anti-Interleukin 17A (IL17A) Antibodies

Human Interleukin 17A (IL17A) interaction partners

1. Serum levels were elevated in diabetic Hepatitis C Virus infected patients.

2. a significant increase of miR26a & IL17 occurs in relapsing - remitting Multiple Sclerosis patients

3. allergen specific immunotherapy decreases IL-17 and increases IL-35 in patients with AR sensitive to house dust mite allergens

4. IL-17 induces recruitment and functional activity of granulocytes in coinfected with schistosomiasis and hepatitis C virus which may contribute to the progress of fibrosis.

5. Results show that IL-17A expression, and IL-17R are increased in neutrophils of autism spectrum disorder (ASD) patients. Further, inflammatory signaling pathways such as such as phospho-NFkappaB, and ROS generating enzymes, i.e. NOX2/iNOS are increased in neutrophils of ASD patients.

6. Mucosal-associated invariant T interleukin 17 (MAITMAIT-17 are present in children with asthma and associated with asthma symptoms.

7. The expression pattern of the IL-17A in chronic obstructive pulmonary distress syndrome samples was increased as compared of those of normal samples, and their main role in the regulation of and p53-fibrinolytic system makes these components as a predictive prominent component in smokers with COPD.

8. involved in the development of intestinal fibrosis through inducing epithelial-mesenchymal transition

9. In anklylosing spondylitis patients, IL-17A regulates osteoblast activity and cell differentiation via JAK2/STAT3 signaling.

10. IL-17A rs2275913 polymorphism is involved in the development of OA in Chinese Han population.

11. The interleukins IL-23/IL-17 immune axis has been detected as an important factor in the immunopathogenesis of ankylosing spondylitis (AS) [Review].

12. Our results suggest that enhanced CXCR4 expression on CD4+ T-cells was positively correlated with increased plasma IL-17A concentrations in patients with AA. In addition, the level of CXCR4 expression on T-cells and IL-17A concentration were both positively correlated with AA severity.

13. confirm that IL-9 promotes inflammation in psoriasis by up-regulating IL-17A production

14. expression of IL-17A, E, and F and their receptors in non-small-cell lung cancer; data suggest that IL-17A, E, F and their receptors IL-17RA, RB, RC may be involved in the pathogenesis of non-small cell lung cancer

15. It appears to be associated with the metastasis-prone phenotype of oral squamous cell carcinoma.

16. Taken together, this study suggests that FGF2 cooperates with IL-17 to promote the pathogenesis of autoimmune arthritis by cooperating with IL-17 to induce inflammatory response.

17. These findings suggest that Foxp3(+) cells, IL-10 and IL-17 play important roles in the immunopathogenesis of cutaneous leishmaniasis and that these roles differ depending on the causal leishmania species and different body compartments.

18. Our data indicate that a distinct inflammatory process accompanies IL17A and CD21L co-expression. Clearly B-cells are involved and their prominence indicates that therapies targeting B-cells, such as rituximab, are likely to be more efficacious towards IL17A+/CD21L+ synovia.

19. IL-17, a pro-inflammatory cytokine, mostly secreted by infiltrated CD4(+) T helper cells, has shown to mediate resistance to anti-VEGF therapies, through recruiting bone marrow derived cells and modulating stromal cells activities including endothelial cells, tumor associated macrophages and cancer associated fibroblasts. [review]

20. Our results suggest that the TT genotype of IL-17A rs3748067 might be a risk factor for TB in Asians; the A allele, as well as the AG and AA+AG genotypes of the rs2275913 polymorphism, might be protective against TB in Caucasians

Horse (Equine) Interleukin 17A (IL17A) interaction partners

1. Data show increased interleukin 17 (IL-17) staining intensity in mediastinal lymph node from chronic recurrent airway obstruction (RAO) horses.

2. cloning and characterization of interleukin-17 expressed gene sequence from mRNA obtained from intestinal tissue and interleukin-23 expressed gene sequence from mRNA obtained from peripheral blood mononuclear cells

3. This study examined effects of in vitro exposure to solutions of hay dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.

4. The acute pulmonary neutrophilia characteristic of recurrent airway obstruction was not associated with an increase in expression of chemokines in pulmonary mononuclear cells from disease-susceptible horses.

Mouse (Murine) Interleukin 17A (IL17A) interaction partners

1. involved in the development of intestinal fibrosis through inducing epithelial-mesenchymal transition

2. Coxiella downregulates IL-17 signaling in a T4BSS-dependent manner in order to escape the macrophage immune response.

3. The requirement of TCF-1 in vivo at stages earlier than double-positive cells to restrain peripheral Th17 immunity by directly binding and inhibiting IL-17 promoter.

