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LIM homeobox transcription factor; involved in topographic organization of motor neurons.
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Cow (Bovine) Polyclonal ISL2 Primary Antibody for WB - ABIN2780062
Svärd, Heby-Henricson, Henricson, Persson-Lek, Rozell, Lauth, Bergström, Ericson, Toftgård, Teglund: Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. in Developmental cell 2006
lack both Isl1 (show ISL1 Antibodies) and Isl2, large numbers of motor neurons exited the neural tube, even prior to the appearance of boundary cap cells at the ventral exit points
X-ray crystal- and small-angle x-ray scattering-derived solution structures of an Lhx4 (show LHX4 Antibodies).Isl2 complex exhibit many similarities with that of Lhx3 (show LHX3 Antibodies).Isl1 (show ISL1 Antibodies); structural differences supported by mutagenic studies reveal differences in the mechanisms of binding.
Isl2 specifies RGC laterality by repressing an ipsilateral pathfinding program unique to VTC RGCs and involving Zic2 (show ZIC2 Antibodies) and EphB1 (show EPHB1 Antibodies). This genetic hierarchy controls binocular vision
The second wave of expression at E12.5 includes Lhx3 (show LHX3 Antibodies), 5, 9, Isl2, and Lmx1b (show LMX1B Antibodies) in the differentiating sensory epithelia with cellular specificities.
Successful purification and crystallization of an engineered complex comprising the LIM (show PDLIM5 Antibodies) domains of motor neuron protein Lhx4 (show LHX4 Antibodies) and the Lim (show PDLIM5 Antibodies) binding domain of Isl2 (islet 2 protein) are reported.
Data describe how the dosage of LIM homeodomain (show LHX2 Antibodies) proteins Isl1 (show ISL1 Antibodies) and Isl2 and LIM (show PDLIM5 Antibodies)-only protein Lmo4 (show LMO4 Antibodies) influences the assembly and function of complexes involved in the generation of spinal motor neurons (MNs (show GYPE Antibodies)) and V2a interneurons (INs (show INS Antibodies)).
Experiments in Isl2/EphA3 (show EPHA3 Antibodies) knock-in mice test the interactions between effects of molecular labels and correlated activity during the development of neural connectivity.
The broad expression of Isl-2 gene in tissues during embryogenesis and adult development suggests that it may be involved in both differentiation and maintenance of these tissues and might play an important role.
Isl2a is expressed in the lateral posterior mesoderm prior to angioblast migration. Isl2a-deficient angioblasts show disorganized migration to the midline to form axial vessels. Its expression is negatively regulated by Notch (show NOTCH1 Antibodies) activity. It positively regulates flt4 (show FLT4 Antibodies), a VEGF-C (show VEGFC Antibodies) receptor repressed by Notch (show NOTCH1 Antibodies) during angiogenesis. Isl2a may be an intermediate between Notch (show NOTCH1 Antibodies) signaling and genetic programs controlling angioblasts.
Prdm14 (show PRDM14 Antibodies) regulates caudal (show CAD Antibodies) rimary axon outgrowth through activation of islet2 expression.
primary motoneuron subtypes are likely to be specified by factors that act in parallel to or upstream of islet1 (show ISL1 Antibodies) and islet2
LIM homeobox transcription factor; involved in topographic organization of motor neurons
insulin gene enhancer protein ISL-2
, islet 2
, domesticus (clone 1.6 kB) islet-2
, ISL2 transcription factor, LIM/homeodomain, (islet-2)
, insulin related protein 2 (islet 2)
, insulin gene enhancer protein isl-2
, insulin gene enhancer protein isl-2a