anti-Interleukin 17A (IL17A) Antibodies

The protein encoded by IL17A is a proinflammatory cytokine produced by activated T cells. Additionally we are shipping IL17A Kits (128) and IL17A Proteins (95) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IL17A 3605 Q16552
IL17A 16171 Q62386
IL17A 301289  
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Top anti-IL17A Antibodies at

Showing 10 out of 400 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated CyTOF, FACS, ICC, IHC, IP, Neut, WB Detection of IL-17 in Human PBMCs by Flow Cytometry. Immunoprecipitation of Human IL-17. 100 μg Log in to see 8 to 9 Days
Cow Rabbit Un-conjugated WB WB Suggested Anti-IL17A Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: MCF7 cell lysate WB Suggested Anti-IL17A  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
Mouse Goat Un-conjugated CyTOF, FACS, Neut, WB Detection of IL-17 in EL-4 Mouse Cell Line by Flow Cytometry. EL-4 mouse lymphoblast cell line was treated for 16 hours with 50 ng/mL PMA then stained with Goat Anti-Mouse IL-17 Antigen Affinity-purified Polyclonal Antibody. To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin. IL-6 Secretion Induced by IL-17 and Neutralization by Mouse IL-17 Antibody. Recombinant Mouse IL-17. The ND50 is typically 0.05-0.25 ug/mL. 100 μg Log in to see 8 to 9 Days
Mouse Rabbit Un-conjugated ELISA, WB Western blot analysis of IL-17 using anti- IL-17 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.  Lane : Recombinant Mouse IL-17 Protein 0.5ng After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti- IL-17 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for IL-17 at approximately 30KD. The expected band size for IL-17 is at 30KD. 100 μg Log in to see 4 to 6 Days
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
Human Rabbit Un-conjugated EIA, WB Western blot analysis of IL17A (arrow) using Interleukin-17A (IL17A) Antibody ; 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the IL17A gene. 0.4 mL Log in to see 6 to 8 Days
Human Mouse Un-conjugated IHC, IHC (p), WB 50 μg Log in to see 11 to 14 Days
Human Mouse Biotin FACS, WB Western Blot of Mouse Anti-IL-17A antibody Lane 1: human full length recombinant IL-17A protein Lane 2: mouse full length recombinant IL-17A protein Lane 3: rat full length recombinant IL-17A protein Load: 20 ng/lane Primary antibody: Anti-IL-17A antibody at 1ug/mL for overnight at 4°C 100 μg Log in to see 5 to 7 Days
Rat Rabbit Biotin ELISA, WB Western Blot showing detection of Rat IL-17A. 50ng of Rat IL-17A (Lane 1) was run on a 4-20% gel and transferred to 0.45 µm nitrocellulose. After blocking with 5% Blotto  30 min at 20°C, Anti-Rat IL-17A (RABBIT) Antibody Biotin Conjugated  secondary antibody was used at 1:5000 in Blocking Buffer for Fluorescent Western Blotting . HRP Streptavidin  was used at 1:40,000 in ABIN925618 for 30 min at 20°C and imaged using the Bio-Rad 4000 MP. Arrow indicates correct 15 kDa molecular weight position expected for Rat IL-17A. 100 μg Log in to see 5 to 7 Days
Mouse Rat PE FACS   25 μg Log in to see 10 to 12 Days

Top referenced anti-IL17A Antibodies

  1. Human Polyclonal IL17A Primary Antibody for CyTOF, FACS - ABIN4900592 : Todd, Simpson, Estis, Torres, Wub: Reference range and short- and long-term biological variation of interleukin (IL)-6, IL-17A and tissue necrosis factor-alpha using high sensitivity assays. in Cytokine 2013 (PubMed)
    Show all 41 Pubmed References

  2. Mouse (Murine) Polyclonal IL17A Primary Antibody for CyTOF, FACS - ABIN4899637 : Otani, Watanabe, Tanigawa, Okazaki, Yamagami, Watanabe, Tominaga, Fujiwara, Oshitani, Arakawa: Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis. in Biochemical and biophysical research communications 2009 (PubMed)
    Show all 10 Pubmed References

