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ING4 encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. Additionally we are shipping Inhibitor of Growth Family, Member 4 Antibodies (62) and Inhibitor of Growth Family, Member 4 Proteins (8) and many more products for this protein.
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These results demonstrated that overexpression of ING4 can induce the apoptosis of melanoma cells and CD3 (show CD3 ELISA Kits)+ T cells through signaling pathways such as the Fas (show FAS ELISA Kits)/FasL (show FASL ELISA Kits) pathway, and that ING4 gene therapy for melanoma treatment is a novel approach.
Inhibitor of growth (show ING1 ELISA Kits) 4 upregulation plus radiotherapy induced synergistic tumor suppression in SPC (show UCN3 ELISA Kits)-A1 xenografts implanted in athymic nude mice. Thus, the restoration of inhibitor of growth (show ING1 ELISA Kits) 4 function might provide a potential strategy for non-small cell lung cancer radiosensitization.
Results found that ING4 expression was significantly reduced in CRC (show CALR ELISA Kits) tissues and associated with increased lymph node metastasis, advanced TNM stage and poor overall survival. Also, ING4 suppressed CRC (show CALR ELISA Kits) angiogenesis by inhibition of Sp1 (show PSG1 ELISA Kits) expression and transcriptional activity through destabilization and ubiquitin degradation and down-regulation of Sp1 (show PSG1 ELISA Kits) downstream pro-angiogenic factors MMP-2 (show MMP2 ELISA Kits) and COX-2 (show COX2 ELISA Kits).
Low ING4 expression is associated with malignant phenotype and temozolomide chemoresistance in glioblastomas.
ING4 directly binds the Miz1 promoter and is required to induce Miz1 mRNA and protein expression during luminal cell differentiation.
The oncogenic role of miR (show MLXIP ELISA Kits)-330 in Hepatocellular Carcinoma Cells is linked to downregulation of ING4.
ING4 binds double-stranded DNA through its central region with micromolar affinity.
results indicate that the combination of ING4 and PTEN may provide an effective therapeutic strategy for HCC
ING4 can facilitate cancer cell sensitivity to chemotherapy and radiotherapy. Although ING4 loss is observed for many types of cancers, increasing evidences show that ING4 can be used for gene therapy. In this review, the recent progress of ING4 regulating tumorigenesis is discussed
ING4 inhibits CRC (show CALR ELISA Kits) invasion and metastasis probably via a switch from mesenchymal marker N-cadherin (show CDH2 ELISA Kits) to epithelial marker E-cadherin (show CDH1 ELISA Kits) through downregulation of Snail1 (show SNAI1 ELISA Kits) epithelial-mesenchymal transition (EMT (show ITK ELISA Kits))-inducing transcription factor (EMT (show ITK ELISA Kits)-TF).
IL-6 (show IL6 ELISA Kits) Receptor is overexpressed in glioma, and it can be used for targeted delivery of the therapeutic ING4 to the tumor.
ING4 might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas (show FAS ELISA Kits)-induced apoptosis in a caspase-8 (show CASP8 ELISA Kits)-dependent pathway.
Inhibitor of growth (show ING1 ELISA Kits)-4 promotes IkappaB promoter activation to suppress NF-kappaB (show NFKB1 ELISA Kits) signaling and innate immunity
Report down-regulation of the inhibitor of growth family member 4 (ING4) in different forms of pulmonary fibrosis.
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins.
inhibitor of growth protein 4
, inhibitor of growth family, member 4
, brain my036 protein
, candidate tumor suppressor p33 ING1 homolog
, ING1-like protein