Interleukin 1 delta Proteins (FIL1d)

Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Additionally we are shipping Interleukin 1 delta Antibodies (96) and Interleukin 1 delta Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FIL1d 54450 Q9QYY1
FIL1d 26525 Q9UBH0
Rat FIL1d FIL1d 311783  
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Top Interleukin 1 delta Proteins at antibodies-online.com

Showing 10 out of 27 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,570.39
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,570.39
Details
Escherichia coli (E. coli) Mouse Un-conjugated IL-36Ra (aa 3-156) (mouse) (rec.)  inhibits IL-36α, IL-36β, IL-36γ-dependent expression of IL-6 in mouse BMDCs.  Method: Bone marrow cells were differentiated into bone marrow-derived dendritic cells (BMDCs) using GM-CSF (20ng/ml) for 10 days. BMDCs were cultured with or without IL-36Ra, IL-36α, IL-36β, IL-36γ, or LPS at indicated concentrations for 72 h. Cell supernatants were then harvested and IL-6 levels determined by ELISA. 10 μg 5 to 8 Days
$268.13
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Escherichia coli (E. coli) Mouse Un-conjugated 50 μg 14 to 16 Days
$440.65
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Escherichia coli (E. coli) Human Un-conjugated   50 μg 4 Days
$377.30
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Escherichia coli (E. coli) Human Un-conjugated 50 μg 14 to 16 Days
$440.65
Details
Escherichia coli (E. coli) Human Un-conjugated   50 μg 2 to 3 Days
$575.00
Details
Escherichia coli (E. coli) Mouse Un-conjugated Validation with Western Blot 25 μg 4 to 8 Days
$330.00
Details
Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg 15 to 18 Days
$800.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details

FIL1d Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , ,
, ,

More Proteins for Interleukin 1 delta (FIL1d) Interaction Partners

Mouse (Murine) Interleukin 1 delta (FIL1d) interaction partners

  1. these data reveal that IL-1Ra and IL-36Ra have opposing effects on the outcome of Pseudomonas aeruginosa keratitis

  2. IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin

  3. Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity

  4. Transcripts for IL-1F5 are significantly increased in the involved skin of bi- and monotransgenic mice compared with their C57BL controls.

  5. IL-1F5 has unique loop conformations for receptor binding specificity

  6. IL-1F5 mediates anti-inflammatory effects through its ability to induce interleukin-4 production, as a consequence of its interaction with orphan receptor single Ig IL-1R-related molecule (SIGIRR)/TIR8.

Human Interleukin 1 delta (FIL1d) interaction partners

  1. The IL36RN gene mutation is not a constant condition in drug-induced AGEP.

  2. The results show, significant correlation of IL36RN mutations with a younger age at psoriasis onset. Psoriasis patients with IL36RN mutations, carried an additional rare variant in either CARD14 or AP1S3, indicating a more complex inheritance.

  3. Letter/Case Report: generalized pustular psoriasis and geographic tongue had a heterozygous IL36RN mutation and IgG2 deficiency.

  4. IL36RN may be the most common disease-causing gene in the patients with generalized pustular psoriasis in the Han population from Sichuan region.

  5. systemic lupus erythematosus patients had significantly decreased serum IL-36Ra levels

  6. IL36RN may be the major disease-causing gene in generalized pustular psoriasis patients in Han population in Sichuan region of China.

  7. IL36RN mutations were strongly linked with early onset and hyponychial pustules, but not with therapeutic efficacy of acitretin or recurrence frequency. Early onset and hyponychial pustules may be specific to IL36RN mutation, however this alone is an insufficient biomarker for acitretin therapy.

  8. Using different blood leukocyte and skin resident cell preparations, and recombinant proteins, the authors have identified that neutrophil elastase, but not other neutrophil derived proteases, cleaves IL-36Ra into its highly active antagonistic form.

  9. A study on the association of IL36RN mutations that affect protein expression and function with phenotype in patients with generalized pustular psoriasis.

  10. The findings indicate that IL36RN mutations do not seem to contribute to the pathogenesis of common, nonpustular forms of psoriasis, but to the rarer pustular manifestations such as GPP, acrodermatitis continua suppurativa of Hallopeau and acute generalized exanthematous pustulosis.

  11. Some cases of geographic tongue are caused by IL36RN mutations, while those lacking mutations are associated with an imbalance in expression between IL-36Ra and IL-36gamma proteins in tongue tissue.

  12. Study data and the previous European study suggest that palmoplantar pustulosis is not associated with mutations of the IL36RN gene.

  13. Case Report: short-term infliximab for treatment of juvenile generalized pustular psoriasis with IL36RN mutation.

  14. The authors present a case of strikingly distinct phenotypes seen in two IL36RN mutation carriers from the same nonconsanguineous pedigree. This mutation it appears may influence the age of onset.

  15. The present study identified IL-36RN in various species and investigated the associations between IL-36RN and cancer prognosis.

  16. We identified a novel homozygous missense mutation in IL36RN in two siblings, and showed the molecular basis of the condition to be both distinct from psoriasis and distinct between the two families studied.

  17. generalized pustular psoriasis and early onset, ever generalized pustular psoriasis (more than two attacks), ever acrodermatitis continua of Hallopeau, inverse psoriasis, and a family history of pustular psoriasis were associated with IL36RN mutation.

  18. IL36RN was identified as strong regulators of skin pathology in both lesional and non-lesional skin samples.

  19. IL36RN missense mutation was not associated with psoriasis.

  20. we report T123M and 115+6T>C mutations, both homozygous in nature, in two Japanese individuals with Zumbusch type of generalized pustular psoriasis.

Interleukin 1 delta (FIL1d) Protein Profile

Protein Summary

Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL- 1R1), that is present in epithelial barriers and takes part in local inflammatory response.

Gene names and symbols associated with Interleukin 1 delta Proteins (FIL1d)

  • interleukin 1 family, member 5 (delta) (Il1f5)
  • interleukin 36 receptor antagonist (IL36RN)
  • interleukin 36 receptor antagonist (Il36rn)
  • AI413231 protein
  • FIL1 protein
  • FIL1(DELTA) protein
  • FIL1D protein
  • Fil1delta protein
  • Il-1h3 protein
  • Il1f5 protein
  • IL1HY1 protein
  • IL1L1 protein
  • IL1RP3 protein
  • IL36RA protein
  • IL36RN protein
  • PSORP protein

Protein level used designations for Interleukin 1 delta Proteins (FIL1d)

IL-1 delta , IL-1F5 , IL-1HY1 , IL-1L1 , interleukin 1 receptor antagonist homolog 1 , interleukin-1 HY1 , interleukin-1 delta , interleukin-1 family member 5 , interleukin-1 homolog 3 , interleukin-1-like protein 1 , interleukin-36 receptor antagonist protein , IL-1 related protein 3 , IL-1F5 (IL-1HY1, FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta) , IL-1ra homolog 1 , IL1F5 (Canonical product IL-1F5a) , interleukin 1 family, member 5 (delta) , interleukin-1 receptor antagonist homolog 1

GENE ID SPECIES
54450 Mus musculus
26525 Homo sapiens
311783 Rattus norvegicus
518514 Bos taurus
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