anti-Interleukin 17A (IL17A) Antibodies

Human Interleukin 17A (IL17A) interaction partners

1. Serum IL-23 (show IL23A Antibodies) and IL-17 levels were elevated in patients with aneurysmal subarachnoid hemorrhage (aSAH (show ASAH1 Antibodies)) showing upregulation of IL-23 (show IL23A Antibodies)/IL-17 inflammatory axis after aSAH (show ASAH1 Antibodies). Serum IL-23 (show IL23A Antibodies) and IL-17 showed differential correlations with post hemorrhagic complications and no correlation with clinical outcome.

2. More prominent IL-17 and IFN-gamma (show IFNG Antibodies) production by all lymphocyte subsets in Behcet disease (BD) might be associated with the increased innate responses, early tissue neutrophil infiltrations and late adaptive immunity in BD.

3. Data showed that IL-17A levels were sustained in respiratory samples from cystic fibrosis (show S100A8 Antibodies) patients infected by P. aeruginosa. IL-17 mediated-immunity plays a double-edged found during chronic airways infection: in one hand, it contributes to the control of P. aeruginosa burden, modulating host resistance, while, on the other, it alters host tolerance, propagating exacerbated pulmonary neutrophilia and tissue remodeling.

4. gamma delta T cells, rather than Th17cells, are the principal producers of IL-17 in acute gouty arthritis patients during the acute gout flares.

5. In dermatomyositis muscle specimens, IL-4 (show IL4 Antibodies) and IFN-g (show IFNG Antibodies) levels were positively correlated, while no correlation was observed between IL-17 and the other two cytokines. Moreover, IL-4 (show IL4 Antibodies) and IFNg (show IFNG Antibodies) levels were significantly negative correlated with muscle strength grades for the deltoid muscle

6. high expression of both IL17A and IL32 (show IL32 Antibodies) leads to enhancement of T cell responses in breast tumors

7. IL-17 responds to human Vgamma9Vdelta2 T lymphocytes by TLR-activated plasmacytoid dendritic cells

8. data suggest that suppression of IL-17 A production as one of the mechanisms underlying the beneficial effect of first-line disease-modifying treatments is stronger in glatiramer acetate than in interferon-beta (show IFNB1 Antibodies)

9. There was a close correlation between the expression of IL-17 and syndecan-1 (show SDC1 Antibodies) in nasal mucosa epithelial cells, glandular epithelial cells, and inflammatory cells, suggesting that IL-17 and syndecan-1 (show SDC1 Antibodies) may play a role, and interact with each other, in the pathogenesis of non- eosinophilic chronic rhinosinusitis with nasal polyps.

10. Findings indicate that IL17A -197 G/A and IL23R (show IL23R Antibodies) H3Q are not associated with susceptibility to MM. However, IL-17 and IL-23R (show IL23R Antibodies) polymorphisms may affect severity, bone lesions, and extra-medullary disease in patients with MM.

Horse (Equine) Interleukin 17A (IL17A) interaction partners

1. Data show increased interleukin 17 (IL-17) staining intensity in mediastinal lymph node from chronic recurrent airway obstruction (RAO (show AOC2 Antibodies)) horses.

2. cloning and characterization of interleukin-17 expressed gene sequence from mRNA obtained from intestinal tissue and interleukin-23 expressed gene sequence from mRNA obtained from peripheral blood mononuclear cells

3. This study examined effects of in vitro exposure to solutions of hay (show GTF2H5 Antibodies) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.

Mouse (Murine) Interleukin 17A (IL17A) interaction partners

1. The hormone levels are significantly reduced and lymphocytic infiltration in the lacrimal gland in ovariectomized mice, whereas the frequency of Th17 cells in the blood and spleen and IL-17A and IL-23 (show IL23A Antibodies) expression in the lacrimal glands are increased, leading to reduced tear production and positive fluorescein staining in the cornea.

