anti-Interleukin 17A (IL17A) Antibodies

Human Interleukin 17A (IL17A) interaction partners

1. IL-17A -737T/C, -444A/G, -197G/A, and -121G/A SNPs are not risk factors for rheumatoid arthritis, but the IL-17A TAGA haplotype is a risk factor for systemic lupus erythematosus.

2. this study shows that IL-17A attenuates IFN-lambda expression by inducing suppressor of cytokine signaling expression in airway epithelium

3. highly likely that the pathogenesis of knee osteoarthritis in Chinese Han population is positively related to the genotype AA and allele A of IL-17A

4. The results suggested that elevated IL-17A and IL-9 expressions and decreased levels of adipsin and CCL11 were positively associated with adult asthma.

5. The molecular analysis revealed strong cooperative effects of IL-17A and IL-36 cytokines in regulating target genes, which was dependent on the proteolytic activation of the latter. Together these findings suggest an amplification cycle that can be initiated by IL-17A, involving IL-36 cytokines and immune cell derived proteases and resulting in active IL-36 cytokines which synergize with IL-17A

6. Polymorphisms of the rs3819024 and rs8193037 loci of the IL-17A gene are not associated with the susceptibility to ischemic stroke among ethnic Han Chinese from Guangxi.

7. IL-17A promoted lung tumor growth and angiogenesis.

8. The GTA haplotype of the IL17A SNPs rs4711998, rs8193036 and rs2275913 was associated with osteitis after BCG vaccination.

9. decreased IL17A levels in bronchoalveolar lavage fluid may be a valuable biomarker to identify severe Mycoplasma pneumoniae pneumonia in children.

10. these data demonstrate that Del-1 can negatively regulate IL-17 and its proinflammatory function, thereby limiting airway inflammation in allergic asthmatics, and suggest Del-1 as a potential candidate for prevention and treatment of allergic asthma.

11. Restrictive expression of TCR gammadelta repertoire and alteration expression of IL-17A gene are the important characteristics of gammadelta T cells in acute myocardial infarction patients.

12. These results suggest that the AA genotype at positions rs4711998, rs2275913 and rs3748067 and GG genotype at position rs19744226 were present significantly more frequently in controls than in the patient group and are likely protective factors against brucellosis.

13. Our findings do not support the association of rs763780 and rs2275913 gene polymorphisms in IL-17gene with susceptibility of Iranians with BCC. Increased IL-17A serum levels may still play a role in pathogenesis of BCC.

14. High IL-17A expression is associated with geriatric asthma.

15. Results found that polymorphisms rs2275913 and rs763780 in the IL17A gene are significantly associated with altered risk for chronic obstructive pulmonary disease.

16. The present findings suggest that IL-17A (rs10484879) G/T and IL-17F (rs763780) C/T gene polymorphisms may contribute in pathogenesis of psoriasis.

17. The expression of miR146a and IL17A are positively correlated in human gastric mucosa infected with H. pylori.

18. CD4+ T cells in blood and skin lesions of generalized pustular psoriasis (GPP) patients were characterized by intense hyperproliferation, production of the GPP key mediator, IL-17A, and highly restricted T-cell receptor repertoires with identical T-cell clones in blood and skin lesions, indicating antigen-driven T-cell expansions. The clonally expanded CD4+ T cells were major producers of IL-17A.

19. IL-17 has a role in mediating psoriasis-associated comorbidities [review]

20. IL-17A 197 G/A gene polymorphism and IL-17A serum levels seemed to have a role in pathogenesis of systemic lupus erythematosus.

Horse (Equine) Interleukin 17A (IL17A) interaction partners

1. Data show increased interleukin 17 (IL-17) staining intensity in mediastinal lymph node from chronic recurrent airway obstruction (RAO) horses.

2. cloning and characterization of interleukin-17 expressed gene sequence from mRNA obtained from intestinal tissue and interleukin-23 expressed gene sequence from mRNA obtained from peripheral blood mononuclear cells

3. This study examined effects of in vitro exposure to solutions of hay dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.

4. The acute pulmonary neutrophilia characteristic of recurrent airway obstruction was not associated with an increase in expression of chemokines in pulmonary mononuclear cells from disease-susceptible horses.

Mouse (Murine) Interleukin 17A (IL17A) interaction partners

1. IL17 role in the lung mucous cell hyperplasia caused by respiratory syncytial virus infection.

2. Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL-1beta and IL-17A.

3. study revealed that miR-340 can specifically bind to the 3' untranslated region of mouse IL-17A and downregulate the expression of endogenous IL-17A.

