anti-Interleukin 17A (IL17A) Antibodies

The protein encoded by IL17A is a proinflammatory cytokine produced by activated T cells. Additionally we are shipping IL17A Kits (127) and IL17A Proteins (98) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IL17A 3605 Q16552
IL17A 16171 Q62386
IL17A 301289  
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Top anti-IL17A Antibodies at

Showing 10 out of 411 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated CyTOF, FACS, ICC, IHC, IP, Neut, WB Detection of IL-17 in Human PBMCs by Flow Cytometry. Immunoprecipitation of Human IL-17. 100 μg Log in to see 8 to 9 Days
Mouse Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using IL17A antibody. 100 μL Log in to see 13 to 14 Days
Mouse Goat Un-conjugated CyTOF, FACS, Neut, WB Detection of IL-17 in EL-4 Mouse Cell Line by Flow Cytometry. EL-4 mouse lymphoblast cell line was treated for 16 hours with 50 ng/mL PMA then stained with Goat Anti-Mouse IL-17 Antigen Affinity-purified Polyclonal Antibody. To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin. IL-6 Secretion Induced by IL-17 and Neutralization by Mouse IL-17 Antibody. Recombinant Mouse IL-17. The ND50 is typically 0.05-0.25 ug/mL. 100 μg Log in to see 8 to 9 Days
Cow Rabbit Un-conjugated WB WB Suggested Anti-IL17A Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: MCF7 cell lysate WB Suggested Anti-IL17A  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
Mouse Rabbit Un-conjugated ELISA, WB Western blot analysis of IL-17 using anti- IL-17 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.  Lane : Recombinant Mouse IL-17 Protein 0.5ng After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti- IL-17 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for IL-17 at approximately 30KD. The expected band size for IL-17 is at 30KD. 100 μg Log in to see 4 to 6 Days
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
Human Rabbit Un-conjugated EIA, WB Western blot analysis of IL17A (arrow) using Interleukin-17A (IL17A) Antibody ; 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the IL17A gene. 0.4 mL Log in to see 6 to 8 Days
Human Mouse Un-conjugated IHC, IHC (p), WB 50 μg Log in to see 11 to 14 Days
Human Mouse Biotin FACS, WB Western Blot of Mouse Anti-IL-17A antibody Lane 1: human full length recombinant IL-17A protein Lane 2: mouse full length recombinant IL-17A protein Lane 3: rat full length recombinant IL-17A protein Load: 20 ng/lane Primary antibody: Anti-IL-17A antibody at 1ug/mL for overnight at 4°C 100 μg Log in to see 5 to 7 Days
Rat Rabbit Biotin ELISA, WB Western Blot showing detection of Rat IL-17A. 50ng of Rat IL-17A (Lane 1) was run on a 4-20% gel and transferred to 0.45 µm nitrocellulose. After blocking with 5% Blotto  30 min at 20°C, Anti-Rat IL-17A (RABBIT) Antibody Biotin Conjugated  secondary antibody was used at 1:5000 in Blocking Buffer for Fluorescent Western Blotting . HRP Streptavidin  was used at 1:40,000 in ABIN925618 for 30 min at 20°C and imaged using the Bio-Rad 4000 MP. Arrow indicates correct 15 kDa molecular weight position expected for Rat IL-17A. 100 μg Log in to see 5 to 7 Days

Top referenced anti-IL17A Antibodies

  1. Human Polyclonal IL17A Primary Antibody for CyTOF, FACS - ABIN4900592 : Todd, Simpson, Estis, Torres, Wub: Reference range and short- and long-term biological variation of interleukin (IL)-6, IL-17A and tissue necrosis factor-alpha using high sensitivity assays. in Cytokine 2013 (PubMed)
    Show all 42 Pubmed References

  2. Mouse (Murine) Polyclonal IL17A Primary Antibody for CyTOF, FACS - ABIN4899637 : Otani, Watanabe, Tanigawa, Okazaki, Yamagami, Watanabe, Tominaga, Fujiwara, Oshitani, Arakawa: Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis. in Biochemical and biophysical research communications 2009 (PubMed)
    Show all 11 Pubmed References

