ISG15 Ubiquitin-Like Modifier (ISG15) ELISA Kits

The protein encoded by ISG15 is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Additionally we are shipping ISG15 Antibodies (141) and ISG15 Proteins (20) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ISG15 9636 P05161
ISG15 100038882 Q64339
Anti-Rat ISG15 ISG15 298693  
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Top ISG15 ELISA Kits at

Showing 8 out of 19 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.195 ng/mL 0.78-50 ng/mL Typical standard curve 96 Tests 13 to 16 Days
Mouse 0.078 ng/mL 0.312-20 ng/mL Typical standard curve 96 Tests 15 to 18 Days
Cow 0.078 ng/mL 0.312-20 ng/mL Typical standard curve 96 Tests 15 to 18 Days
Chicken 0.938 pg/mL 1.563-100 pg/mL   96 Tests 12 to 14 Days
Monkey 18.75 pg/mL 31.25-2000 pg/mL   96 Tests 12 to 14 Days
Pig 18.75 pg/mL 31.25-2000 pg/mL   96 Tests 12 to 14 Days
Rabbit 0.75 pg/mL 1.25-80 pg/mL   96 Tests 12 to 14 Days
Human 11.51 pg/mL 312.5 pg/mL - 20000 pg/mL   96 Tests 8 to 12 Days

Top referenced ISG15 ELISA Kits

  1. Human ISG15 ELISA Kit for Sandwich ELISA - ABIN367597 : Zaheer, Wiehler, Hudy, Traves, Pelikan, Leigh, Proud: Human rhinovirus-induced ISG15 selectively modulates epithelial antiviral immunity. in Mucosal immunology 2014 (PubMed)

More ELISA Kits for ISG15 Interaction Partners

Human ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. The current study revealed that BAG3 did not interact with ISG15, but positively regulated ISG15 expression in pancreatic ductal adenocarcinoma cancer.

  2. Non-muscle myosin IIA is post-translationally modified by interferon-stimulated gene 15 in breast cancer cells

  3. ISG15 expression is relatively high in SLE patients and correlates with disease activity before treatment. ISG15 expression is higher in SLE patients with lymphocytopenia before treatment.

  4. the present study demonstrates that covalent ISG15 conjugation produces a novel CHIP regulatory mode that enhances the tumor-suppressive activity of CHIP.

  5. Protein ISG15 mediates the tumorigenesis via c-MET/Fyn/beta-catenin pathway in Esophageal squamous cell carcinoma cell lines.

  6. The structures of ubiquitin-specific protease 18 (USP18) and a USP18-Interferon-stimulated 15-KDa protein (ISG15) complex indicate the molecular basis of the specificity of the protease and its interaction with the type I interferon receptor [Review].

  7. These results demonstrate that virus-induced IFN-lambda4 potently blocks IFN-alpha signalling by inducing high protein levels of ISG15 and USP18. Moreover, the data clearly demonstrate that DAA therapy restores IFN-alpha responsiveness in HCV-infected cells.

  8. IFN-gamma increases free ISG15 levels in the cytoplasm and ISGylation in the nucleus and cytoplasm, but in a manner distinct between MCF-7 and MDA-MB-231cells.

  9. Hepatitis E virus may promote production of IFN-alpha/beta and expression of ISG15 via ORF3 in the early stages, and increased ISG15 subsequently inhibited the production of IFN-alpha/beta.

  10. ISG15 reduces miR-17-5p levels and thereby promotes Beclin-1-mediated autophagy

  11. ISGylation is a ubiquitin-like modification that controls exosome release. ISGylation induction decreases microvesicular body numbers and impairs exosome secretion. Specifically, ISGylation of the MVB protein TSG101 induces its aggregation and degradation, being sufficient to impair exosome secretion.

  12. The species-specific gain-of-function in antiviral immunity observed in ISG15 deficiency is explained by the requirement of ISG15 to sustain USP18 levels in humans.

  13. HIV-1 IIIB infection of myeloid ThP-1 cells also reduced the IFN-alpha-mediated induction of the anti-viral gene, ISG15, but not MxA, revealing a functional consequence of this HIV-1-mediated immune evasion strategy.