4. Mortality is higher and occurs at an early stage of infection in the interleukin (IL)-17A-knockout mice than in the wild-type and IL-17A/F-knockout mice; however, there is no significant difference in the intrapulmonary bacterial counts among the three groups. The IL-17A-knockout group shows higher levels of IL-17F and granulocyte-colony stimulating factor and higher neutrophil count in the bronchoalveolar lavage fluid.

5. Resulted in severe and irreversible disease that, unlike EAE-I, was not abolished by anti-IL-17-mAb.

6. Study in mouse skin wound model found that Vgamma4 T cells were a major source of epidermal IL-17a at the early stages of wounding and were responsible for the delayed wound repair. Moreover, Vgamma4 T cell-derived IL-17a indirectly inhibited Igf-1 production in dendritic epidermal T cells by enhancing epidermal IL-23/IL-1beta expression.

7. Neutralizing IL-17A did not further reduce disease during M. pulmonis infection in BALB/c mice depleted of neutrophils, suggesting that IL-17A requires the presence of pulmonary neutrophils to worsen respiratory pathology.

8. Caspase recruitment domain family member 14 (Card14) deficient mice display attenuated skin inflammation in the imiquimod-induced psoriasis model due to impaired Interleukin-17A (IL-17A) signaling in keratinocytes. Card14 regulates IL-17A signaling by interacting with the ACT1-TRAF6 complex.

9. this paper shows that the increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells

10. data thus indicates that EBV DNA itself acts as a modulator of the Th17 compartment as well as that of regulatory T cell mechanisms. The involvement of TLR9 in the EBV DNA-triggered induction of IL-17A.

11. gammadeltaT17 cells constitutively express chemokine receptors CCR6 and CCR2

12. this paper shows that IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5

13. this study shows that IL-17A negatively regulates lymphangiogenesis in T helper 17 cell-mediated inflammation

14. The present study demonstrated that a high fat diet induces IL-17A expression, which exacerbates the progression of nonalcoholic fatty liver disease by inhibiting fatty acid beta-oxidation and promoting the accumulation of triglycerides (TG).

15. JunB has an essential role in IL-23-dependent pathogenicity of Th17 cells

16. Gamma-delta T cells are a prime source of protumoral IL17A in breast cancer.

17. blocking activin/ACVR2A impaired the potency of hepatic stellate cells to produce collagens in response to IL17s.

18. this study shows the positive effects of IL-17 on the early-stage differentiation and negative effects on the calcification of primary osteoblasts in vitro

19. these data suggest that IL-17A promotes DVT pathogenesis by enhancing platelet activation and aggregation, neutrophil infiltration, and EC activation

20. These findings highlight a regulatory pathway of Tiam1/Rac1 in Th17 cells and suggest that it may be a therapeutic target in multiple sclerosis.

Cow (Bovine) Interleukin 17A (IL17A) interaction partners

1. These results support previous gene transcription studies and extend the observation of increased IL-22 and IL-17A responses in M. bovis-infected animals to the level of protein production.

2. calves, like humans, mount a robust IL-17 response during respiratory syncytial virus infection.

3. Data show that CD4(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 termed Th17 and gammadelta17 cells.

4. IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.

5. IL-17A and IL-17F have a potential to modulate the mammary gland immune response to mastitis-causing pathogens.

6. The results of this study provide evidence of the role of IL-17 in the immunopathology of tuberculosis and support the use of IL-17 as a potential biomarker with predictive value of prognosis in bTB.

Pig (Porcine) Interleukin 17A (IL17A) interaction partners

1. At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8+ T cell, gammadelta T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development.

2. Alterations in the IL-17 regulated pathway of porcine colon in response to dietary supplementation with seaweeds and yeast are reported.

3. conclude that only two subpopulations of porcine WBCs are sources of IL-17 after non-specific stimulation: CD3(+)CD4(+) and CD3(+)gammadeltaTCR(+).

4. Cloning and expression of interleukin-17.

Rhesus Monkey Interleukin 17A (IL17A) interaction partners

1. Data indicate that IL-17/22-producing cells play an important role in maintenance of intestinal mucosa in gluten-sensitive primates.

Guinea Pig Interleukin 17A (IL17A) interaction partners

1. molecular cloning and expression of recombinant IL-17A; homology modeling revealed that the three-dimensional structure resembles that of human IL-17A. The secondary structure predicted showed the presence of one extra helix in the N-terminal region.

Rabbit Interleukin 17A (IL17A) interaction partners

1. one of the interaction sites between IL17A and its receptor IL17RA