  3. Human Monoclonal IL17A Primary Antibody for Neut - ABIN786712 : Aarvak, Chabaud, Miossec, Natvig: IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. in Journal of immunology (Baltimore, Md. : 1950) 1999 (PubMed)
    Show all 6 Pubmed References

  4. Human Monoclonal IL17A Primary Antibody for - ABIN786713 : Chabaud, Durand, Buchs, Fossiez, Page, Frappart, Miossec: Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. in Arthritis and rheumatism 1999 (PubMed)
    Show all 6 Pubmed References

  5. Human Monoclonal IL17A Primary Antibody for Neut - ABIN786714 : Chabaud, Fossiez, Taupin, Miossec: Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines. in Journal of immunology (Baltimore, Md. : 1950) 1998 (PubMed)
    Show all 6 Pubmed References

  6. Mouse (Murine) Monoclonal IL17A Primary Antibody for ELISA, WB - ABIN2689740 : Coquet, Chakravarti, Kyparissoudis, McNab, Pitt, McKenzie, Berzins, Smyth, Godfrey: Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 4 Pubmed References

  7. Human Monoclonal IL17A Primary Antibody for FACS - ABIN4898004 : Coury, Annels, Rivollier, Olsson, Santoro, Speziani, Azocar, Flacher, Djebali, Tebib, Brytting, Egeler, Rabourdin-Combe, Henter, Arico, Delprat: Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion. in Nature medicine 2008 (PubMed)
    Show all 3 Pubmed References

  8. Mouse (Murine) Monoclonal IL17A Primary Antibody for ICS, Neut - ABIN1177292 : Prussin, Metcalfe: Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. in Journal of immunological methods 1996 (PubMed)
    Show all 3 Pubmed References

  9. Human Polyclonal IL17A Primary Antibody for ELISA, ICC - ABIN6262537 : Yan, Yang, Han, Feng: Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats. in Molecular medicine reports 2016 (PubMed)
    Show all 3 Pubmed References

  10. Human Monoclonal IL17A Primary Antibody for FACS - ABIN4897998 : Yang, Anderson, Baecher-Allan, Hastings, Bettelli, Oukka, Kuchroo, Hafler: IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. in Nature 2008 (PubMed)
    Show all 2 Pubmed References

More Antibodies against IL17A Interaction Partners

Human Interleukin 17A (IL17A) interaction partners

  1. that proliferation potential-related protein promotes esophageal cancer cell proliferation and migration, and suppresses apoptosis by mediating the expression of p53 and IL-17

  2. The pooled estimate revealed an association between IL-17A rs2275913 polymorphism and the risk of gastric cancer (GC) under all genetic models (A vs. G, OR 1.187, 95% CI 1.086-1.297, P < 0.001; GA vs. GG, OR 1.108, 95% CI 1.008-1.218, P = 0.033; AA vs. GG, OR 1.484, 95% CI 1.236-1.781, P < 0.001), while no evidence of association was found with IL-17A rs3748067 or IL-17F rs763780 polymorphisms.

  3. Over-expression of IL-17 and IL-27 are involved in the pathogenesis of liver damage in children with human cytomegalovrius infection.

  4. IL23 and IL17 have roles in the pathogenesis of Tunisian pemphigus foliaceus

  5. our findings supported the association between IL-17 SNPs and the risk of asthma in Chinese Han population from central China. GA genotype of rs3748067 and the C carries (CT+CC) of rs763780 were associated with a higher risk of asthma

  6. Effect of polymorphisms in IL-12B p40, IL-17A and IL-23 A/G genes on the response of psoriatic patients to narrowband UVB.

  7. IL17A and HPSE may promote tumor angiogenesis and cell proliferation and invasion in cervical cancer, possibly via the NF-kappaB signaling pathway.

  8. the results suggest that IL17A (rs2275913) polymorphism is associated with the development of rheumatic heart disease in South Indian population

  9. This study demonstrated the alteration of IL-17 levels in aseptic non-vasculitic cerebral sinovenous thrombosis

  10. In this Brazilian population, TNF and IL17 gene polymorphisms responsible for the expression of important inflammatory cytokines were associated with overall spondyloarthritis and, specifically, with ankylosing spondylitis and psoriatic arthritis, regardless of gender and HLA-B27

  11. The present study demonstrated no association between IL-2 (T-330G), IL-16 (T-295C), and IL-17 (A-7383G) genotypes and CP in an Iranian population.

