GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.
Gene names and symbols associated with IIGP1
interferon inducible GTPase 1 (Iigp1) antibody
Protein level used designations for IIGP1
interferon-gamma-inducible GTPase Ifgga1 protein
, interferon-inducible GTPase 1