  14. DNA damage induces ISG15 conjugation to p53 and this modification markedly enhances the binding of p53 to the promoters of its target genes as well as of its own gene by promoting phosphorylation and acetylation.

  15. Studied foot-and-mouth disease virus (FMDV) Lbpro targeting of ISG15. Show a previously undescribed mechanism by which viruses interfere with the ubiquitin and ubiquitin-like systems.

  16. ISG15 is able to trigger IFN-gamma production and other signaling pathways suggesting it is a potential cytokine that could interact with still unknown receptors. (Review)

  17. ISG15 induces cancer cell apoptosis by disrupting the NF-kappaB signaling pathway. This study highlighted a novel role of ISG15 in tumor suppression.

  18. The Interferon-stimulated 15-KDa protein (ISG15) rs1921 variant and ISG15 expression are associated with HBV-related liver diseases.

  19. findings revealed that MERS-CoV PLpro chiefly engages human ISG15 through its C-terminal domain; structure of MERS-CoV PLpro was solved to 2.4 A in complex with the C-terminal domain of hISG15; structure of MERS-CoV PLpro in complex with this domain exposed the interface between these two entities

  20. Our study demonstrates a protumor role of ISG15, and suggests that ISG15 is a prognostic predictor and a potential therapeutic target for nasopharyngeal carcinoma

Cow (Bovine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. Data suggest that ISG15 is involved in early blastocyst/embryo development; ISG15 appears to regulate gene expression in developing blastocyst; specifically, ISG15 is required for up-regulation of IFNT expression in blastocyst development. (ISG15 = ubiquitin-like protein ISG15, interferon-stimulated gene 15 protein; IFNT = interferon-tau)

  2. ISG 15 gene expression is upregulated during 16-18 days of pregnancy and could be used as an early pregnancy marker in dairy cows, especially in heifers.

  3. ISG15, UBE1l and UBCH8 genes are significantly upregulated in the artificially inseminated pregnant cows.

  4. Data indicate that the expression profiles of ISG15, MX1, MX2, and OAS1 could be a useful diagnostic biomarker of gestation.

  5. Bovine herpesvirus 1 protein bICP0 represses the transcription of bISG15 in fetal bovine lung cells.

  6. ISG15 is an antiviral and inducible protein in bovine immunodeficiency virus infected bovin lung cells.

  7. ISG15 and conjugated proteins were expressed in corpus luteum of both cyclic and pregnant cows regardless of pregnancy status and were upregulated during early pregnancy

  8. interferon-stimulated protein(ISG15) was localized throughout the endometrium on day 18-23 of bovine pregnancy and was specifically localized to organelles and compartments of endometrial epithelial cells and stromal cells

  9. rbovISG15 is unstable over time in storage & dialysis. In vivo, conjugation of ISG15 to targeted proteins occurs inside the cell.

Zebrafish ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. Overall, these data demonstrate the antiviral effect of a fish ISG15 protein, revealing the conservation among vertebrates of an ISGylation mechanism likely directed against viruses.

Pig (Porcine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. As an innate immune response protein with broad-spectrum antiviral activity, the up-regulation of ISG15 mediated by IRF1 in porcine cells is reported for the first time. These results warrant further investigation into the antiviral activity of porcine IRF1 against reported swine viruses

  2. NSP2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of ISG15.

  3. Results report identification and cloning of the ISG15 and ISG43 genes in pig.

Mouse (Murine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. this study shows that cysteine-reactive free ISG15 generates IL-1beta-producing CD8alpha(+) dendritic cells at the site of infection

  2. ISGylation is a ubiquitin-like modification that controls exosome release. ISGylation induction decreases microvesicular body numbers and impairs exosome secretion. Specifically, ISGylation of the MVB protein TSG101 induces its aggregation and degradation, being sufficient to impair exosome secretion.

  3. Murine Isg15 does not control Usp18 accumulation and IFN-alpha/beta signaling.

  4. Extracellular ISG15 signals cytokine secretion through the LFA-1 integrin receptor (CD11a/CD18) in natural killer cells.

  5. results demonstrate that ISG15 governs the dynamic functionality of mitochondria, specifically, OXPHOS and mitophagy, broadening its physiological role as an antiviral agent.

