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INPP4A encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Additionally we are shipping INPP4A Antibodies (23) and INPP4A Proteins (9) and many more products for this protein.
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Mouse (Murine) INPP4A ELISA Kit for Sandwich ELISA - ABIN481728
Aich, Mabalirajan, Ahmad, Agrawal, Ghosh: Loss-of-function of inositol polyphosphate-4-phosphatase reversibly increases the severity of allergic airway inflammation. in Nature communications 2012
this study shows that the myeloid Inpp4a-knockout mice display impaired bacteria clearance due to decreased inflammatory cytokine production
this study shows that FcgammaRIIb drives the sequential dephosphorylation system comprising SHIP1/2 and Inpp4a, and accelerates phagosome acidification
This study showed that spontaneous Inpp4a mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
These results suggest a novel mechanism of action of resveratrol in attenuating asthma phenotype by downregulating PI3K-Akt pathway via upregulating INPP4A.
INPP4A represents the first signalling protein with a function in neurons to suppress excitotoxic cell death
Purkinje cell loss in the Inpp4a(wbl) mutant is due to glutamate excitotoxicity initiated by the climbing fiber, and that Eaat4 may exert a protective effect.
Study provides the first evidence that inositol polyphosphate 4-phosphatase-1 controls the activation of Akt and thereby cell proliferation, survival and tumorigenesis.
Our findings indicate that upregulation of miR-935 may promote pancreatic cancer cell proliferation and migration and inhibit cell apoptosis by targeting INPP4A.
INPP4A could possibly serve as a candidate gene for alterations associated with asbestos exposure.
Data adds a new etiology to the spectrum of hindbrain malformations in human, and when presented with myoclonic epilepsy may lead to the clinical suspicion of INPP4A defect.
in quiescent cells, the 4-phosphatase colocalized with early and recycling endosomes
The +110832A/G (Thr/Ala) variant of INPP4A was significantly associated with asthma in an Indian population.
This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described.
inositol polyphosphate 4-phosphatase type I
, type I inositol 3,4-bisphosphate 4-phosphatase
, type I inositol-3,4-bisphosphate 4-phosphatase
, inositol polyphosphate-4-phosphatase, type 1
, inositol polyphosphate-4-phosphatase, type I, 107kD
, inositol polyphosphate-4-phosphatase, type I
, inositol polyphosphate-4-phosphatase, type Ia