  3. Human Polyclonal IL17A Primary Antibody for IF, IHC - ABIN6672244 : Zhang, Zhao, Song, Yang, Zhang, Zhang, Li: Differential Health Effects of Constant versus Intermittent Exposure to Formaldehyde in Mice: Implications for Building Ventilation Strategies. in Environmental science & technology 2018 (PubMed)
    Show all 7 Pubmed References

  4. Mouse (Murine) Polyclonal IL17A Primary Antibody for IF, IHC - ABIN3021082 : Zhang, Mao, Zhou, Cheng, Lin: IL-17A contributes to brain ischemia reperfusion injury through calpain-TRPC6 pathway in mice. in Neuroscience 2014 (PubMed)
    Show all 7 Pubmed References

  5. Human Monoclonal IL17A Primary Antibody for Neut - ABIN786714 : Aarvak, Chabaud, Miossec, Natvig: IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. in Journal of immunology (Baltimore, Md. : 1950) 1999 (PubMed)
    Show all 6 Pubmed References

  6. Human Monoclonal IL17A Primary Antibody for Neut - ABIN786712 : Chabaud, Durand, Buchs, Fossiez, Page, Frappart, Miossec: Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. in Arthritis and rheumatism 1999 (PubMed)
    Show all 6 Pubmed References

  7. Mouse (Murine) Monoclonal IL17A Primary Antibody for ELISA, WB - ABIN2689740 : Coquet, Chakravarti, Kyparissoudis, McNab, Pitt, McKenzie, Berzins, Smyth, Godfrey: Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 4 Pubmed References

  8. Mouse (Murine) Monoclonal IL17A Primary Antibody for ICS, Neut - ABIN1177292 : Prussin, Metcalfe: Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. in Journal of immunological methods 1996 (PubMed)
    Show all 3 Pubmed References

  9. Human Polyclonal IL17A Primary Antibody for ELISA, ICC - ABIN6262537 : Yan, Yang, Han, Feng: Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats. in Molecular medicine reports 2016 (PubMed)
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  10. Human Monoclonal IL17A Primary Antibody for FACS - ABIN4898004 : Coury, Annels, Rivollier, Olsson, Santoro, Speziani, Azocar, Flacher, Djebali, Tebib, Brytting, Egeler, Rabourdin-Combe, Henter, Arico, Delprat: Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion. in Nature medicine 2008 (PubMed)
    Show all 3 Pubmed References

More Antibodies against IL17A Interaction Partners

Human Interleukin 17A (IL17A) interaction partners

  1. Serum levels were elevated in diabetic Hepatitis C Virus infected patients.

  2. a significant increase of miR26a & IL17 occurs in relapsing - remitting Multiple Sclerosis patients

  3. allergen specific immunotherapy decreases IL-17 and increases IL-35 in patients with AR sensitive to house dust mite allergens

  4. IL-17 induces recruitment and functional activity of granulocytes in coinfected with schistosomiasis and hepatitis C virus which may contribute to the progress of fibrosis.

  5. Results show that IL-17A expression, and IL-17R are increased in neutrophils of autism spectrum disorder (ASD) patients. Further, inflammatory signaling pathways such as such as phospho-NFkappaB, and ROS generating enzymes, i.e. NOX2/iNOS are increased in neutrophils of ASD patients.

  6. Mucosal-associated invariant T interleukin 17 (MAITMAIT-17 are present in children with asthma and associated with asthma symptoms.

  7. The expression pattern of the IL-17A in chronic obstructive pulmonary distress syndrome samples was increased as compared of those of normal samples, and their main role in the regulation of and p53-fibrinolytic system makes these components as a predictive prominent component in smokers with COPD.

  8. involved in the development of intestinal fibrosis through inducing epithelial-mesenchymal transition

  9. In anklylosing spondylitis patients, IL-17A regulates osteoblast activity and cell differentiation via JAK2/STAT3 signaling.

  10. IL-17A rs2275913 polymorphism is involved in the development of OA in Chinese Han population.

  11. The interleukins IL-23/IL-17 immune axis has been detected as an important factor in the immunopathogenesis of ankylosing spondylitis (AS) [Review].

  12. Our results suggest that enhanced CXCR4 expression on CD4+ T-cells was positively correlated with increased plasma IL-17A concentrations in patients with AA. In addition, the level of CXCR4 expression on T-cells and IL-17A concentration were both positively correlated with AA severity.

