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ING4 encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling.
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Human Polyclonal ING4 Primary Antibody for WB - ABIN1944775
Shiseki, Nagashima, Pedeux, Kitahama-Shiseki, Miura, Okamura, Onogi, Higashimoto, Appella, Yokota, Harris: p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. in Cancer research 2003
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Human Polyclonal ING4 Primary Antibody for ELISA, WB - ABIN105223
Unoki, Shen, Zheng, Harris: Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility. in The Journal of biological chemistry 2006
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Inhibitor of growth (show ING1 Antibodies) 4 upregulation plus radiotherapy induced synergistic tumor suppression in SPC (show UCN3 Antibodies)-A1 xenografts implanted in athymic nude mice. Thus, the restoration of inhibitor of growth (show ING1 Antibodies) 4 function might provide a potential strategy for non-small cell lung cancer radiosensitization.
Results found that ING4 expression was significantly reduced in CRC (show CALR Antibodies) tissues and associated with increased lymph node metastasis, advanced TNM (show ODZ1 Antibodies) stage and poor overall survival. Also, ING4 suppressed CRC (show CALR Antibodies) angiogenesis by inhibition of Sp1 (show PSG1 Antibodies) expression and transcriptional activity through destabilization and ubiquitin degradation and down-regulation of Sp1 (show PSG1 Antibodies) downstream pro-angiogenic factors MMP-2 (show MMP2 Antibodies) and COX-2 (show COX2 Antibodies).
Low ING4 expression is associated with malignant phenotype and temozolomide chemoresistance in glioblastomas.
ING4 directly binds the Miz1 (show ZBTB17 Antibodies) promoter and is required to induce Miz1 (show ZBTB17 Antibodies) mRNA and protein expression during luminal cell differentiation.
The oncogenic role of miR (show MLXIP Antibodies)-330 in Hepatocellular Carcinoma Cells is linked to downregulation of ING4.
ING4 binds double-stranded DNA through its central region with micromolar affinity.
results indicate that the combination of ING4 and PTEN may provide an effective therapeutic strategy for HCC (show FAM126A Antibodies)
ING4 can facilitate cancer cell sensitivity to chemotherapy and radiotherapy. Although ING4 loss is observed for many types of cancers, increasing evidences show that ING4 can be used for gene therapy. In this review, the recent progress of ING4 regulating tumorigenesis is discussed
ING4 inhibits CRC (show CALR Antibodies) invasion and metastasis probably via a switch from mesenchymal marker N-cadherin (show CDH2 Antibodies) to epithelial marker E-cadherin (show CDH1 Antibodies) through downregulation of Snail1 (show SNAI1 Antibodies) epithelial-mesenchymal transition (EMT (show ITK Antibodies))-inducing transcription factor (EMT (show ITK Antibodies)-TF).
Data show that Ras protein regulates inhibitor of growth protein 4 (ING4)-thymine-DNA glycosylase (TDG (show TDG Antibodies))-Fas (show FAS Antibodies) protein axis to promote apoptosis resistance in pancreatic cancer.
IL-6 (show IL6 Antibodies) Receptor is overexpressed in glioma, and it can be used for targeted delivery of the therapeutic ING4 to the tumor.
ING4 might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas (show FAS Antibodies)-induced apoptosis in a caspase-8 (show CASP8 Antibodies)-dependent pathway.
Inhibitor of growth (show ING1 Antibodies)-4 promotes IkappaB promoter activation to suppress NF-kappaB (show NFKB1 Antibodies) signaling and innate immunity
Report down-regulation of the inhibitor of growth family member 4 (ING4) in different forms of pulmonary fibrosis.
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins.
inhibitor of growth protein 4
, inhibitor of growth family, member 4
, brain my036 protein
, candidate tumor suppressor p33 ING1 homolog
, ING1-like protein