4. revealed that IL-17 induced the infiltration of a specific subtype of macrophages to aggravate fibrosis through an monocyte chemotactic protein-dependent mechanism

5. The IL-17/AK081284/TGFbeta1 signaling pathway mediates high glucose induced collagen production.

6. Using high-throughput sequencing, we investigated the clonal diversity of the T cell receptors (TCRs) of infiltrating IFN-gamma and IL-17A-producing T cells in male and female SjS-susceptible (SjS(s)) C57BL/6.NOD-Aec1Aec2 mice. There were elevated frequencies of IFN-gamma and IL-17A-producing effector T cell populations in female SjS(S) mice compared to male SjS(S) mice.

7. Our findings suggest that Stk24 plays an important role in controlling IL-17-triggered inflammation and autoimmune diseases.

8. The results suggest that IL-17A is involved in the activation of macrophages that are in the process of adopting the heterogeneous profiles of both the M1 and M2 states.

9. this study shows that CCR2 mediates increased susceptibility to post-H1N1 bacterial pneumonia by limiting dendritic cell induction of IL-17

10. The noncanonical pathway of IL-17 production may be important in mucosal defense and is by itself sufficient to control pathogenic Staphylococcus aureus infection at the ocular surface.

11. The results demonstrated that IL-17A influenced neutrophil infiltration by affecting expression of chemokines and adhesion molecules during the early phase of chlamydial lung infection.

12. IL-17A is involved in mediating CD8 T effector response that causes airway epithelial injury and lung allograft rejection after transplantation.

13. Interleukin-17 (IL-17) produced by locally differentiating TH17 cells is an important driver of the activation of inflamed lymph node stromal cells.

14. IL-17A aggravates inflammatory response during Acute myocardial infarction by inducing macrophages infiltration and activating NLRP3 inflammasome through AMPKalpha/p38MAPK/ERK1/2 pathway.

15. that IL-17A is involved in inflammation-evoked mechanical hyperalgesia in AIA even though the inflammatory process is not dependent on IL-17A. Thus the beneficial clinical effect of IL-17A neutralisation in some forms of arthritis is likely to result not only from the interference with the inflammatory process but also from the interference with processes of nociception.

16. IL-17 acts an inhibitory factor in TGF-beta-induced renal fibroblast activation and extracellular matrix synthesis, and sequentially in renal interstitial fibrosis, via down-regulation of Smad-independent pathway (p38MAPK and AKT phosphorylations).

17. involved in the development of intestinal fibrosis through inducing epithelial-mesenchymal transition

18. Coxiella downregulates IL-17 signaling in a T4BSS-dependent manner in order to escape the macrophage immune response.

19. The requirement of TCF-1 in vivo at stages earlier than double-positive cells to restrain peripheral Th17 immunity by directly binding and inhibiting IL-17 promoter.

20. Mortality is higher and occurs at an early stage of infection in the interleukin (IL)-17A-knockout mice than in the wild-type and IL-17A/F-knockout mice; however, there is no significant difference in the intrapulmonary bacterial counts among the three groups. The IL-17A-knockout group shows higher levels of IL-17F and granulocyte-colony stimulating factor and higher neutrophil count in the bronchoalveolar lavage fluid.

Cow (Bovine) Interleukin 17A (IL17A) interaction partners

1. These results support previous gene transcription studies and extend the observation of increased IL-22 and IL-17A responses in M. bovis-infected animals to the level of protein production.

2. calves, like humans, mount a robust IL-17 response during respiratory syncytial virus infection.

3. Data show that CD4(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 termed Th17 and gammadelta17 cells.

4. IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.

5. IL-17A and IL-17F have a potential to modulate the mammary gland immune response to mastitis-causing pathogens.

6. The results of this study provide evidence of the role of IL-17 in the immunopathology of tuberculosis and support the use of IL-17 as a potential biomarker with predictive value of prognosis in bTB.

Pig (Porcine) Interleukin 17A (IL17A) interaction partners

1. At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8+ T cell, gammadelta T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development.

2. Alterations in the IL-17 regulated pathway of porcine colon in response to dietary supplementation with seaweeds and yeast are reported.

3. conclude that only two subpopulations of porcine WBCs are sources of IL-17 after non-specific stimulation: CD3(+)CD4(+) and CD3(+)gammadeltaTCR(+).

4. Cloning and expression of interleukin-17.

Rhesus Monkey Interleukin 17A (IL17A) interaction partners

1. Data indicate that IL-17/22-producing cells play an important role in maintenance of intestinal mucosa in gluten-sensitive primates.

Guinea Pig Interleukin 17A (IL17A) interaction partners

1. molecular cloning and expression of recombinant IL-17A; homology modeling revealed that the three-dimensional structure resembles that of human IL-17A. The secondary structure predicted showed the presence of one extra helix in the N-terminal region.

Rabbit Interleukin 17A (IL17A) interaction partners

1. one of the interaction sites between IL17A and its receptor IL17RA