anti-Inositol-Trisphosphate 3-Kinase C (ITPKC) Antibodies

ITPKC encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. Additionally we are shipping ITPKC Proteins (6) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse ITPKC ITPKC 233011 Q7TS72
ITPKC 80271 Q96DU7
Anti-Rat ITPKC ITPKC 308451 Q80ZG2
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Top anti-ITPKC Antibodies at antibodies-online.com

Showing 10 out of 72 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated ELISA, WB Antibody (1µg/ml) staining of Human Pancreas (A), Heart (B) and Skeletal Muscle (C) lysates (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of ITPKC staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of ITPKC expression in HeLa (A), RT4 (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HT-29 cells, using IP3KC Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ICC, IF, WB ICC/IF Image IP3KC antibody [N3C2], Internal detects IP3KC protein at nucleus by immunofluorescent analysis. Sample: RD cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: IP3KC protein stained by IP3KC antibody [N3C2], Internal , diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 μm. WB Image Sample (30 ug of whole cell lysate) A: Raji 7.5% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometric analysis of CEM cells using ITPKC Antibody (N-term) Cat.-No AP52258PU-N (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin-fixed and paraffin-embedded human skeletal muscle reacted with ITPKC Antibody (N-term) followed which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$537.17
Details
Human Goat Un-conjugated ELISA, WB 100 μg 11 to 14 Days
$610.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB ABIN6274473 staining HT29 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibody. Western blot analysis of extracts from HT-29 cells, using IP3KC antibody. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of ITPKC Antibody in HepG2 cell line lysates (35ug/lane) Formalin-fixed and paraffin-embedded human skeletal muscle reacted with ITPKC Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL 2 to 3 Days
$515.63
Details
Human Mouse Un-conjugated WB Western Blot analysis of ITPKC expression in transfected 293T cell line by ITPKC MaxPab polyclonal antibody.Lane1:ITPKC transfected lysate(75.13 KDa).Lane2:Non-transfected lysate. 50 μL 11 to 12 Days
$440.00
Details

Top referenced anti-ITPKC Antibodies

  1. Human Polyclonal ITPKC Primary Antibody for ELISA, WB - ABIN450059 : Onouchi, Gunji, Burns, Shimizu, Newburger, Yashiro, Nakamura, Yanagawa, Wakui, Fukushima, Kishi, Hamamoto, Terai, Sato, Ouchi, Saji, Nariai, Kaburagi, Yoshikawa, Suzuki, Tanaka, Nagai, Cho, Fujino et al.: ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. ... in Nature genetics 2007 (PubMed)

More Antibodies against ITPKC Interaction Partners

Mouse (Murine) Inositol-Trisphosphate 3-Kinase C (ITPKC) interaction partners

  1. The expression of ITPKC in various ciliated tissues suggest a role for the enzyme either in the development or in the function of these specialized cellular structures.

  2. These data show that the absence of expression of the three isoenzymes of Itpk does not prevent the formation of IP5 and IP6, at least in mouse embryonic fibroblasts.[Itpka, Itpkb, Itpkc]

Human Inositol-Trisphosphate 3-Kinase C (ITPKC) interaction partners

  1. Our findings suggest that ITPKC is a susceptibility gene for bone mineral density (BMD), and rs2607420 may play an important role in the regulation of this gene

  2. This study identified several important polymorphisms in the ITPKC and SLC11A1 genes in Koreans.

  3. Genetic variants of ITPKC may have a potential association with HSCR (Hirschsprung disease) susceptibility and/or developmental diseases related to enteric nervous system development.

  4. this study shows that the KD-associated genetic polymorphism in inositol-triphosphate 3-kinase C (ITPKC) (rs28493229) has important functional consequences, governing ITPKC protein levels and thereby intracellular calcium, which in turn regulates NLRP3 expression and production of IL-1beta and IL-18.

