anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) Antibodies

HCN4 encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. Additionally we are shipping HCN4 Kits (14) and HCN4 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HCN4 10021 Q9Y3Q4
HCN4 59266 Q9JKA7
HCN4 330953  
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Top anti-HCN4 Antibodies at antibodies-online.com

Showing 10 out of 91 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mammalian Mouse Un-conjugated ISt, IHC, WB   5 mL Log in to see 2 to 6 Days
$366.67
Details
Human Mouse HRP AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$422.40
Details
Human Mouse FITC AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$426.80
Details
Human Mouse Alkaline Phosphatase (AP) AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$429.00
Details
Human Mouse Biotin AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$431.20
Details
Human Mouse PE AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$432.30
Details
Human Mouse Streptavidin AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$433.40
Details
Human Mouse APC AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$434.50
Details
Human Mouse PerCP AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$434.50
Details
Human Mouse Atto 488 AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$435.60
Details

HCN4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-HCN4 Antibodies

  1. Mammalian Monoclonal HCN4 Primary Antibody for ISt, IHC - ABIN1304701 : Stradleigh, Ishida: Fixation strategies for retinal immunohistochemistry. in Progress in retinal and eye research 2015 (PubMed)
    Show all 19 Pubmed References

  2. Human Polyclonal HCN4 Primary Antibody for IF (p), IHC (p) - ABIN733043 : Li, Hong, Zhang, Zhou, Ji, Li, Hu, Li, Sun, Zhang, Xin, Yusufuaji, Xiong, Tang: Association between reversal in the expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel and age-related atrial fibrillation. in Medical science monitor : international medical journal of experimental and clinical research 2014 (PubMed)

More Antibodies against HCN4 Interaction Partners

Human Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) interaction partners

  1. We here report on multiple families harboring HCN4 mutations, who show significant dilation of the aorta ascendens

  2. A novel splice site HCN4 gene mutation was identified in a large family with familial bradycardia.

  3. Sick sinus syndrome (SSS) with HCN4 mutations may form a distinct SSS subgroup characterized by early clinical manifestation after adolescence and frequent association with atrial fibrillation and left ventricular noncompaction.

  4. This study has identified 4 synonymous variants in the HCN4 gene and 3 SNPs in the CYP3A4 (show CYP3A4 Antibodies) gene. None of the variants appear to have a major effect on the reduction of HR produced by ivabradine.

  5. HCN4 channel remodeling following exercise and subsequent sinus bradycardia in athletes is controlled by miR (show MLXIP Antibodies)-423-5p.

  6. Our results indicate that HCN4 channel function is modulated by cav-3 (show CAV3 Antibodies). LQTS-associated mutations of cav-3 (show CAV3 Antibodies) differentially influence pacemaker current properties indicating a pathophysiological role in clinical manifestations.

  7. Identified in Brugada syndrome patient HCN4 mutation results in reduced channel function in HEK293 cells.

  8. S672R mutation results in a constitutive shift of the dynamic auto-inhibitory equilibrium toward inactive states of HCN4 and broadens the free-energy well of the apo (show C9orf3 Antibodies)-form, enhancing the millisecond to microsecond dynamics of the holo-form at sites critical for gating cAMP binding.

  9. Our results confirm the genetic evidence for the involvement of the HCN4 mutations in the combined bradycardia-non compaction cardiomyopathy phenotype and illustrates that.

  10. Aged patients with sinus rhythm exhibited significantly higher expression levels of HCN2 and HCN4 channel mRNA and protein (P<0.05), but significantly lower expression levels of miR1 and 133, compared with those of adult patients with sinus rhythm.

Rabbit Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) interaction partners

  1. HCN4-overexpressing mouse embryonic stem cell -derived cardiomyocytes produce rapid ectopic ventricular rhythms as a biological pacemaker.

