anti-Insulinoma-Associated 1 (INSM1) Antibodies

Human Insulinoma-Associated 1 (INSM1) interaction partners

1. INSM1 is a reliable marker of neuroendocrine differentiation in primary lung neoplasms

2. INSM1 is a sensitive and specific marker for detection of neuroendocrine tumors in cytology samples independent of primary site.

3. 5'-Iodotubercidin treatment and INSM1 inhibition suppressed extracellular signal-regulated kinase 1/2 (ERK1/2) activity and the AKT signaling pathways required for neuroblastoma cell proliferation.

4. INSM1 holds promise as a neuroendocrine marker that can distinguish Merkel cell carcinoma from its mimickers in the skin.

5. INSM1 functions as a key player in neuroendocrine lung cancer via sonic hedgehog (Shh) signaling that crosstalk with PI3K/AKT and MEK/ERK(1/2) pathway to enhance N-myc stability in neuroendocrine lung cancer.

6. INSM1 is expressed in most of the tumors with neuroendocrine and neuroepithelial differentiation in this study, confirming the diagnostic utility of INSM1 as a novel and sensitive marker of NE/neuroepithelial differentiation.

7. nuclear INSM1 immunostaining may serve as a strong nuclear marker in the brain for neoplasms of neuroendocrine or immature neuronal differentiation, when used in concert with other immunostains

8. INSM1 is a novel sensitive and specific marker for detection of small cell carcinoma of the prostate.

9. specificity of INSM1 for neuroendocrine neoplasms as a group was 100%. INSM1 staining was concordant with surgical pathology specimens in all 20 paired cases

10. Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.

11. INSM1 may be used as a standalone first-line marker of neuroendocrine differentiation for tumors of the head and neck.

12. INSM1 is highly expressed in small-cell lung carcinomas.

13. Our results suggest that INSM1 is a useful immunohistochemical marker for diagnosing pancreatic neuroendocrine tumor.

14. INSM1 is a sensitive marker for Merkel cell carcinoma

15. Our data suggest that children with the INSM1 binding site within the CLDN14 risk haplotype have a higher likelihood of hypercalciuria and kidney stones. Enhanced CLDN14 expression may play a role in the pathophysiology of their hypercalciuria.

16. High INSM1 expression is associated with small-cell lung cancer.

17. Suggest that INSM1 is valuable for identification of the high-grade thoracic neuroendocrine carcinomas that are sometimes negative for synaptophysin, chromogranin, and CD56.

18. Solution NMR structure of zinc finger 4 and 5 from human INSM1 has been presented.

19. INSM1 is closely related to the development of high-grade neuroendocrine carcinoma of uterine cervix, and a useful new neuroendocrine marker in conducting its correct and rapid diagnosis

20. Data supports our hypothesis that a positive-feedback loop of sonic hedgehog signaling induced INSM1 through N-myc and INSM1 enhanced N-myc stability contributing to the transformation of human neuroblastoma.

Mouse (Murine) Insulinoma-Associated 1 (INSM1) interaction partners

1. Forced Insm1 expression in embryonic mouse neocortex causes neural progenitor cell delamination.

2. Insm1, which encodes a zinc finger protein that is transiently expressed in nascent outer hair cells (OHC), consolidates their fate by preventing trans-differentiation into inner hair cells (IHC); in the absence of INSM1, many hair cells that are born as OHCs switch fates to become mature IHCs

3. We conclude that decreases in Insm1 interfere with beta-cell specification during the early postnatal period and impair glucose homeostasis during metabolic stress in adults. Insm1 levels are therefore a factor that can influence the development of diabetes.

4. An INSM1/RCOR1/2 complex controls the balance of proliferation and differentiation during brain development.

5. INSM1 ectopic expression impairs normal lung development especially in postnatal alveologenesis.

6. Insm1 is the earliest known gene expressed in outer versus inner hair cells, demonstrating that nascent outer hair cells initiate a unique differentiation program in the embryo, much earlier than previously believed.

7. Insm1-dependent Hes1 repression is required for neuroendocrine development.

8. INSM1 interacts with RACK1 protein and facilitates insulin receptor -mediated signaling.

9. Insm1 works to promote endocrine cell differentiation in a pathway that involves Neurog3 and Ripply3

10. Data suggest that IA-2 and IA-2beta play important roles in regulation of circadian rhythm, likely through neurochemical communication among neurons of suprachiasmatic nucleus. [Insm2-beta; IA-2beta; insulinoma-associated protein 2-beta]

11. Insm1 acts in the epigenetic and transcriptional network that controls differentiation of endocrine cells in the anterior pituitary gland, and that it requires the SNAG domain to exert this function in vivo.

12. This study suggested that Insm1 in promoting the transition of progenitors from apical and proliferative to basal, terminal and neuronogenic.

13. isolation, characterization, and identification of an interacting protein, Cbl-associated protein (CAP)

14. IA-1 gene is developmentally expressed in the nervous system and the NeuroD1/E47 transcription factors up-regulate IA-1 gene expression through the proximal E-box element of the IA-1 promoter

15. Pancreatic and intestinal endocrine cells express Insm1 and require Insm1 for their development.

16. The fetal lethality of Insm1 mutant mice is caused by catecholamine deficiency, which highlights the importance of Insm1 in the development of the sympatho-adrenal lineage.

17. in mice and humans, INSM1 is likewise expressed transiently during terminal neurogenic divisions, from late progenitors to nascent neurons, and particularly during symmetric neuronogenic divisions.

18. Insm1 and Nhlh1/NSCL1 are novel HH targets induced by Shh treatment in cultured cerebellar granule cell progenitors.

19. INSM1 is a new zinc-finger transcription factor that modulates insulin gene transcription during early pancreas development.

20. Insulinoma-associated 1 is expressed specifically in progenitors undergoing neurogenic divisions, has a panneurogenic role throughout the brain, and promotes basal progenitor formation in the neocortex.

Zebrafish Insulinoma-Associated 1 (INSM1) interaction partners

1. Insm1a-deficient embryos were microphthalmic and displayed defects in rod and cone photoreceptor differentiation

2. Analaysis of the data identified Insm1a as a key regulator of retina regeneration and provide a mechanistic understanding of how Insm1a contributes to multiple phases of this process.

3. characterization of two zebrafish Insm1-like genes, insm1a and insm1b, and analysis of their expression patterns during embryonic development

Xenopus laevis Insulinoma-Associated 1 (INSM1) interaction partners

1. insm1 is expressed in regions of the tadpole brain and retina harboring populations of progenitor cells.

2. results reveal that IA1 constitutes a novel player downstream of Xash1 in the formation of a previously unidentified population of Xenopus noradrenergic primary neurons