  5. ITPKC polymorphisms are associated with Kawasaki disease.

  6. SNP rs7251246 in ITPKC is associated with the severity of Kawasaki disease

  7. Our results identify a novel polymorphism for renal function and highlight the importance of ITPKC as a key molecule to regulate calcium signaling.

  8. a combinatorial association between ITPKC (rs28493229) and CASP3 (rs113420705) was found in coronary artery lesion formation (P = 0.0227, OR: 3.06)in Taiwanese population

  9. functional studies demonstrated that PPP3CC positively influences the protein level of ITPKC, likely by inhibiting phosphorylation of ITPKC and consequently preventing ITPKC from ubiquitin-mediated protein degradation

  10. Functional single-nucleotide polymorphisms in ITPKC and CASP3 are associated with susceptibility to Kawasaki's disease (KD).

  11. the functional polymorphism rs28493229 in ITPKC significantly contributes to the risk of Kawasaki disease.

  12. The C allele of the ITPKC gene rs2290692 is linked to a significantly higher risk for KD in the Han Chinese population studied.

  13. ITPKC susceptibility in Kawasaki syndrome is related to its synergy with environmental triggers, such as thimerosal, which alter calcium homeostasis and promote oxidative stress.

  14. It was found the G/G genotype and G allele of the inositol 1,4,5-trisphosphate 3-kinase rs28493229 polymorphism may contribute to the risk of cervical squamous cell carcinoma in Taiwanese women.

  15. The study failed to prove any association between SNP rs28493229 of ITPKC gene and Kawasaki disease/coronary artery lesions in Chinese patients.

  16. results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population

  17. Single nucleotide polymorphism rs28493229 in ITPKC contributes to Kawasaki disease susceptibility through induced hyperimmune function reflected in the BCG reactivation.

  18. A statistically significant association was not found between the ITPKC gene single-nucleotide polymorphism rs28493229 and Kawasaki disease or coronary artery lesions in Taiwanese children.

  19. results highlight the potential role of the three isoforms of InsP3 3-kinase as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals

  20. ITPKC acts as a negative regulator of T-cell activation through the Ca2+/NFAT signaling pathway, and the C allele may contribute to immune hyper-reactivity in Kawasaki disease.

ITPKC Antigen Profile

Protein Summary

This gene encodes a member of the inositol 1,4,5-trisphosphate

Gene names and symbols associated with ITPKC

  • inositol-trisphosphate 3-kinase C (ITPKC) antibody
  • inositol-trisphosphate 3-kinase C L homeolog (itpkc.L) antibody
  • inositol-trisphosphate 3-kinase Ca (itpkca) antibody
  • inositol-trisphosphate 3-kinase C (itpkc) antibody
  • inositol 1,4,5-trisphosphate 3-kinase C (LOC100354575) antibody
  • inositol 1,4,5-trisphosphate 3-kinase C (Itpkc) antibody
  • inositol-trisphosphate 3-kinase C (Itpkc) antibody
  • 9130023N17Rik antibody
  • fi30c01 antibody
  • IP3-3KC antibody
  • IP3KC antibody
  • itpkc antibody
  • wu:fi30c01 antibody

Protein level used designations for ITPKC

inositol-trisphosphate 3-kinase C , inositol 1,4,5-trisphosphate 3-kinase C , inositol-trisphosphate 3-kinase C-like , IP3 3-kinase C , IP3K C , insP 3-kinase C , InsP 3 kinase C , IP3K-C

GENE ID SPECIES
100524376 Sus scrofa
468885 Pan troglodytes
494865 Xenopus laevis
534051 Bos taurus
562919 Danio rerio
612489 Canis lupus familiaris
779709 Xenopus (Silurana) tropicalis
100064775 Equus caballus
100354575 Oryctolagus cuniculus
100392537 Callithrix jacchus
100448277 Pongo abelii
100471702 Ailuropoda melanoleuca
100583847 Nomascus leucogenys
233011 Mus musculus
80271 Homo sapiens
308451 Rattus norvegicus
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