Interleukin 17A Proteins (IL17A)

The protein encoded by IL17A is a proinflammatory cytokine produced by activated T cells. Additionally we are shipping IL17A Antibodies (508) and IL17A Kits (114) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IL17A 3605 Q16552
IL17A 16171 Q62386
IL17A 301289  
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Top IL17A Proteins at

Showing 10 out of 94 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 4 to 6 Days
Escherichia coli (E. coli) Mouse Un-conjugated 100 μg Log in to see 4 to 6 Days
Escherichia coli (E. coli) Rat Un-conjugated 100 μg Log in to see 4 to 6 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Escherichia coli (E. coli) Mouse Un-conjugated   10 μg Log in to see 10 to 12 Days
HEK-293 Cells Human Un-conjugated 50 μg Log in to see 2 to 3 Days
Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 10 to 12 Days
Escherichia coli (E. coli) Human Un-conjugated   1 mg Log in to see 2 to 3 Days
Escherichia coli (E. coli) Human Un-conjugated   25 μg Log in to see 10 to 12 Days

IL17A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , , ,
, ,
Mouse (Murine) , , , ,

Rat (Rattus) ,

Top referenced IL17A Proteins

  1. Human IL17A Protein expressed in Escherichia coli (E. coli) - ABIN413453 : Bérubé, Roussel, Nattagh, Rousseau et al.: Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas ... in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 Pubmed References

  2. Rat (Rattus) IL17A Protein expressed in Escherichia coli (E. coli) - ABIN413456 : Arif, Moore, Marks, Bouckenooghe, Dayan, Planas, Vives-Pi, Powrie, Tree, Marchetti, Huang, Gurzov, Pujol-Borrell, Eizirik, Peakman: Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death. in Diabetes 2011 (PubMed)

  3. Rat (Rattus) IL17A Protein expressed in Escherichia coli (E. coli) - ABIN5570899 : Yao, Weng, Zhang, Feng, Lin, Yao: Interleukin-17A Acts to Maintain Neuropathic Pain Through Activation of CaMKII/CREB Signaling in Spinal Neurons. in Molecular neurobiology 2016 (PubMed)

More Proteins for Interleukin 17A (IL17A) Interaction Partners

Human Interleukin 17A (IL17A) interaction partners

  1. In this ancillary study, baseline serum IL-17A concentration is the only Th17/IL-17 related factor that was significantly associated with the response of patients with metastatic colorectal cancer to bevacizumab. But this main significant result is highly dependent on one case which, if left out, weakens the data.

  2. downregulation of miR (show MLXIP Proteins)-20a-5p is caused by promoter hypermethylation. MiR (show MLXIP Proteins)-20a-5p could also suppress the production of IL-17 by targeting OSM (show OSM Proteins) and CCL1 (show CCL1 Proteins) production in CD4 (show CD4 Proteins)(+) T cells in patients with active VKH.

  3. No significant association between two single nucleotide polymorphisms, rs8193036 and rs2275913 in the IL17A promoter, and susceptibility to chronic viral hepatitis C and/or B and disease progression to liver cirrhosis in the Kazakh population was found.

  4. IL17(+) neutrophils constitute a large portion of IL17-producing cells in human gastric cancer. Proinflammatory IL17 is a critical mediator of the recruitment of neutrophils into the invasive margin by CXC chemokines

  5. The results of the present study suggest a lack of association between the rs2275913 polymorphism in the IL17A gene and the presence of HTLV-1-associated myelopathy/tropical spastic paraparesis.

  6. The results suggest the possible involvement of the polymorphisms of IL17A G197A (rs2275913) and IL17F (show IL17F Proteins) T7488C (rs763780) in the susceptibility to chronic Chagas disease and in development and progression of cardiomyopathy.

  7. Data show that granulocyte-and-monocyte apheresis (GMA (show MAG Proteins)) successfully removed interleukin 17A (IL-17A)-producing monocytes from blood.

  8. IL-17A acts on vessel and cardiac cells, leading to inflammation, coagulation and thrombosis. [review]

  9. The IL-17A rs2275913 (-197G>A) polymorphism decreased the risk of post-bronchiolitis asthma at 11-13 years of age, but not earlier in life, in the present prospective, long-term follow-up study.

  10. Our data provide the first evidence that the IL-17A rs4711998 genetic variant may contribute to HBV-related liver cirrhosis susceptibility in a Chinese population.

Horse (Equine) Interleukin 17A (IL17A) interaction partners

  1. Data show increased interleukin 17 (IL-17) staining intensity in mediastinal lymph node from chronic recurrent airway obstruction (RAO (show AOC2 Proteins)) horses.

  2. cloning and characterization of interleukin-17 expressed gene sequence from mRNA obtained from intestinal tissue and interleukin-23 expressed gene sequence from mRNA obtained from peripheral blood mononuclear cells

  3. This study examined effects of in vitro exposure to solutions of hay (show GTF2H5 Proteins) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.

Mouse (Murine) Interleukin 17A (IL17A) interaction partners

  1. these data provide novel insight into a dynamic IL-17A-CXCR2 (show CXCR2 Proteins)-neutrophil axis during acute segmented filamentous bacteria colonization and demonstrate a central role for neutrophils in limiting segmented filamentous bacteria expansion

  2. Transient AIEC colonization in IL-17 KO mice resulted in increased intestinal epithelial damage, systemic bacterial burden and mortality compared with controls. IL-17 is required for the induction of IL-22 (show IL22 Proteins) during AIEC strain E. coli LF82 colonization. IL-17 plays a protective role in AIEC strain E. coli LF82 induced colitis by promoting IL-22 (show IL22 Proteins) secretion.

