INSM1 antibody (N-Term)

Catalog No. ABIN6991197

Product Details anti-INSM1 Antibody

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Binding Specificity: AA 90-140, N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INSM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: IA-1 Antibody is affinity chromatography purified via peptide column.

Immunogen: IA-1 antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human IA-1. The immunogen is located within amino acids 90 - 140 of IA-1.

Isotype: IgG

Application Details

Application Notes: IA-1 antibody can be used for detection of IA-1 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IA-1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IA-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for INSM1

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Alternative Name: IA-1 (INSM1 Products)

Synonyms: IA-1 antibody, IA1 antibody, INSM-1 antibody, Insm1 antibody, fc13a09 antibody, wu:fc13a09 antibody, zINSM-1 antibody, zgc:63866 antibody, INSM1 antibody, ia-1 antibody, zgc:77257 antibody, INSM transcriptional repressor 1 antibody, insulinoma-associated 1 antibody, insulinoma-associated 1b antibody, insulinoma associated 1 antibody, insulinoma associated 1 L homeolog antibody, insulinoma-associated 1a antibody, INSM1 antibody, Insm1 antibody, insm1b antibody, insm1 antibody, insm1.L antibody, insm1a antibody

Background: IA-1 Antibody: IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100 % of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.

Gene ID: 3642

NCBI Accession: NP_002187

UniProt: Q01101