anti-Insulinoma-Associated 1 (INSM1) Antibodies

Human Insulinoma-Associated 1 (INSM1) interaction partners

1. INSM1 is highly expressed in small-cell lung carcinomas.

2. Our results suggest that INSM1 is a useful immunohistochemical marker for diagnosing pancreatic neuroendocrine tumor.

3. INSM1 is a sensitive marker for Merkel cell carcinoma

4. Our data suggest that children with the INSM1 binding site within the CLDN14 risk haplotype have a higher likelihood of hypercalciuria and kidney stones. Enhanced CLDN14 expression may play a role in the pathophysiology of their hypercalciuria.

5. High INSM1 expression is associated with small-cell lung cancer.

6. Suggest that INSM1 is valuable for identification of the high-grade thoracic neuroendocrine carcinomas that are sometimes negative for synaptophysin, chromogranin, and CD56.

7. Solution NMR structure of zinc finger 4 and 5 from human INSM1 has been presented.

8. INSM1 is closely related to the development of high-grade neuroendocrine carcinoma of uterine cervix, and a useful new neuroendocrine marker in conducting its correct and rapid diagnosis

9. Data supports our hypothesis that a positive-feedback loop of sonic hedgehog signaling induced INSM1 through N-myc and INSM1 enhanced N-myc stability contributing to the transformation of human neuroblastoma.

10. Small cell lung cancer tissues were strongly positive for INSM1. INSM1 signal was not detected on normal adjacent tissues from lung cancer patients or normal lung tissues

11. the INSM1-promoter specific conditional replicating adenovirus represents a sensitive diagnostic tool to aid clinicians in the detection of NE tumors.

12. Insulinoma-Associated Protein 1 is a crucial regulator of neuroendocrine differentiation in lung cancer.

13. INSM1 autoantibodies were associated with risk of developing type 1 diabetes.

14. INSM1 expression was significantly increased in Neuroendocrine neoplastic vs nonneoplastic tissue.

15. Both the AR42J cell line and the primary cultured mouse acinar cells support role for INSM1 in pancreatic acinar cell trans-differentiation model.

16. The results suggest that INSM1 up-regulation plays a positive role in HSV-1 replication, probably by binding to the ICP0 promoter.

17. The INSM1 promoter can direct herpes simplex virus thymidine kinase gene expression in a nude mouse model of neuroendocrine cancer and effectively repress tumor growth in response to ganciclovir treatment.

18. Data show that the consistent functional effect of INSM1, either with or without other ITFs, promotes pancreatic duct cell differentiation as well as induces Panc-1 cell cycle arrest.

19. IA-1 gene was shown to be developmentally regulated in fetal pancreatic cells, and its expression pattern is consistent with parallel changes in islet-specific transcription factors during the endocrine differentiation of AR42J cells.

20. IA-1 gene is developmentally expressed in the nervous system and the NeuroD1/E47 transcription factors up-regulate IA-1 gene expression through the proximal E-box element of the IA-1 promoter

Mouse (Murine) Insulinoma-Associated 1 (INSM1) interaction partners

1. An INSM1/RCOR1/2 complex controls the balance of proliferation and differentiation during brain development.

2. INSM1 ectopic expression impairs normal lung development especially in postnatal alveologenesis.

3. Insm1 is the earliest known gene expressed in outer versus inner hair cells, demonstrating that nascent outer hair cells initiate a unique differentiation program in the embryo, much earlier than previously believed.

4. Insm1-dependent Hes1 repression is required for neuroendocrine development.

5. INSM1 interacts with RACK1 protein and facilitates insulin receptor -mediated signaling.

6. Insm1 works to promote endocrine cell differentiation in a pathway that involves Neurog3 and Ripply3

7. Data suggest that IA-2 and IA-2beta play important roles in regulation of circadian rhythm, likely through neurochemical communication among neurons of suprachiasmatic nucleus. [Insm2-beta; IA-2beta; insulinoma-associated protein 2-beta]

8. Insm1 acts in the epigenetic and transcriptional network that controls differentiation of endocrine cells in the anterior pituitary gland, and that it requires the SNAG domain to exert this function in vivo.

9. This study suggested that Insm1 in promoting the transition of progenitors from apical and proliferative to basal, terminal and neuronogenic.

10. isolation, characterization, and identification of an interacting protein, Cbl-associated protein (CAP)

11. IA-1 gene is developmentally expressed in the nervous system and the NeuroD1/E47 transcription factors up-regulate IA-1 gene expression through the proximal E-box element of the IA-1 promoter

12. Pancreatic and intestinal endocrine cells express Insm1 and require Insm1 for their development.

13. The fetal lethality of Insm1 mutant mice is caused by catecholamine deficiency, which highlights the importance of Insm1 in the development of the sympatho-adrenal lineage.

14. in mice and humans, INSM1 is likewise expressed transiently during terminal neurogenic divisions, from late progenitors to nascent neurons, and particularly during symmetric neuronogenic divisions.

15. Insm1 and Nhlh1/NSCL1 are novel HH targets induced by Shh treatment in cultured cerebellar granule cell progenitors.

16. INSM1 is a new zinc-finger transcription factor that modulates insulin gene transcription during early pancreas development.

17. Insulinoma-associated 1 is expressed specifically in progenitors undergoing neurogenic divisions, has a panneurogenic role throughout the brain, and promotes basal progenitor formation in the neocortex.

18. a conserved cis-regulatory sequence associated with Insm1 is bound by Ascl1 in the hindbrain, and Ascl1 is essential for the expression of Insm1 in the ventral hindbrain

Zebrafish Insulinoma-Associated 1 (INSM1) interaction partners

1. Insm1a-deficient embryos were microphthalmic and displayed defects in rod and cone photoreceptor differentiation

2. Analaysis of the data identified Insm1a as a key regulator of retina regeneration and provide a mechanistic understanding of how Insm1a contributes to multiple phases of this process.

3. characterization of two zebrafish Insm1-like genes, insm1a and insm1b, and analysis of their expression patterns during embryonic development

Xenopus laevis Insulinoma-Associated 1 (INSM1) interaction partners

1. insm1 is expressed in regions of the tadpole brain and retina harboring populations of progenitor cells.

2. results reveal that IA1 constitutes a novel player downstream of Xash1 in the formation of a previously unidentified population of Xenopus noradrenergic primary neurons