  12. The single nucleotide polymorphism rs2275913 in the IL-17A gene is associated with susceptibility to viral myocarditis.

  13. IL-17A197AA polymorphism is associated with the risk of colorectal cancer.

  14. our findings demonstrated that the AA genotype from the IL-17A rs2275913 SNP is positively associated with protection to active tuberculosis but related to higher disease severity in the Argentinean population.

  15. The aim of this study was to explore the possible correlations of serum interleukins and soluble ST2 (sST2) protein with clinical features and inflammatory cytokines in rheumatoid arthritis (RA) patients.

  16. Our results from experiments suggest that the effects of IL-17 mediate activation of STAT3 signaling in breast cancer cells. Taken together, our study shows that myeloid-derived suppressor cells can be a new type of prognostic marker in breast cancer patients. Targeting IL-17/Stat3 signaling may be a promising strategy for BC treatment.

  17. This study draws two main conclusions: 1) The presence of IL-17 polymorphism rs2275913 is closely related to a more severe form of the disease and as a result, a higher number of disease-modifying anti rheumatic drugs required to control it, 2) The presence of IL-17 polymorphism rs2275913 may confer a risk of developing rheumatoid arthritis in Mexican carriers

  18. the expression of IFN-gamma and IL-17 was also suppressed by IRAK1/4 inhibitor both in active Behcet's patients and in normal subjects.

  19. Polymorphisms of IL-17 are associated with host susceptibility to some bacterial pathogen. [review]

  20. secreted IL-17A is not responsible for the second hit in acute pancreatitis

Horse (Equine) Interleukin 17A (IL17A) interaction partners

  1. Data show increased interleukin 17 (IL-17) staining intensity in mediastinal lymph node from chronic recurrent airway obstruction (RAO) horses.

  2. cloning and characterization of interleukin-17 expressed gene sequence from mRNA obtained from intestinal tissue and interleukin-23 expressed gene sequence from mRNA obtained from peripheral blood mononuclear cells

  3. This study examined effects of in vitro exposure to solutions of hay dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.

  4. The acute pulmonary neutrophilia characteristic of recurrent airway obstruction was not associated with an increase in expression of chemokines in pulmonary mononuclear cells from disease-susceptible horses.

Mouse (Murine) Interleukin 17A (IL17A) interaction partners

  1. gammadeltaT17 cells constitutively express chemokine receptors CCR6 and CCR2

  2. this paper shows that IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5

  3. this study shows that IL-17A negatively regulates lymphangiogenesis in T helper 17 cell-mediated inflammation

  4. The present study demonstrated that a high fat diet induces IL-17A expression, which exacerbates the progression of nonalcoholic fatty liver disease by inhibiting fatty acid beta-oxidation and promoting the accumulation of triglycerides (TG).

  5. JunB has an essential role in IL-23-dependent pathogenicity of Th17 cells

  6. Gamma-delta T cells are a prime source of protumoral IL17A in breast cancer.

  7. blocking activin/ACVR2A impaired the potency of hepatic stellate cells to produce collagens in response to IL17s.

  8. this study shows the positive effects of IL-17 on the early-stage differentiation and negative effects on the calcification of primary osteoblasts in vitro

  9. these data suggest that IL-17A promotes DVT pathogenesis by enhancing platelet activation and aggregation, neutrophil infiltration, and EC activation

  10. These findings highlight a regulatory pathway of Tiam1/Rac1 in Th17 cells and suggest that it may be a therapeutic target in multiple sclerosis.

  11. DAPK deficiency leads to excess HIF-1a accumulation, enhanced IL-17 expression and exacerbated experimental autoimmune encephalomyelitis.

  12. decreased COX-2 and IL-17 levels were observed in both groups treated with Nintedanib in the prostate anterior lobe. Thus, we concluded that Nintedanib was effective in delaying tumor progression and, despite not directly acting on inflammation, Nintedanib may adversely affect inflammatory pathways, favoring prostate cancer delay

  13. In studies of mouse and human pancreatic tumors and precursors, we found that immune cell-derived IL17 regulated development of tuft cells and stem cell features of pancreatic cancer cells via increased expression of DCLK1, POU2F3, ALDH1A1, and IL17RC.