  13. confirm that IL-9 promotes inflammation in psoriasis by up-regulating IL-17A production

  14. expression of IL-17A, E, and F and their receptors in non-small-cell lung cancer; data suggest that IL-17A, E, F and their receptors IL-17RA, RB, RC may be involved in the pathogenesis of non-small cell lung cancer

  15. It appears to be associated with the metastasis-prone phenotype of oral squamous cell carcinoma.

  16. Taken together, this study suggests that FGF2 cooperates with IL-17 to promote the pathogenesis of autoimmune arthritis by cooperating with IL-17 to induce inflammatory response.

  17. These findings suggest that Foxp3(+) cells, IL-10 and IL-17 play important roles in the immunopathogenesis of cutaneous leishmaniasis and that these roles differ depending on the causal leishmania species and different body compartments.

  18. Our data indicate that a distinct inflammatory process accompanies IL17A and CD21L co-expression. Clearly B-cells are involved and their prominence indicates that therapies targeting B-cells, such as rituximab, are likely to be more efficacious towards IL17A+/CD21L+ synovia.

  19. IL-17, a pro-inflammatory cytokine, mostly secreted by infiltrated CD4(+) T helper cells, has shown to mediate resistance to anti-VEGF therapies, through recruiting bone marrow derived cells and modulating stromal cells activities including endothelial cells, tumor associated macrophages and cancer associated fibroblasts. [review]

  20. Our results suggest that the TT genotype of IL-17A rs3748067 might be a risk factor for TB in Asians; the A allele, as well as the AG and AA+AG genotypes of the rs2275913 polymorphism, might be protective against TB in Caucasians

Horse (Equine) Interleukin 17A (IL17A) interaction partners

  1. Data show increased interleukin 17 (IL-17) staining intensity in mediastinal lymph node from chronic recurrent airway obstruction (RAO) horses.

  2. cloning and characterization of interleukin-17 expressed gene sequence from mRNA obtained from intestinal tissue and interleukin-23 expressed gene sequence from mRNA obtained from peripheral blood mononuclear cells

  3. This study examined effects of in vitro exposure to solutions of hay dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.

  4. The acute pulmonary neutrophilia characteristic of recurrent airway obstruction was not associated with an increase in expression of chemokines in pulmonary mononuclear cells from disease-susceptible horses.

Mouse (Murine) Interleukin 17A (IL17A) interaction partners

  1. involved in the development of intestinal fibrosis through inducing epithelial-mesenchymal transition

  2. Coxiella downregulates IL-17 signaling in a T4BSS-dependent manner in order to escape the macrophage immune response.

  3. The requirement of TCF-1 in vivo at stages earlier than double-positive cells to restrain peripheral Th17 immunity by directly binding and inhibiting IL-17 promoter.

  4. Mortality is higher and occurs at an early stage of infection in the interleukin (IL)-17A-knockout mice than in the wild-type and IL-17A/F-knockout mice; however, there is no significant difference in the intrapulmonary bacterial counts among the three groups. The IL-17A-knockout group shows higher levels of IL-17F and granulocyte-colony stimulating factor and higher neutrophil count in the bronchoalveolar lavage fluid.

  5. Resulted in severe and irreversible disease that, unlike EAE-I, was not abolished by anti-IL-17-mAb.

  6. Study in mouse skin wound model found that Vgamma4 T cells were a major source of epidermal IL-17a at the early stages of wounding and were responsible for the delayed wound repair. Moreover, Vgamma4 T cell-derived IL-17a indirectly inhibited Igf-1 production in dendritic epidermal T cells by enhancing epidermal IL-23/IL-1beta expression.

  7. Neutralizing IL-17A did not further reduce disease during M. pulmonis infection in BALB/c mice depleted of neutrophils, suggesting that IL-17A requires the presence of pulmonary neutrophils to worsen respiratory pathology.

  8. Caspase recruitment domain family member 14 (Card14) deficient mice display attenuated skin inflammation in the imiquimod-induced psoriasis model due to impaired Interleukin-17A (IL-17A) signaling in keratinocytes. Card14 regulates IL-17A signaling by interacting with the ACT1-TRAF6 complex.

  9. this paper shows that the increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells

  10. data thus indicates that EBV DNA itself acts as a modulator of the Th17 compartment as well as that of regulatory T cell mechanisms. The involvement of TLR9 in the EBV DNA-triggered induction of IL-17A.