  2. Ischemia-reperfusion is harmful to the sinoatrial node and reduces the expression of HCN4.

  3. SAP97 contributes to isoform specific organization of HCN channels within specific domains in the sinoatrial node of the rabbit.

  4. HCN protein expression in the rabbit pacemaker region, was investigated.

Mouse (Murine) Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) interaction partners

  1. This study demonstrated that HCN4 (show HCN3 Antibodies) regulate the glutamate (show GRIN1 Antibodies) release from presynaptic terminals that target excitatory, but not inhibitory spinal substantia gelatinosa interneurons.

  2. Data show that prostaglandin E2 receptor EP3 subtype (EP3 (show PTGER3 Antibodies)) was expressed in the interstitial cells of Cajal (ICCs) of the bladder and activated hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

  3. that hyperpolarization-activated cyclic nucleotide-gated cation channel 4 (HCN4) expression was significantly higher and HCN2 (show HCN2 Antibodies) expression was significantly lower in fetal day 13 mice than in adults

  4. beating rate of hiPSC-CMs (show Cd2ap Antibodies) co-cultured with aggregates of HCN4 (show HCN3 Antibodies)-overexpressing mESC-CMs (show Cd2ap Antibodies) was significantly higher than that of non-treated hiPSC-CMs (show Cd2ap Antibodies) and that of hiPSC-CMs (show Cd2ap Antibodies) co-cultured with aggregates of non-overexpressing mESC-CMs (show Cd2ap Antibodies)

  5. study establishes the role of f-channels in cardiac automaticity and indicates that arrhythmia related to HCN loss-of-function may be managed by pharmacological or genetic inhibition of GIRK4 (show KCNJ5 Antibodies) channels

  6. HCN1 (show HCN1 Antibodies), HCN2 (show HCN2 Antibodies), and HCN4 (show HCN3 Antibodies) subunits may have distinct physiological roles in the developing hippocampus.

  7. Shox2 (show SHOX2 Antibodies) regulates dorsal mesenchymal protrusion fate and development by controlling BMP signaling through the Smad (show SMAD1 Antibodies)-dependent pathway to drive tissue growth and to induce Hcn4 (show HCN3 Antibodies) expression

  8. HCN4 (show HCN3 Antibodies) dynamically marks the first heart field and conduction system precursors.

  9. testosterone induced cardiomyogenesis, at least in part, by recruiting the AR receptor to the regulatory regions of the MEF2C (show MEF2C Antibodies) and HCN4 (show HCN3 Antibodies) genes.

  10. Data suggest that TRPM7 (show TRPM7 Antibodies) influences diastolic membrane depolarization and automaticity in embryonic myocardium and sinoatrial node (SAN) indirectly via regulation of Hcn4 (show HCN3 Antibodies) expression.

HCN4 Antigen Profile

Protein Summary

This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15.

Gene names and symbols associated with HCN4

  • hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4) antibody
  • hyperpolarization activated cyclic nucleotide gated potassium channel 4 (hcn4) antibody
  • hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (Hcn4) antibody
  • hyperpolarization-activated, cyclic nucleotide-gated K+ 4 (Hcn4) antibody
  • Bcng3 antibody
  • HAC4 antibody
  • Hcn3 antibody
  • SSS2 antibody

Protein level used designations for HCN4

hyperpolarization activated cyclic nucleotide-gated potassium channel 4 , hyperpolarization activated cyclic nucleotide-gated cation channel 4 , potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 , hyperpolarization-activated, cyclic nucleotide-gated K+ 4 , HAC-4 , hyperpolarization activated cation channel , hyperpolarization-activated cation channel 4 , BCNG-3 , brain cyclic nucleotide-gated channel 3 , hyperpolarization-activated, cyclic nucleotide-gated K+ 3

GENE ID SPECIES
100544822 Meleagris gallopavo
100560546 Anolis carolinensis
10021 Homo sapiens
59266 Rattus norvegicus
785689 Bos taurus
100009452 Oryctolagus cuniculus
330953 Mus musculus
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