anti-Interleukin 17 Receptor C (IL17RC) Antibodies

Human Interleukin 17 Receptor C (IL17RC) interaction partners

1. Genetic Variants on IL-17 are associated with development of atherosclerotic diseases.

2. Five SNPs in the IL17RC (and COL6A1) genes were found to be associated with susceptibility to ossification of the posterior longitudinal ligament in Han Chinese patients.

3. IL-17RC rs708567 polymorphism in A/A genotype, G/G genotype, and G/a genotype did not seem to influence RA susceptibility in Tunisian population.

4. methylation of IL17RC could play as a marker in CNV and degeneration of RPE cells in vitro.

5. Interleukin 17A (IL17a) and interleukin-23 (IL-23) - dependent interleukin-17 receptor C (IL-17RC) are expressed by sputum and neutrophils in deltaF508-CFTR protein (F508del) cystic fibrosis patients.

6. human IL-17RC is essential for mucocutaneous immunity to C. albicans but is otherwise largely redundant.

7. results suggested a potential involvement of IL-17RC+CD8+ T cells in pathogenesis of ocular sarcoidosis

8. IL-17RC predisposes to the development of adolescent idiopathic scoliosis in a Chinese Han population.

9. Data show that IL-17RA, IL-17RC, IL-22R1, ERK1/2 MAPK and NF-kappaB pathways are involved in Th17 cytokine-induced proliferation.

10. Overall, our study found a significant association of IL-17RC gene polymorphisms with AIS in a Chinese Han population, indicating IL-17RC gene may be as a susceptibility gene for AIS.

11. IL-17 and its receptor IL-17RC are involved in rheumatoid arthritis synovial fluid-mediated chemotaxis in human lung microvascular endothelial cell culture.

12. IL-17RL exists as multiple isoforms due to extensive alternative splicing. Changes in RNA IL-17RL splicing occur in advanced cancers.

13. The biologic activity of IL-17 is dependent on a complex composed of receptors IL-17RA and IL-17RC.

14. IL-17RC functions as a receptor for both IL-17A and IL-17F; a soluble version of this protein should be an effective antagonist of IL-17A and IL-17F mediated inflammatory diseases.

15. IL-17A-induced IL-6, IL-8, and CCL20 secretion was dependent on both IL-17RA and IL-17RC, which are overexpressed in RA patients.

16. Interleukin-17F is inhibited by the IL-17RC receptor, a combination of soluble IL-17RA/IL-17RC receptors is required for inhibition of the IL-17F/IL-17A activity.

Mouse (Murine) Interleukin 17 Receptor C (IL17RC) interaction partners

1. Study reveals a critical role of IL-17RC in maintaining baseline A20 production and a novel role of the IL-17RC-A20 axis in controlling JNK isoform-dependent tumor-specific homeostatic proliferation.

2. IL-17A and IL-17F exert distinct biological effects during pulmonary infection; the IL-17F/IL-17RC signaling axis has the potential to significantly worsen pathogen-associated inflammation of the lower respiratory tract.

3. Our study shows for the first time that psoriatic inflammation leads to hepatic inflammation which results in dysregulated protein/lipid metabolism through IL-17RC/NFkappaB signaling.

4. Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling.

5. These data show that IL-17R signaling in the lung epithelium plays a critical role in establishing chemokine gradients that are essential for mucosal immunity against pulmonary bacterial pathogens.

6. Interleukin-17 receptor C deficient mice had higher rates of apoptosis in castration-resistant prostate cancer.

7. Data show that signaling in IL-17RC(-/-) fibroblasts required the SEF/IL-17R signaling domain (SEFIR).

8. IL-17RC is essential for mediating the functions of IL-17A, IL-17F, and IL-17A/F both in vitro and in vivo and directly participates in the pathogenesis of central nervous system inflammation.

9. The biologic activity of IL-17 is dependent on a complex composed of receptors IL-17RA and IL-17RC.