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IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. Additionally we are shipping Interferon Regulatory Factor 2 Proteins (15) and Interferon Regulatory Factor 2 Kits (2) and many more products for this protein.
Showing 10 out of 138 products:
Human Polyclonal IRF2 Primary Antibody for ELISA, WB - ABIN184810
Harada, Kitagawa, Tanaka, Yamamoto, Harada, Ishihara, Taniguchi: Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2. in Science (New York, N.Y.) 1993
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Human Polyclonal IRF2 Primary Antibody for WB - ABIN655172
Daley, Lemire, Akhabir, Chan-Yeung, He, McDonald, Sandford, Stefanowicz, Tripp, Zamar, Bosse, Ferretti, Montpetit, Tessier, Becker, Kozyrskyj, Beilby, McCaskie, Musk, Warrington, James, Laprise, Palmer, Paré, Hudson: Analyses of associations with asthma in four asthma population samples from Canada and Australia. in Human genetics 2009
Show all 2 Pubmed References
The effects of IRF2 suppresses non-small cell lung cancer by promoting cell apoptosis, inhibiting cell proliferation and migration ability.
In a genome wide are study to identify acute kidney injury risk in critically ill patients, the locus on chromosome 4, located 150 kb upstream of IRF2 was identified to regulate immunity pathways related to kidney disease risk gene APOL1 (show APOL1 Antibodies). Disruption of IRF-2 has been found to up-regulate the inflammatory response to infection.
Study shows that IRF2 knockdown inhibits growth, colony formation of OCI/AML-2 (show RUNX3 Antibodies), OCI/AML-3 (show RUNX2 Antibodies), and THP-1 (show GLI2 Antibodies) cells. In addition, IRF2 knockdown induces apoptosis of acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)) cells by regulating apoptotic effectors. Further mechanism analysis shows that INPP4B (show INPP4B Antibodies) contributes to the effects of IRF2 on apoptosis and growth of AML (show RUNX1 Antibodies) cells. Thus, IRF2 serves as an important regulator in AML (show RUNX1 Antibodies) by targeting INPP4B (show INPP4B Antibodies).
miR (show MLXIP Antibodies)-450 targets IRF2 and thus supresses lung cancer cell proliferation and invasion.
It might play as a tumor suppressor by regulating P53 (show TP53 Antibodies) signaling in gastric cancer.
the association of IRF2 with susceptibility to systemic lupus erythematosus
Data suggest that interferon (show IFNA Antibodies) regulatory factors 1 and 2 (IRF1 (show IRF1 Antibodies) and IRF2) may serve as potential targets of therapy.
miR (show MLXIP Antibodies)-221 directly inhibits the expression of SOCS3 (show SOCS3 Antibodies) and IRF2.
KGF (show FGF7 Antibodies) could up-regulate IL-7 (show IL7 Antibodies) expression through the STAT1 (show STAT1 Antibodies)/IRF-1 (show IRF1 Antibodies), IRF-2 signaling pathway, which is a new insight in potential effects of KGF (show FGF7 Antibodies) on the intestinal mucosal immune system.
IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3 (show SPINK1 Antibodies)
Data show that HCFC2 (show HCFC2 Antibodies) is a critical component of the IRF1 (show IRF1 Antibodies) and IRF2 transcriptional machinery that regulates Tlr3 (show TLR3 Antibodies) gene expression.
Mysm1 enhanced function of the IRF2 and IRF8 promoters, suggesting that Mysm1 governs the IRFs for hematopoietic stem cell homeostasis.
Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion
Chimeric IRF-2 binds with IRF (show TRIM63 Antibodies)-E motif and VREbeta but not with VREalpha1.
IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3
These results revealed a multi-faceted role of IRF-2 in the function of B cells, particularly B2 cells, through regulating proliferation in an IFNAR (show IFNAR1 Antibodies)-dependent manner and antibody production via up-regulation of Blimp-1 (show PRDM1 Antibodies).
In mice doubly deficient forIRF-2 and CD1d (show CD1D Antibodies), the overall memory phenotype T cell population is contrastingly enlarged.
IRF2 regulates exocytosis in pancreatic acinar cells; defects in this process might be involved in the early phases of acute pancreatitis.
Forced expression of the interferon regulatory factor 2 oncoprotein causes polyploidy and cell death in FDC-P1 myeloid hematopoietic progenitor cells.
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.
regulatory factor 2
, interferon responsive factor 2
, interferon regulatory factor 2b