minor start site at -12 nucleotides from the initiation codon ATG.
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A 5-methylcytosine is present in both active and inactive X chromosomes at + 2259 nucleotide from the initiation ATG of the HSD17B10 gene, explaining the prevalence of the p.R130C mutation among HSD10 deficiency patients.
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analysis of clinical consequences of mutations in the HSD17B10 gene
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The role of ABAD in amyloid beta toxicity, was investigated.
Mouse (Murine) Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) interaction partners
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Data show that donor engraftment is necessary for BMT-mediated reduction in age-related amyloid plaque formation in prostaglandin E2 receptor subtype 2-null mice, and that this is accompanied by reduced neurotoxic forms of amyloid peptides.
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that 17beta-HSD-10 is a major product of both fetal and adult-type Leydig cells.
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ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction.Amyloid-beta peptide (Abeta) binding alcohol dehydrogenase (ABAD), an enzyme present in neuronal mitochondria, is a cofactor facilitating Abeta-induced cell stress.
HSD17B10 Antigen Profile
Antigen Summary
This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
Gene names and symbols associated with HSD17B10
- hydroxysteroid (17-beta) dehydrogenase 10 (HSD17B10) antibody
- hydroxysteroid (17-beta) dehydrogenase 10 (hsd17b10) antibody
- hydroxysteroid 17-beta dehydrogenase 10 (HSD17B10) antibody
- hydroxysteroid (17-beta) dehydrogenase 10 L homeolog (hsd17b10.L) antibody
- hydroxysteroid (17-beta) dehydrogenase 10 (Hsd17b10) antibody
- 17b-HSD10 antibody
- 17bHSD10 antibody
- ABAD antibody
- Ads9 antibody
- CAMR antibody
- DUPXp11.22 antibody
- ERAB antibody
- Hadh2 antibody
- HCD2 antibody
- hsd10 antibody
- HSD17B10 antibody
- im:6899159 antibody
- MHBD antibody
- MRPP2 antibody
- MRX17 antibody
- MRX31 antibody
- MRXS10 antibody
- SCHAD antibody
- SDR5C1 antibody
- wu:fj61f03 antibody
- zgc:101605 antibody
Protein level used designations for HSD17B10
hydroxysteroid (17-beta) dehydrogenase 10 , 3-hydroxyacyl-CoA dehydrogenase type-2 , hydroxyacyl-Coenzyme A dehydrogenase, type II , 3-hydroxy-2-methylbutyryl-CoA dehydrogenase , AB-binding alcohol dehydrogenase , amyloid-beta peptide binding alcohol dehydrogenase , endoplasmic reticulum-associated amyloid beta-peptide-binding protein , mitochondrial RNase P subunit 2 , mitochondrial ribonuclease P protein 2 , short chain L-3-hydroxyacyl-CoA dehydrogenase type 2 , short chain dehydrogenase/reductase family 5C, member 1 , short chain type dehydrogenase/reductase XH98G2 , 17-beta-HSD 10 , 17-beta-hydroxysteroid dehydrogenase 10 , 3-hydroxyacyl-CoA dehydrogenase type II , hydroxyacyl-Coenzyme A dehydrogenase type II , mitochondrial RNase P protein 2 , type II HADH , amyloid beta-peptide binding protein , short chain L-3-hydroxyacyl-CoA dehydrogenase , hydroxyacyl-Coenzyme A dehydrogenase, type II hydroxyacyl-Coenzyme A
GENE ID | SPECIES |
---|---|
425758 | Gallus gallus |
450078 | Danio rerio |
549265 | Xenopus (Silurana) tropicalis |
465649 | Pan troglodytes |
480930 | Canis lupus familiaris |
100342235 | Oryctolagus cuniculus |
3028 | Homo sapiens |
446903 | Xenopus laevis |
15108 | Mus musculus |
63864 | Rattus norvegicus |
281809 | Bos taurus |
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