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May play a role during maturation and/or organization of muscles cells (By similarity). Additionally we are shipping Integrin beta 1 Binding Protein (Melusin) 2 Antibodies (58) and Integrin beta 1 Binding Protein (Melusin) 2 Proteins (6) and many more products for this protein.
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Studies in mouse show that melusin prevents cardiac dilation during chronic pressure overload by specifically sensing mechanical stress.
Chp-1 and melusin can interact with cochaperones PP5 (show PPP5C ELISA Kits) and Sgt1 (show SUGT1 ELISA Kits) and with each other in an ATP-dependent manner
Identification of a missense mutation in the melusin-encoding ITGB1BP2 gene in a patient with dilated cardiomyopathy
The altered melusin pathways and CDC42 (show CDC42 ELISA Kits) parallel the cardiac function progression during cardiac remodeling post-MI.
Our analysis revealed an extremely low number of variations in the ITGB1BP2 gene in nearly 1000 hypertensive/cardiopathic and healthy individuals, thus suggesting a high degree of conservation of the melusin gene within the populations analyzed
Findings implicate melusin as an enhancer of AKT (show AKT1 ELISA Kits) and ERK (show EPHB2 ELISA Kits) pathways and as a novel player in cardioprotection from ischemia-reperfusion injury.
Multiple hypertrophic stimuli regulate melusin expression predominately in the atria, which may represent a necessary initial step in early adaptive remodelling processes in left ventricular hypertrophy.
controls ERK1/2 (show MAPK1/3 ELISA Kits) activation in heart
PI3K regulates the expression of genes essential for cardiac structure and Z-disc signaling, interacts with melusin, and is critical for Z-disc alignment
Data show that melusin prevents cardiac dilation during chronic pressure overload by specifically sensing mechanical stress.
Melusin directly binds to Hsp90 (show HSP90 ELISA Kits), a ubiquitous chaperone involved in regulating several signaling pathways.
May play a role during maturation and/or organization of muscles cells (By similarity).
integrin beta-1-binding protein 2