Insulin-Like Growth Factor 2 Receptor (IGF2R) ELISA Kits

IGF2R encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. Additionally we are shipping IGF2R Antibodies (199) and IGF2R Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
IGF2R 3482 P11717
IGF2R 16004 Q07113
IGF2R 25151  
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Top IGF2R ELISA Kits at

Showing 9 out of 35 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 78.1 pg/mL 312.5-20000 pg/mL Typical standard curve 96 Tests 13 to 16 Days
Mouse 0.78 pg/mL 3.12-200 pg/mL Typical standard curve 96 Tests 15 to 18 Days
Monkey 0.375 ng/mL 0.625-40 ng/mL   96 Tests 12 to 14 Days
Chicken 0.375 ng/mL 0.625-40 ng/mL   96 Tests 12 to 14 Days
Rabbit 18.75 pg/mL 31.25-2000 pg/mL   96 Tests 12 to 14 Days
Pig 0.375 ng/mL 0.625-40 ng/mL   96 Tests 12 to 14 Days
Sheep 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests 11 to 18 Days
  96 Tests 15 to 18 Days
  96 Tests 15 to 18 Days

Top referenced IGF2R ELISA Kits

  1. Human IGF2R ELISA Kit for Sandwich ELISA - ABIN365230 : Chanprasertyothin, Jongjaroenprasert, Ongphiphadhanakul: The association of soluble IGF2R and IGF2R gene polymorphism with type 2 diabetes. in Journal of diabetes research 2015 (PubMed)

More ELISA Kits for IGF2R Interaction Partners

Human Insulin-Like Growth Factor 2 Receptor (IGF2R) interaction partners

  1. mRNA levels of IGF2R were downregulated in hepatocellular carcinoma (HCC) compared with non-tumor tissue samples and was associated with a worse recurrencefree survival and a lower occurrence of cirrhosis. The IGF2R SNPs rs629849 and rs642588 were not significantly associated with HCC risk, whereas a homozygous IGF2R rs629849 GG genotype was associated with a significantly elevated risk of nonviral liver cirrhosis.

  2. We found significantly elevated levels of soluble CD222 in sera of cancer patients compared to healthy controls irrespective of the type of disease. The urine CD222 levels were increased specifically in breast cancer and multiple myeloma. In contrast to serum, CD222 was present within CD222-positive exosomes in urine.

  3. experiments suggest that knockdown of circulating miR-143-3p may protect against insulin resistance in the setting of MetS via targeting of IGF2R and activation of the insulin signaling pathway

  4. IGF-2R rs9456497 G genotype correlates to detrimental cardiovascular risks in ordinary population which might partially interpret their less preservation of health as compared to long-lived cohort.

  5. M. tuberculosis-initiated human mannose receptor signaling regulates macrophage recognition and vesicle trafficking by gamma Fc receptors, Grb2, and SHP-1.

  6. IGF2R deletion is associated with motor speech disorders, and language delays.

  7. Heterodimers of the SNX-BAR proteins, SNX1, SNX2, SNX5, and SNX6, are the cargo-selective elements that mediate the retrograde transport of CI-MPR from endosomes to the trans-Golgi networ independently of the core retromer trimer.

  8. Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR.

  9. These data suggest the involvement of IGF-2, IGF-1R, IGF-2R and PTEN in temporo-spatial patterning of basic cellular processes (proliferation, differentiation) during normal tooth development.

  10. Findings indicate that IGF2R expression is controlled posttranscriptionally by two factors that associate with Igf2r mRNA and suggest that miR-195 and CUGBP1 dampen IGF signaling by inhibiting IGF2R translation.

  11. Previously characterized disease-causing mutations in IGF2, IGF1R, IGF2R, or IGFALS all were found in the general population but with allele frequencies of <1:30,000.

  12. IGF2R plays a minor role in regulating the activity of IGF1R under a variety of conditions and that due to their high expression levels, IGFBPs are the dominant mechanism to regulating IGF network activation

  13. Data show one single nucleotide polymorphism (SNP) in Fox transcription factor FOXO3 (FOXO3) was significantly associated with longevity, and the six SNPs in proto-oncogene protein AKT1 (AKT1) gene and in IGF-2 Receptor (IGF-2R) gene are not.

  14. CREB plays an important role in the inhibition of IGF2R expression by binding to the IGF2R promoter and further suppresses H9c2 cardiomyoblast cell apoptosis induced by IGF2R signaling under hypoxic conditions.