  3. after orthotopic lung transplantation, in the IL-17A KO group, less inflammation in the bronchovascular axis was observed and a non-significant trend towards less bronchovascular fibrosis, pleural/septal inflammation and fibrosis, and parenchymal inflammation and fibrosis when compared to WT mice

  4. Data show that IL-17 in the serum of collagen-induced arthritis (CIA (show NCOA5 Proteins)) mice was markedly increased on day 14 and reached its apogee on day 27.

  5. this study unveiled the role of IL-23 (show IL23A Proteins)-dependent IL-17 induction in LdCen-/- parasite-induced immunity and subsequent protection against visceral leishmaniasis

  6. There was a significantly decreased percentage of IL-17A-producing CD4 (show CD4 Proteins) T cells in mice receiving Tregs from xIAP (show XIAP Proteins) mice. xIAP (show XIAP Proteins) appears dispensable for the generation of induced Treg cells as well as function of natural Treg cells. There appeared to be a role of xIAP (show XIAP Proteins) in generation of IL-17-producing cells from either naive CD4 (show CD4 Proteins) T cells or Treg cells.

  7. astrocytic IL-17A plays important roles in the maintenance of neuropathic pain through CaMKII (show CAMK2G Proteins)/CREB (show CREB1 Proteins) signaling pathway in spinal cord.

  8. Results reveal the importance of the IL-23 (show IL23A Proteins)/IL-17 inflammatory axis in secondary brain injury after intracerebral hemorrhage.

  9. these results demonstrate an important role of CXCR6 (show CXCR6 Proteins) in the regulation of pathological Th17 and IL-17A(+)TCRgammadelta(+) T-cell recruitment into atherosclerotic lesions.

  10. These results suggest that IL-17A plays an important role in host survival against Toxoplasma gondii infection by protecting the host from an anaphylactic reaction via the downregulation of Toxoplasma gondii HSP70 (show HSP70 Proteins) and IFN-gamma (show IFNG Proteins) production.

Cow (Bovine) Interleukin 17A (IL17A) interaction partners

  1. calves, like humans, mount a robust IL-17 response during respiratory syncytial virus infection.

  2. Data show that CD4 (show CD4 Proteins)(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 termed Th17 and gammadelta17 cells.

  3. IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.

  4. IL-17A and IL-17F (show IL17F Proteins) have a potential to modulate the mammary gland immune response to mastitis-causing pathogens.

  5. The results of this study provide evidence of the role of IL-17 in the immunopathology of tuberculosis and support the use of IL-17 as a potential biomarker with predictive value of prognosis in bTB.

Pig (Porcine) Interleukin 17A (IL17A) interaction partners

  1. At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8 (show CD8A Proteins)+ T cell, gammadelta T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development.

  2. Alterations in the IL-17 regulated pathway of porcine colon in response to dietary supplementation with seaweeds and yeast are reported.

  3. conclude that only two subpopulations of porcine WBCs are sources of IL-17 after non-specific stimulation: CD3 (show CD3 Proteins)(+)CD4 (show CD4 Proteins)(+) and CD3 (show CD3 Proteins)(+)gammadeltaTCR(+).

  4. Cloning and expression of interleukin-17.

Rhesus Monkey Interleukin 17A (IL17A) interaction partners

  1. Data indicate that IL-17/22-producing cells play an important role in maintenance of intestinal mucosa in gluten-sensitive primates.

Guinea Pig Interleukin 17A (IL17A) interaction partners

  1. molecular cloning and expression of recombinant IL-17A; homology modeling revealed that the three-dimensional structure resembles that of human IL-17A. The secondary structure predicted showed the presence of one extra helix in the N-terminal region.

Rabbit Interleukin 17A (IL17A) interaction partners

  1. one of the interaction sites between IL17A and its receptor IL17RA (show IL17RA Proteins)

IL17A Protein Profile

Protein Summary

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Gene names and symbols associated with Interleukin 17A Proteins (IL17A)

  • interleukin 17A (IL17A)
  • interleukin 17A (Il17a)
  • ChIL-17 protein
  • CTLA-8 protein
  • Ctla8 protein
  • IL-17 protein
  • IL-17A protein
  • IL-17F protein
  • Il17 protein
  • IL17A protein

Protein level used designations for Interleukin 17A Proteins (IL17A)

CTLA-8 , cytotoxic T-lymphocyte-associated antigen 8 , cytotoxic T-lymphocyte-associated protein 8 , interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) , interleukin-17A , interleukin 17 , IL-17A , interleukin 17A , IL-17 , interleukin-17 , Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

3605 Homo sapiens
100034142 Equus caballus
16171 Mus musculus
282863 Bos taurus
395111 Gallus gallus
449530 Sus scrofa
472029 Pan troglodytes
481837 Canis lupus familiaris
708123 Macaca mulatta
301289 Rattus norvegicus
100735572 Cavia porcellus
100339322 Oryctolagus cuniculus
100860877 Capra hircus
101103931 Ovis aries
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