Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) Proteins (ITGAE)

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Additionally we are shipping ITGAE Antibodies (242) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ITGAE 16407 Q60677
Rat ITGAE ITGAE 83577  
ITGAE 3682 P38570
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Top ITGAE Proteins at antibodies-online.com

Showing 5 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
$5,122.60
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
$7,294.44
Details
Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg 15 to 18 Days
$704.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$932.80
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details

ITGAE Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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More Proteins for Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) Interaction Partners

Mouse (Murine) Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) interaction partners

  1. CD103(+) cDCs counterregulated CD11b(+) cDC-mediated Th1 activation directly by producing the immune-suppressive cytokine IL-10.

  2. the data show that CD103 is dispensable for pneumococcal colonization-induced adaptive immune responses in mice

  3. The adoptive transfer of CD103(+) cDC1s to Batf3 deficient animals reversed these observed changes and more importantly could attenuate cellular damage and inflammation in established steatohepatitis.

  4. AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.

  5. Mesenteric lymph node CD11b(-) CD103(+) PD-L1(High) dendritic cell subset probably takes up luminal antigens in the intestine, migrates to MLNs, and highly induces regulatory T cells through TGF-beta activation.

  6. NR4A3 plays an important role in the regulation of CD103+ mDCs by regulating CCR7-dependent cell migration.

  7. Oral treatment with the mucosal adjuvant cholera toxin (CT) induces expression of T cell immunoglobulin and mucin domain containing 4 (TIM-4) on a proportion of CD103+ CD11b+ dendritic cell (DC) in the intestinal lamina propria (LP).

  8. while alphaE (CD103) expression is indeed associated with hTGFbeta1 in vivo, it has little, if any, influence on the course of the psoriasis-like phenotype in K5.hTGFbeta1 transgenic mice

  9. Intestinal CD103(+)CD11b(-) dendritic cells restrain colitis via IFN-gamma-induced anti-inflammatory response in epithelial cells.

  10. Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation.

  11. CD103 on FoxP3+ Treg cells was involved in Treg retention to inflamed skin.

  12. Interleukin-12-producing CD103+ CD11b- CD8+ dendritic cells are responsible for eliciting gut intraepithelial lymphocyte response against Encephalitozoon cuniculi.

  13. An important role for CD103 in the control of airway inflammation in asthma.

  14. Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease.

  15. CXCR3-dependent recruitment of cells to inflamed areas was critical for development of the CD8-positive, CD103-negative T lymphocyte population and pathogen clearance.

  16. CD11c(+) CD103(+) cells of Mycobacterium tuberculosis-infected C57BL/6 but not of BALB/c mice induce a high frequency of interferon-gamma- or interleukin-17-producing CD4(+) cells.

  17. ITGAE(+) cells play a key role in the development of autoimmune diabetes; this is consistent with the hypothesis that ITGAE(+)CD8(+)T effectors initiate the disease process.

  18. IL-2Rbeta-dependent signaling and CD103 functionally cooperate to maintain tolerance in the gut mucosa.

  19. IL-12 production by Batf3-dependent CD103+ dendritic cells is crucial for maintenance of local Th1 immunity against L. major infection.

  20. CD103-CD11b+ dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin.

Human Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) interaction partners

  1. Study data indicate that CD103 engages in dendritic cell (DC)-epithelial cell interactions upon contact with epithelial E-cadherin but is not a major driver of DC adhesion to gastrointestinal epithelia.

  2. CD103-expressing cancer stem cells exosomes acted to guide them to target cancer cells and organs, conferring the higher metastatic capacity of clear cell renal cell carcinoma to lungs.

  3. alphaE gene expression levels were significantly higher in ileal compared with colonic biopsies in both Crohn's disease and Ulcerative colitis, as well as in healthy subjects.

  4. Indeterminate pediatric acute liver failure (iPALF) cases are characterized by a perforin+CD103+CD8+ T-cell predominant hepatic infiltrate consistent with expansion of a Trm CD8+ T-cell phenotype, which is clearly different from noninflammatory causes of PALF.

  5. FGL2 promotes tumor progression in the brain by suppressing CD103-expressing dendritic cell differentiation.

  6. ITGAE+ lymphocytes tended to associate with the epithelial-mesenchymal transition (EMT) with decreased Snail and increased E-cadherin expression accompanied.

  7. Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors.

  8. Pxn binding to the CD103 cytoplasmic tail triggers alphaEbeta7 integrin outside-in signaling that promotes CD8(+) T-cell migratory behavior and effector functions.

  9. AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.

  10. The CD103+CD4+/CD4+ ratio does not accurately discriminate between sarcoidosis and other causes of lymphocytic alveolitis, neither alone nor in combination with the CD4+/CD8+ ratio, and is not a powerful marker for the diagnosis of sarcoidosis.

  11. CD103 expression in human dendritic cells is regulated differentially by retinoic acid and Toll-like receptor ligands.

  12. detected CD103 tumor cells in 41% (16/39) of lymph node-involved adult T-cell leukemia/lymphoma

  13. Levels of GZMA and ITGAE mRNAs in colon tissues can identify patients with UC who are most likely to benefit from etrolizumab; expression levels decrease with etrolizumab administration in biomarker(high) patients.

  14. PD-1(+)CD103(+) CD8 TIL might regain functional antitumor activity, an effect that potentially could be augmented by immune modulation.

  15. This report highlights the diagnostic difficulties and the need of consensus in categorizing clonal CD103(+) lymphocytosis in patients with refractory celiac disease.

  16. Cell-sorting experiments demonstrated that IDO1 expression is found in a subset of CD1a(+)CD14(-)langerin(+) cells, expressing CD103

  17. Report CD103 expression occurs most frequently in gastrointestinal T-cell lymphomas.

  18. Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer.

  19. Using a human CTL system model based on a CD8(+)/CD103(-) T cell clone specific of a lung tumor-associated Ag, we demonstrated that the transcription factors Smad2/3 and NFAT-1 are two critical regulators of this process.

  20. Memory CD103+ CD8 T cells that persist within the brain after an acute infection with vesicular stomatitis virus are bona fide tissue resident memory cells.

ITGAE Protein Profile

Protein Summary

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.

Gene names and symbols associated with ITGAE

  • integrin alpha E, epithelial-associated (Itgae)
  • integrin subunit alpha E (Itgae)
  • integrin subunit alpha E (ITGAE)
  • A530055J10 protein
  • alpha-E1 protein
  • alpha-M290 protein
  • aM290 protein
  • CD103 protein
  • HUMINAE protein

Protein level used designations for ITGAE

integrin alpha M290 , integrin alpha-E , integrin alpha E1, epithelial-associated , integrin, alpha E, epithelial-associated , HML-1 antigen , antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide , integrin alpha-IEL , mucosal lymphocyte 1 antigen

GENE ID SPECIES
16407 Mus musculus
83577 Rattus norvegicus
3682 Homo sapiens
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