2. the results suggest that IL-17A induces podocyte injury by activating the NLRP3 (show NLRP3 Antibodies) inflammasome and IL-1beta (show IL1B Antibodies) secretion and contributes to disruption of the kidney's filtration system.

3. These results suggest that a low concentration of IL-17A is likely to promote autophagic activity via activating RANKL (show TNFSF11 Antibodies)-JNK (show MAPK8 Antibodies) pathway during osteoclastogenesis.

4. study shows that IL-17A plays an important role in comorbid depression associated with psoriatic inflammation, where both NFkappaB and p38MAPK (show MAPK14 Antibodies) pathways play significant roles via upregulation of inflammatory mediators in the brain

5. the present study demonstrated that IL-17A crucially regulated the wound healing process and that accelerated neutrophil accumulation caused by IL-17A led to the delayed wound repair.

6. The results emphasize the importance of IL-17 in experimental autoimmune myasthenia gravis development and that IL-17 independent pathways drive the autoimmune reaction.

7. In estrogen receptor (show ESR1 Antibodies) negative breast cancer cells targeting of IL-17A inhibited PDL1 (show CD274 Antibodies) expression in the tumor microenvironment, decreasing the percentage of Treg cells in tumor-infiltrating lymphocytes, and promoting CD4 (show CD4 Antibodies)+ and CD8 (show CD8A Antibodies)+ T cells to secrete interferon gamma (show IFNG Antibodies).

8. Report provides evidence that IL-17 can promote Lewis lung carcinoma growth through inhibition of myeloid-derived suppressor cells apoptosis, which maybe dependent on ERK1/2 signaling pathway.

9. Suggest that the IL-17A/IL-10 (show IL10 Antibodies)/STAT3 (show STAT3 Antibodies) signaling pathway plays a crucial role in the pathogenesis of hepatic fibrosis by suppressing hepatocellular autophagy and that blocking this pathway may provide therapeutic benefits for the treatment of hepatic fibrosis.

10. these data provide novel insight into a dynamic IL-17A-CXCR2 (show CXCR2 Antibodies)-neutrophil axis during acute segmented filamentous bacteria colonization and demonstrate a central role for neutrophils in limiting segmented filamentous bacteria expansion

Cow (Bovine) Interleukin 17A (IL17A) interaction partners

1. calves, like humans, mount a robust IL-17 response during respiratory syncytial virus infection.

2. Data show that CD4 (show CD4 Antibodies)(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 termed Th17 and gammadelta17 cells.

3. IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.

4. IL-17A and IL-17F (show IL17F Antibodies) have a potential to modulate the mammary gland immune response to mastitis-causing pathogens.

5. The results of this study provide evidence of the role of IL-17 in the immunopathology of tuberculosis and support the use of IL-17 as a potential biomarker with predictive value of prognosis in bTB.

Pig (Porcine) Interleukin 17A (IL17A) interaction partners

1. At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8 (show CD8A Antibodies)+ T cell, gammadelta T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development.

2. Alterations in the IL-17 regulated pathway of porcine colon in response to dietary supplementation with seaweeds and yeast are reported.

3. conclude that only two subpopulations of porcine WBCs are sources of IL-17 after non-specific stimulation: CD3 (show CD3 Antibodies)(+)CD4 (show CD4 Antibodies)(+) and CD3 (show CD3 Antibodies)(+)gammadeltaTCR(+).

4. Cloning and expression of interleukin-17.

Rhesus Monkey Interleukin 17A (IL17A) interaction partners

1. Data indicate that IL-17/22-producing cells play an important role in maintenance of intestinal mucosa in gluten-sensitive primates.

Guinea Pig Interleukin 17A (IL17A) interaction partners

1. molecular cloning and expression of recombinant IL-17A; homology modeling revealed that the three-dimensional structure resembles that of human IL-17A. The secondary structure predicted showed the presence of one extra helix in the N-terminal region.

Rabbit Interleukin 17A (IL17A) interaction partners

1. one of the interaction sites between IL17A and its receptor IL17RA (show IL17RA Antibodies)