Immunoglobulin Superfamily, Member 8 (IGSF8) ELISA Kits

IGSF8 encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Additionally we are shipping IGSF8 Antibodies (79) and IGSF8 Proteins (13) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
IGSF8 93185 Q969P0
IGSF8 140559 Q8R366
Anti-Rat IGSF8 IGSF8 304979  
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Top IGSF8 ELISA Kits at

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Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.039 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests 15 to 18 Days
  96 Tests 21 to 31 Days

More ELISA Kits for IGSF8 Interaction Partners

Human Immunoglobulin Superfamily, Member 8 (IGSF8) interaction partners

  1. EWI-2 negatively regulates TGF-beta signaling and its downstream events including cytostasis (in vitro and in vivo), EMT-like changes, cell migration, CD271-dependent invasion, and lung metastasis (in vivo).

  2. Authors demonstrated that EWI-2wint promotes CD81 clustering and confinement in CD81-enriched areas.

  3. The EWI-2/alpha-actinin complex is involved in regulation of the actin cytoskeleton at T cell immune and virological synapses, providing a link between membrane microdomains and the formation of polarized membrane structures involved in T cell recognition.

  4. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.

  5. analysis of interacting regions of CD81 and two of its partners, EWI-2 and EWI-2wint, and their effect on hepatitis C virus infection

  6. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells.

  7. EWI-2-dependent reorganization of alpha4beta1-CD81 complexes on the cell surface is responsible for EWI-2 effects on integrin-dependent morphology and motility functions

  8. EWI proteins EWI-2 and EWI-F, alpha3beta1 and alpha6beta4 integrins, and protein palmitoylation have contrasting effects on cell surface CD9 organization

  9. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins

  10. Important functions of recently activated dendritic cells are thus critically modulated by the newly discovered HSPA8-EWI-2 interaction.

  11. CD81 partner EWI-2wint inhibits hepatitis C virus entry [EWI-2wint]

  12. EWI-2 causes a substantial molecular reorganization of multiple molecules known to affect proliferation and/or invasion of astrocytes and/or glioblastomas.

Mouse (Murine) Immunoglobulin Superfamily, Member 8 (IGSF8) interaction partners

  1. IgSF8 is present in developing olfactory sensory neuron synapses, and it interacts with Tspan CD9.

  2. Igsf8-deficient eggs retain the normal level and localization of CD9, resulting in normal microvilli formation indicating that IGSF8 is dispensable in fertility.

  3. This study showed that the EWI2 cytoplasmic tail actively engages with the cell membrane via phosphatidylinositol phosphate binding and palmitoylation.

  4. Igsf8 is first expressed at E9.5 in a ventral domain of the neural tube, with dorsal expression apparent at E10.5.. From E11.5, Igsf8 occurs at the edge of the ventricular zone, in postmitotic neuroblasts, and in sensory ganglia.

  5. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins

  6. Report that the expression level of EWI-2 on the Cd9(-/-) oocyte surface is <10% of the wild-type level. Hence, the severe reduction in EWI-2 activity may be responsible for the loss of fusion ability.

  7. Immunoglobulin superfamily member IgSF8 (EWI-2) and CD9 in fertilisation: evidence of distinct functions for CD9 and a CD9-associated protein in mammalian sperm-egg interaction.

IGSF8 Antigen Profile

Antigen Summary

This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein.

Gene names and symbols associated with IGSF8

  • immunoglobulin superfamily, member 8 (igsf8) antibody
  • immunoglobulin superfamily member 8 (IGSF8) antibody
  • immunoglobulin superfamily, member 8 (Igsf8) antibody
  • AA033172 antibody
  • AU041109 antibody
  • CD81P3 antibody
  • CD316 antibody
  • ESTM34 antibody
  • EWI-2 antibody
  • EWI2 antibody
  • IGSF8 antibody
  • KCT-4 antibody
  • LIR-D1 antibody
  • MGC77222 antibody
  • MGC151661 antibody
  • PGRL antibody
  • R75384 antibody

Protein level used designations for IGSF8

immunoglobulin superfamily member 8 , immunoglobulin superfamily, member 8 , immunoglobulin superfamily member 8-like , CD81 partner 3 , glu-Trp-Ile EWI motif-containing protein 2 , keratinocytes-associated transmembrane protein 4 , prostaglandin regulatory-like protein , PG regulatory-like protein , keratinocyte-associated transmembrane protein 4

404631 Danio rerio
469549 Pan troglodytes
519266 Bos taurus
100058209 Equus caballus
100154024 Sus scrofa
100338663 Oryctolagus cuniculus
100441861 Pongo abelii
100595459 Nomascus leucogenys
93185 Homo sapiens
140559 Mus musculus
304979 Rattus norvegicus
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