  11. gammadeltaT17 cells constitutively express chemokine receptors CCR6 and CCR2

  12. this paper shows that IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5

  13. this study shows that IL-17A negatively regulates lymphangiogenesis in T helper 17 cell-mediated inflammation

  14. The present study demonstrated that a high fat diet induces IL-17A expression, which exacerbates the progression of nonalcoholic fatty liver disease by inhibiting fatty acid beta-oxidation and promoting the accumulation of triglycerides (TG).

  15. JunB has an essential role in IL-23-dependent pathogenicity of Th17 cells

  16. Gamma-delta T cells are a prime source of protumoral IL17A in breast cancer.

  17. blocking activin/ACVR2A impaired the potency of hepatic stellate cells to produce collagens in response to IL17s.

  18. this study shows the positive effects of IL-17 on the early-stage differentiation and negative effects on the calcification of primary osteoblasts in vitro

  19. these data suggest that IL-17A promotes DVT pathogenesis by enhancing platelet activation and aggregation, neutrophil infiltration, and EC activation

  20. These findings highlight a regulatory pathway of Tiam1/Rac1 in Th17 cells and suggest that it may be a therapeutic target in multiple sclerosis.

Cow (Bovine) Interleukin 17A (IL17A) interaction partners

  1. These results support previous gene transcription studies and extend the observation of increased IL-22 and IL-17A responses in M. bovis-infected animals to the level of protein production.

  2. calves, like humans, mount a robust IL-17 response during respiratory syncytial virus infection.

  3. Data show that CD4(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 termed Th17 and gammadelta17 cells.

  4. IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.

  5. IL-17A and IL-17F have a potential to modulate the mammary gland immune response to mastitis-causing pathogens.

  6. The results of this study provide evidence of the role of IL-17 in the immunopathology of tuberculosis and support the use of IL-17 as a potential biomarker with predictive value of prognosis in bTB.

Pig (Porcine) Interleukin 17A (IL17A) interaction partners

  1. At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8+ T cell, gammadelta T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development.

  2. Alterations in the IL-17 regulated pathway of porcine colon in response to dietary supplementation with seaweeds and yeast are reported.

  3. conclude that only two subpopulations of porcine WBCs are sources of IL-17 after non-specific stimulation: CD3(+)CD4(+) and CD3(+)gammadeltaTCR(+).

  4. Cloning and expression of interleukin-17.

Rhesus Monkey Interleukin 17A (IL17A) interaction partners

  1. Data indicate that IL-17/22-producing cells play an important role in maintenance of intestinal mucosa in gluten-sensitive primates.

Guinea Pig Interleukin 17A (IL17A) interaction partners

  1. molecular cloning and expression of recombinant IL-17A; homology modeling revealed that the three-dimensional structure resembles that of human IL-17A. The secondary structure predicted showed the presence of one extra helix in the N-terminal region.

Rabbit Interleukin 17A (IL17A) interaction partners

  1. one of the interaction sites between IL17A and its receptor IL17RA

IL17A Antigen Profile

Protein Summary

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Gene names and symbols associated with anti-Interleukin 17A (IL17A) Antibodies

  • interleukin 17A (IL17A) antibody
  • interleukin 17A (Il17a) antibody
  • ChIL-17 antibody
  • CTLA-8 antibody
  • Ctla8 antibody
  • IL-17 antibody
  • IL-17A antibody
  • IL-17F antibody
  • Il17 antibody
  • IL17A antibody

Protein level used designations for anti-Interleukin 17A (IL17A) Antibodies

CTLA-8 , cytotoxic T-lymphocyte-associated antigen 8 , cytotoxic T-lymphocyte-associated protein 8 , interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) , interleukin-17A , interleukin 17 , IL-17A , interleukin 17A , IL-17 , interleukin-17 , Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

3605 Homo sapiens
100034142 Equus caballus
16171 Mus musculus
282863 Bos taurus
395111 Gallus gallus
449530 Sus scrofa
472029 Pan troglodytes
481837 Canis lupus familiaris
708123 Macaca mulatta
301289 Rattus norvegicus
100735572 Cavia porcellus
100339322 Oryctolagus cuniculus
100860877 Capra hircus
101103931 Ovis aries
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