Intercellular Adhesion Molecule 4 Proteins (ICAM4)

ICAM4 encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. Additionally we are shipping ICAM4 Antibodies (68) and ICAM4 Kits (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ICAM4 3386 Q14773
ICAM4 78369 Q9ERM2
ICAM4 298702  
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Top ICAM4 Proteins at antibodies-online.com

Showing 9 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
$5,262.31
Details
Human Cells Human Fc Tag 100 μg 14 to 16 Days
$440.65
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg 15 to 18 Days
$656.00
Details
Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg 15 to 18 Days
$688.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Yeast Chimpanzee His tag   1 mg 60 to 71 Days
$2,541.00
Details
Wheat germ Human Un-conjugated   10 μg 11 to 12 Days
$654.29
Details
Escherichia coli (E. coli) Mouse T7 tag,His tag 100 μg 15 to 18 Days
$672.00
Details

ICAM4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,
Mouse (Murine) ,
, ,
Rat (Rattus)

Top referenced ICAM4 Proteins

  1. Human ICAM4 Protein expressed in Human Cells - ABIN2005647 : Bhalla, Chugh, Mehrotra, Rathore, Tousif, Prakash Dwivedi, Prakash, Kumar Samuchiwal, Kumar, Kumar Singh, Ghanwat, Kumar, Das, Mohmmed, Malhotra, Ranganathan: Host ICAMs play a role in cell invasion by Mycobacterium tuberculosis and Plasmodium falciparum. in Nature communications 2015 (PubMed)

More Proteins for Intercellular Adhesion Molecule 4 (ICAM4) Interaction Partners

Human Intercellular Adhesion Molecule 4 (ICAM4) interaction partners

  1. the effect of modulation of the cAMP-PKA-dependent pathway on ICAM-4 receptor activation

  2. Cytometry analysis evidenced a specific expression profile on reticulocytes of SCA infants, with notably an increased expression of the adhesion molecules Lu/BCAM, ICAM-4 and LFA-3, both in percentage of positive cells and in surface density.

  3. ICAM-1 and ICAM-4 play roles in host cell invasion by M. tuberculosis and P. falciparum, respectively.

  4. Seven variant ICAM4 alleles were found, distinct from the wild-type ICAM4 allele (GenBank KF712272), known as LW*05 and encoding LW(a) .

  5. Data from differentiating cultured erythroid precursor cells suggest that RhAG (Rh-associated glycoprotein) knockdown abolishes Rh blood group expression (ICAM4; RhoD [ras homolog family member D]; CD47 Rh-related antigen) in erythroid cells.

  6. Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium.

  7. In a transgenic mouse model of sickle cell disease ICAM-4 is implicated in abnormal adhesiveness of erythrocytes to endothelium.

  8. LWa allele occurs with incidence of 100% of donors in this study, while LWb allele has not been found in Chinese population.

  9. ICAM-4 as the first red blood cells protein ligand of platelets that may have relevant physiological significance

  10. binds to the I domains of the CD11a/CD18 and CD11b/CD18 leukocyte integrins

  11. 12 single amino-acid changes in ICAM4 affected the interaction of ICAM-4 with alpha(V) integrins

  12. LW on sickle but not on normal erythrocytes undergoes increased PKA-dependent serine phosphorylation as a result of activation. The major counter receptor for LW was identified as the alphavbeta3 integrin on ECs

  13. Different integrins bind to different but partly overlapping sites on ICAM4, and ICAM4 may accommodate multiple integrin receptors present on leukocytes, platelets and endothelial cells.

  14. Review. LW antigen contributes to RBC adhesion, thrombosis, and (in sickle cell disease) vaso-occlusion.

  15. We show that ICAM-4 functions as a ligand for the monocyte/macrophage-specific CD11c/CD18. Deletion of the individual immunoglobulin domains of ICAM-4 demonstrated that both its domains contain binding sites for CD11c/CD18.

  16. LW play potentially pathophysiological roles in sickle cell disease

Mouse (Murine) Intercellular Adhesion Molecule 4 (ICAM4) interaction partners

  1. A novel second splice cDNA encodes an ICAM-4 isoform lacking the membrane-spanning domain. Erythroblasts express both isoforms. This new isoform, ICAM-4S, may modulate membrane-associated ICAM-4 binding & regulate erythroblast molecular attachments.

  2. ICAM-4 is critical in erythroblastic island formation via ICAM-4/alpha(V) adhesion

ICAM4 Protein Profile

Protein Summary

This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100\; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with ICAM4

  • intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) (ICAM4)
  • intercellular adhesion molecule 4, Landsteiner-Wiener blood group (Icam4)
  • intercellular adhesion molecule 4 (ICAM4)
  • 1810015M19Rik protein
  • Cd242 protein
  • ICAM-4 protein
  • LW protein

Protein level used designations for ICAM4

CD242 antigen , LW blood group protein , Landsteiner-Wiener blood group antigen a , Landsteiner-Wiener blood group glycoprotein , intercellular adhesion molecule 4 , intercellular adhesion molecule 4 (LW blood group) , LW glycoprotein , Landsteiner-Wiener blood group protein , intercellular adhesion molecule 4, Landsteiner-Wiener blood group

GENE ID SPECIES
3386 Homo sapiens
78369 Mus musculus
455698 Pan troglodytes
514873 Bos taurus
611265 Canis lupus familiaris
100516594 Sus scrofa
298702 Rattus norvegicus
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