  15. This study showed that Plasma IGF2R levels were positively correlated with plasma HIV viral load.

  16. IGF2R gene polymorphism and circulating IGF2R are associated with T2DM

  17. The macrophage-specific markers CD163, soluble CD163, and soluble MR are increased in septic patients.

  18. Results show that insulin-like growth factor II (IGF-II) overexpression enhanced the levels of amyloid precursor protein (APP) in SK-N-AS neuroblastoma cells.

  19. IGF2R silencing significantly enhanced the chemo-resistance of NSCLC cell lines to cisplatin treatment.

  20. Report genes involved in trafficking of the mannose 6-phosphate receptors between the trans-Golgi network, endosomes and the plasma membrane.

Mouse (Murine) Insulin-Like Growth Factor 2 Receptor (IGF2R) interaction partners

  1. After 6 weeks of environmental tobacco smoke exposure, the Sirt-1 protein level was decreased and cardiac autophagy was increased in C57BL mice. Furthermore, the IGF2R cardiac hypertrophy signaling pathway was also triggered, although cardiac apoptosis and hypertrophy were not induced.

  2. Selective M6PR down-regulation has a critical role in CD8(+) T cell survival.

  3. Expression of imprinted gene Igf2r was unregulated in haploid androgenetic/gynogenetic blastocysts.

  4. that an elevation in IGF-II receptor levels can influence the expression profiles of transcripts as well as proteins that are involved in AD pathogenesis.

  5. DNA methylation changes were noted in the Igf2r gene during chronic cystitis in a murine model.

  6. Airn expression is both necessary and sufficient to silence Igf2r throughout embryonic stem cell differentiation.

  7. The results excluded a role for spliced and unspliced Airn lncRNA products and for Airn nuclear size and location in silencing Igf2r. Instead, silencing only required Airn transcriptional overlap of the Igf2r promoter, which interferes with RNA polymerase II recruitment in the absence of repressive chromatin.

  8. mannose 6-phosphate/IGF2R knock-down in receptor-positive mouse hepatocytes causes increased cathepsin secretion as well as enhanced cell motility and invasiveness

  9. enhanced CI-MPR expression might improve the efficacy of enzyme replacement therapy in Pompe disease through enhancing receptor-mediated uptake of GAA.

  10. The interaction of sM6P/IGF2R with Plg may be an important regulatory mechanism to inhibit migration of cells using the uPA/uPAR system.

  11. Results demonstrate a novel role for IGF2R as an IFNgamma-inducible microglial protein involved in regulation of HIV and chemokine expression.

  12. Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci Dnmt3a2, and misexpression of Igf2, H19, and Igf2r

  13. The adaptor protein complex 1-mediated transport of MPR300 from endosomes to trans-Golgi network indirectly controls the recycling rate of the receptor between the plasma membrane and endosomes, as demonstrated in mu1A-adaptin-deficient fibroblasts.

  14. Unregulated expression of the imprinted genes H19 and Igf2r in mouse uniparental fetuses

  15. role of N-terminus in regulating fibrinolysis and leukocyte migration

  16. studies demonstrate functional role of insulin-like growth factor-II and its receptor in regulation of early mouse development

  17. there is not a an Mpr300- or Mpr46-dependent pathway of granzyme-mediated killing in internalization of monomeric and complexed granzyme B

  18. Alterations of the Igf2r gene may be involved in both exogenous and endogenous liver carcinogenesis with the different patterns and frequencies

  19. Deficiency of Mpr300 appears to promote cellular proliferation and tumorigenicity but not resistance to allorejection.

  20. IGF-II modulation of cathepsin D routing is IGF-II/M6P receptor mediated

Cow (Bovine) Insulin-Like Growth Factor 2 Receptor (IGF2R) interaction partners

  1. Here we examined the transcriptome of skeletal muscle, liver, kidney, and brain of control and LOS bovine fetuses and found that different tissues within LOS fetuses have perturbations of distinct gene pathways... only a small percent of differentially expressed genes (DEGs), including the imprinted gene IGF2R, could be associated with the neighboring differentially methylated regions

  2. suggest that the insulin like growth factor 2 receptor(IGF2R) gene polymorphisms could be useful genetic markers for dairy production traits in cattle

  3. study hypothesizes that reduced granulosa cell insulin-like growth factor II receptor expression in F2 follicles of Twinner cows may play a role in the development of 2 or more dominant follicles

  4. imprinting of Bos taurus IGF2R is similar to mouse except in placenta, which could indicate an effect of reproductive strategy

  5. Increases in CYP19A1 and FSHR mRNA expression and decreases in IGF2R mRNA expression in follicles of Twinners support the hypothesis that increased follicular development and steroidogenesis result from increased extra-ovarian IGF-1 production.

