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The protein encoded by ID1 is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. Additionally we are shipping ID1 Antibodies (70) and ID1 Proteins (8) and many more products for this protein.
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Human ID1 ELISA Kit for Sandwich ELISA - ABIN841619
Nguyen, Geens, Mertzanidou, Jacobs, Heirman, Breckpot, Spits: Gain of 20q11.21 in human embryonic stem cells improves cell survival by increased expression of Bcl-xL. in Molecular human reproduction 2014
Gain and loss of id1 function in vivo demonstrated that Id1 promotes stem cell quiescence. The increased id1 expression observed in neural stem cells in response to injury appeared independent of inflammatory signals.
We show that expression of Id-1 (show IDH1 ELISA Kits), a negative regulator of myogenesis, is enhanced in Dnmt1 (show DNMT1 ELISA Kits)-deficient cultures, leading to enhanced transdifferentiation of myoblasts toward the osteogenic lineage. Thus, these studies demonstrate that Dnmt1 (show DNMT1 ELISA Kits) influences cellular identity and determines lineage fidelity.
a loss of CULLIN3 represents a common signaling node for controlling the activity of intracellular WNT (show WNT2 ELISA Kits) and SHH (show SHH ELISA Kits) signaling pathways mediated by ID1
These results reveal a E2F1 (show E2F1 ELISA Kits)/miR-17-92/ENH1 (show PDLIM5 ELISA Kits)/Id1 regulatory axis during myogenesis.
Id1 enables both Lewis lung carcinoma cells and the host microenvironment for an effective liver colonization.
adipose tissue-specific overexpression of Id1 causes age-associated and high-fat diet-induced obesity in mice. Id1 suppresses BAT thermogenesis by binding to and suppressing PGC1alpha transcriptional activity. Lack of Id1 increases beige (show LYST ELISA Kits) gene and Ucp1 (show UCP1 ELISA Kits) expression in the WAT in response to cold exposure. Furthermore, brown-like differentiation is increased in Id1-deficient mouse embryonic fibroblasts.
If Gfi1 levels fall below a threshold, Id1 expression increases and renders E2A (show TCF3 ELISA Kits) unable to function, which prevents hematopoietic progenitors from engaging along the B lymphoid lineage
Id1 may promote cell cycle progression of endothelial progenitor cells (EPCs), and that Wnt2 (show WNT2 ELISA Kits) may be important in Id1 regulation of the cell cycle of EPCs.
Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin
Collectively, our results suggest that ENH1 plays an important role in the activation of myogenesis through the repression of Id2 activity.
Data indicate that upregulation of E2-2 (show TCF4 ELISA Kits) protein markedly attenuated the inhibitor of DNA-binding 1 (ID1)-mediated increase in endothelial progenitor cells (EPCs) proliferation and migration.
Low ID1 expression is associated with breast cancer.
ID1, CTCF (show CTCF ELISA Kits) and ELK1 (show ELK1 ELISA Kits) may be associated with prostate cancer, and may be potential therapeutic targets for the treatment of this disease.
CaMKII (show CAMK2G ELISA Kits) can directly phosphorylate Beclin 1 (show BECN1 ELISA Kits) at Ser90 to promote K63-linked ubiquitination of Beclin 1 (show BECN1 ELISA Kits) and activation of autophagy; it also promotes K63-linked ubiquitination of inhibitor of differentiation 1/2 (Id-1/2) by catalyzing phosphorylation of Id proteins and recruiting TRAF-6 (show TRAF6 ELISA Kits)
ID1 expression was associated with the proliferation, invasion and migration of SACC cells. The observed inhibition of SACC cell growth, invasion and migration following knockdown of ID1 expression in the present study, may have been due to restoration of the balance between oncogenic and tumor-suppressive effects resulting from changes in the expression of downstream genes or associated proteins.
The mutual correlation between the expression level of TWIST1 (show TWIST1 ELISA Kits) and ID1 might be a critical factor driving the process of the human odontoblasts' differentiation.
Id1 enables lung cancer liver colonization by activating an epithelial mesenchymal transformation program in tumor cells and establishing the pre-metastatic niche.
High ID1 expression is associated with breast cancer.
ID1 expression impacts the sensitivity of colon cancer cells to 5-FU and may be considered as a potential predictive marker in colorectal carcinoma treatment.
Reducing ID1 gene expression reduces metastatic spread of salivary gland neoplasms.
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene.
inhibitor of DNA binding 1
, DNA-binding protein inhibitor id-1
, inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
, DNA-binding protein inhibitor ID-1
, inhibitor of DNA binding 6
, Inhibitor of DNA binding 1 helix-loop-helix protein (splice varaiation)
, Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation)
, class B basic helix-loop-helix protein 24
, dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein)
, inhibitor of differentiation 1
, helix-loop-helix protein