  6. Loss of ISG15 expression and type I IFN signaling have transient effects on bacterial burden during M. tuberculosis infection in mice

  7. ISG15 acts as an immunomodulator in the cornea and plays a critical role in controlling fungal keratitis.

  8. USP18's ISG15 specificity is mediated by a small interaction interface.

  9. Posttranslational protein modification by ISG15 plays an important role in antiviral defense

  10. These studies provide evidence, ISG15 is elevated following TBI in mice, preceding MLCK elevation, development of BBB disruption, and cerebral edema.

  11. Kruppel-like factor 9 (KLF9) is a haploinsufficient tumor suppressor in the ApcMin/+ mouse colon by suppressing expression of ISG15, an apoptosis-inhibiting cytokine.

  12. Propose that Isg15-dependent degradation of p53 represents an alternative mechanism of controlling p53 protein levels, and, thus, it is an attractive pathway for drug discovery.

  13. Embryo mortality occurs in pregnant Isg15(-/-) mice, is exacerbated by environmental insults like maternal hypoxia, and might result from impaired early decidualization, vascular development, and formation of the labyrinth.

  14. Enhanced resistance upon influenza B infection in USP18(C61A/C61A) mice was completely reversed in USP18(C61A/C61A) mice, which additionally lack ISG15, providing evidence that the observed reduction in viral titers is ISG15 dependent

  15. Authors found that ISG15 protects mice from influenza A virus and Sendai virus induced lethality by a conjugation-dependent mechanism in both of these models.

  16. study demonstrated that ISG15 had an anti-apoptotic effect on the beta cell line MIN6; conclusion is consistent with previous reports that ISG15 has a protective role

  17. The ISG15 conjugation system represents a critical innate response mechanism in cardiomyocytes to fight the battle against invading pathogens, limiting inflammatory cardiomyopathy, heart failure, and death.

  18. ISG15 does not appear to play a key role in IFN-beta-mediated C2C12 myoblast cell fusion

  19. Interferon-stimulated gene 15 (ISG15) mitigates MNV-1 replication.

  20. Protein interferon-stimulated gene 15 conjugation delays but does not overcome coronavirus proliferation in a model of fulminant hepatitis.

Horse (Equine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. The expression of interferon-stimulated protein 15 kDa (ISG15) during pregnancy is described.[ISG15]

ISG15 Antigen Profile

Antigen Summary

The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted.

Gene names and symbols associated with ISG15

  • ISG15 ubiquitin-like modifier (ISG15) antibody
  • ISG15 ubiquitin-like modifier (isg15) antibody
  • ISG15 ubiquitin-like modifier (Isg15) antibody
  • G1p2 antibody
  • hUCRP antibody
  • IFI15 antibody
  • IGI15 antibody
  • IP17 antibody
  • Irfp antibody
  • ISG15 antibody
  • ISG17 antibody
  • ISG17/UCRP antibody
  • si:rp71-1c23.2 antibody
  • UCRP antibody

Protein level used designations for ISG15

interferon, alpha-inducible protein (clone IFI-15K) , interferon-induced 17-kDa/15-kDa protein , interferon-stimulated protein, 15 kDa , ubiquitin cross-reactive protein , ubiquitin-like protein ISG15 , boUCRP , interferon-stimulated gene product 17 , ISG15 ubiquitin-like modifier , si:rp71-1c23.2 , zfISG15 , interferon stimulated gene, 15 kDa , interferon, alpha-inducible protein , interferon-induced 17 kDa protein , interferon-stimulated protein 15 , interferon-induced 15 kDa protein , interferon-induced 15-KDa protein , interferon-stimulated protein (15 kDa) , interferon stimulated gene 17 , interferon-stimulated protein 17/ubiquitin cross-reactive protein

9636 Homo sapiens
281871 Bos taurus
465390 Pan troglodytes
558956 Danio rerio
700141 Macaca mulatta
100145895 Sus scrofa
100174787 Felis catus
100038882 Mus musculus
298693 Rattus norvegicus
100855667 Canis lupus familiaris
100354504 Oryctolagus cuniculus
443057 Ovis aries
102169982 Capra hircus
100066364 Equus caballus
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