  6. Sex-sorting procedure by flow cytometry did not affect the overall DNA methylation patterns of the IGF2 and IGF2R genes, although individual variation in their methylation patterns among bulls was observed.

  7. Study demonstrates associations between IGF2R polymorphisms and growth- and body-related traits in cattle.

  8. Data describes the long-term changes to skeletal muscle growth and IGF1, 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.

  9. Expression and binding properties of mannose-6-phosphate receptors CD-MPR and CI-MPR differ during perinatal development in rat liver.

  10. the interaction between uPAR and Man-6-P/IGF2R is a low percentage binding event and that suPAR and full-length uPAR bind the Man-6-P/IGF2R by different mechanisms.

  11. Results describe the crystal structure of the N-terminal 432 residues of the cation-independent mannose 6-phosphate receptor, which encompass three out of the 15 repetitive domains of its extracytoplasmic region.

  12. crystal structure of the N-terminal 432 residues reveals the unique architecture of binding pocket and provides insight into recognition of a variety of mannose-containing sugars

  13. CI-MPR contains a third Man-6-P recognition site that is located in domain 5 and that exhibits lower affinity than the carbohydrate-binding sites present in domains 1-3 and 9

  14. The methylation at Igf-2r imprinting control region showed significant variation in tissues, such as blood, liver, brain, heart and heart, and suggested that Igf-2r imprinting was tissue-specifically regulated.

  15. The role of insulin-like growth factor 2 (IGF2) and the regulation of the IGF2 receptor (IGF2R) during follicular development were studied.

  16. Placental expression of IGF-IIR mRNA was greater for Nuclear transfer-derived than in vivo-derived embryos.

  17. study to assess the mRNA expression of IGF-I, IGF-II, IGF-IR and IGF-IIR in bovine oocytes and different stages of preimplantation embryos

  18. Variable pattern of IGF2R allelic expression in major organs such as the brain, cotyledon, heart, liver, lung, spleen, kidney and intercotyledon was observed using a G/A transition in the 3'UTR of IGF2R

Pig (Porcine) Insulin-Like Growth Factor 2 Receptor (IGF2R) interaction partners

  1. IGF2R is expressed from both parental alleles although differential allelic expression may occur.

  2. A single nucleotide polymorphism was identified by short-oligonucleotide expression profiling between Meishan and white composite swine breeds.

IGF2R Antigen Profile

Antigen Summary

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele.

Gene names and symbols associated with IGF2R

  • insulin like growth factor 2 receptor (IGF2R) antibody
  • insulin-like growth factor 2 receptor (Igf2r) antibody
  • insulin like growth factor 2 receptor (igf2r) antibody
  • AI661837 antibody
  • cd222 antibody
  • CI-MPR antibody
  • cimpr antibody
  • m6p-r antibody
  • M6P/IGF2R antibody
  • MPR1 antibody
  • Mpr300 antibody
  • mpri antibody

Protein level used designations for IGF2R

300 kDa mannose 6-phosphate receptor , CI Man-6-P receptor , CI-MPR , IGF-II receptor , M6P/IGF2 receptor , M6P/IGF2R , M6PR , MPR 300 , cation-independent mannose-6 phosphate receptor , cation-independent mannose-6-phosphate receptor , insulin-like growth factor II receptor , IGF-II/CI-MPR , cation-independent MPR , cation-independent mannose 6-phosphate receptor , mannose-6-phosphate receptor, cation independent , insulin-like growth factor receptor type 2 , cation-independent mannose 6 phosphate receptor , insulin-like growth factor 2 receptor

3482 Homo sapiens
16004 Mus musculus
25151 Rattus norvegicus
281849 Bos taurus
395817 Gallus gallus
397214 Sus scrofa
484067 Canis lupus familiaris
496491 Xenopus (Silurana) tropicalis
100027969 Monodelphis domestica
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