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Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. Additionally we are shipping Insulinoma-Associated 1 Kits (5) and Insulinoma-Associated 1 Proteins (5) and many more products for this protein.
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Our data suggest that children with the INSM1 binding site within the CLDN14 (show CLDN14 Antibodies) risk haplotype have a higher likelihood of hypercalciuria and kidney stones. Enhanced CLDN14 (show CLDN14 Antibodies) expression may play a role in the pathophysiology of their hypercalciuria.
High INSM1 expression is associated with small-cell lung cancer.
Suggest that INSM1 is valuable for identification of the high-grade thoracic neuroendocrine carcinomas that are sometimes negative for synaptophysin (show SYP Antibodies), chromogranin, and CD56 (show NCAM1 Antibodies).
Solution NMR structure of zinc finger 4 (show YIPF4 Antibodies) and 5 from human INSM1 has been presented.
INSM1 is closely related to the development of high-grade neuroendocrine carcinoma of uterine cervix, and a useful new neuroendocrine marker in conducting its correct and rapid diagnosis
Data supports our hypothesis that a positive-feedback loop of sonic hedgehog (show SHH Antibodies) signaling induced INSM1 through N-myc (show MYCN Antibodies) and INSM1 enhanced N-myc (show MYCN Antibodies) stability contributing to the transformation of human neuroblastoma (show ARHGEF16 Antibodies).
Small cell lung cancer tissues were strongly positive for INSM1. INSM1 signal was not detected on normal adjacent tissues from lung cancer patients or normal lung tissues
the INSM1-promoter specific conditional replicating adenovirus represents a sensitive diagnostic tool to aid clinicians in the detection of NE tumors.
Insulinoma-Associated Protein 1 is a crucial regulator of neuroendocrine differentiation in lung cancer.
INSM1 autoantibodies were associated with risk of developing type 1 diabetes.
An INSM1/RCOR1 (show Rcor2 Antibodies)/2 complex controls the balance of proliferation and differentiation during brain development.
INSM1 ectopic expression impairs normal lung development especially in postnatal alveologenesis.
Insm1 is the earliest known gene expressed in outer versus inner hair cells, demonstrating that nascent outer hair cells initiate a unique differentiation program in the embryo, much earlier than previously believed.
Insm1-dependent Hes1 (show HES1 Antibodies) repression is required for neuroendocrine development.
INSM1 interacts with RACK1 (show GNB2L1 Antibodies) protein and facilitates insulin receptor (show INSR Antibodies) -mediated signaling.
Insm1 works to promote endocrine cell differentiation in a pathway that involves Neurog3 and Ripply3
Data suggest that IA-2 (show PTPRN Antibodies) and IA-2beta (show PTPRN2 Antibodies) play important roles in regulation of circadian rhythm, likely through neurochemical communication among neurons of suprachiasmatic nucleus. [Insm2 (show INSM2 Antibodies)-beta; IA-2beta (show PTPRN2 Antibodies); insulinoma-associated protein 2 (show INSM2 Antibodies)-beta]
Insm1 acts in the epigenetic and transcriptional network that controls differentiation of endocrine cells in the anterior pituitary gland, and that it requires the SNAG domain to exert this function in vivo.
This study suggested that Insm1 in promoting the transition of progenitors from apical and proliferative to basal, terminal and neuronogenic.
isolation, characterization, and identification of an interacting protein, Cbl (show CBL Antibodies)-associated protein (CAP)
characterization of two zebrafish Insm1-like genes, insm1a and insm1b, and analysis of their expression patterns during embryonic development
insm1 is expressed in regions of the tadpole brain and retina harboring populations of progenitor cells.
results reveal that IA1 constitutes a novel player downstream of Xash1 (show ASCL1 Antibodies) in the formation of a previously unidentified population of Xenopus noradrenergic primary neurons
Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.
insulinoma-associated protein 1
, zinc finger protein IA-1
, insulinoma-associated protein (IA-1)
, insulinoma-associated 1
, insulinoma-associated 1-like protein b
, insuloma-associated 1
, insulinoma-associated protein 1-like
, LOW QUALITY PROTEIN: insulinoma-associated protein 1