  14. The reaction of IL-17A in the acute lung injury induced by LPS is stronger than that by PQ.

  15. IL17A promoted osteoblast differentiation and calcification in a partly AKT2dependent manner in MC3T3E1 cells in vitro, possibly reflecting compensation by other signaling pathways. The results of the present study may offer novel perspectives to guide the clinical strategy for the prevention and treatment of periodontitis

  16. Mechanistically, CREB, activated by CD3-PKC- signaling, plays a key role in regulating Th17 cell differentiation, at least in part through directly binding to the Il17-Il17f gene locus.

  17. Data show that interleukin-17 (IL-17) and fungal candidalysin amplify inflammation in a self-reinforcing feed-forward loop.

  18. The data indicate that IL-17A contributes to augmented responses to ozone in db/db mice. Furthermore, IL-17A appears to act at least in part by inducing expression of gastrin-releasing peptide receptor.

  19. miR203 expression may be upregulated by IL17 stimulation, and miR203 is a positive regulator of IL17induced VEGF secretion.

  20. IL-17 contributes to lung obliterative bronchiolitis pathogenesis through regulating macrophages function

Cow (Bovine) Interleukin 17A (IL17A) interaction partners

  1. These results support previous gene transcription studies and extend the observation of increased IL-22 and IL-17A responses in M. bovis-infected animals to the level of protein production.

  2. calves, like humans, mount a robust IL-17 response during respiratory syncytial virus infection.

  3. Data show that CD4(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 termed Th17 and gammadelta17 cells.

  4. IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.

  5. IL-17A and IL-17F have a potential to modulate the mammary gland immune response to mastitis-causing pathogens.

  6. The results of this study provide evidence of the role of IL-17 in the immunopathology of tuberculosis and support the use of IL-17 as a potential biomarker with predictive value of prognosis in bTB.

Pig (Porcine) Interleukin 17A (IL17A) interaction partners

  1. At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8+ T cell, gammadelta T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development.

  2. Alterations in the IL-17 regulated pathway of porcine colon in response to dietary supplementation with seaweeds and yeast are reported.

  3. conclude that only two subpopulations of porcine WBCs are sources of IL-17 after non-specific stimulation: CD3(+)CD4(+) and CD3(+)gammadeltaTCR(+).

  4. Cloning and expression of interleukin-17.

Rhesus Monkey Interleukin 17A (IL17A) interaction partners

  1. Data indicate that IL-17/22-producing cells play an important role in maintenance of intestinal mucosa in gluten-sensitive primates.

Guinea Pig Interleukin 17A (IL17A) interaction partners

  1. molecular cloning and expression of recombinant IL-17A; homology modeling revealed that the three-dimensional structure resembles that of human IL-17A. The secondary structure predicted showed the presence of one extra helix in the N-terminal region.

Rabbit Interleukin 17A (IL17A) interaction partners

  1. one of the interaction sites between IL17A and its receptor IL17RA

IL17A Antigen Profile

Protein Summary

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Gene names and symbols associated with anti-Interleukin 17A (IL17A) Antibodies

  • interleukin 17A (IL17A) antibody
  • interleukin 17A (Il17a) antibody
  • ChIL-17 antibody
  • CTLA-8 antibody
  • Ctla8 antibody
  • IL-17 antibody
  • IL-17A antibody
  • IL-17F antibody
  • Il17 antibody
  • IL17A antibody

Protein level used designations for anti-Interleukin 17A (IL17A) Antibodies

CTLA-8 , cytotoxic T-lymphocyte-associated antigen 8 , cytotoxic T-lymphocyte-associated protein 8 , interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) , interleukin-17A , interleukin 17 , IL-17A , interleukin 17A , IL-17 , interleukin-17 , Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

3605 Homo sapiens
100034142 Equus caballus
16171 Mus musculus
282863 Bos taurus
395111 Gallus gallus
449530 Sus scrofa
472029 Pan troglodytes
481837 Canis lupus familiaris
708123 Macaca mulatta
301289 Rattus norvegicus
100735572 Cavia porcellus
100339322 Oryctolagus cuniculus
100860877 Capra hircus
101103931 Ovis aries
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