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IL29 encodes a cytokine distantly related to type I interferons and the IL-10 family.
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Human IL29 ELISA Kit for Sandwich ELISA - ABIN1672868
Srinivas, Dai, Eskdale, Gallagher, Megjugorac, Gallagher: Interferon-lambda1 (interleukin-29) preferentially down-regulates interleukin-13 over other T helper type 2 cytokine responses in vitro. in Immunology 2009
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In conclusion, IL-29 enhanced CXCL10 (show CXCL10 ELISA Kits) production in human oral epithelial cells via the p38 MAPK (show MAPK14 ELISA Kits), STAT3 (show STAT3 ELISA Kits), and NF-kappaB (show NFKB1 ELISA Kits) pathways, which might control Th1 (show TH1L ELISA Kits)-cell accumulation in periodontal lesions and be involved in pathological processes in periodontal disease.
The DNA binding domain of Ku70 was essential for formation of the Ku70-STING complex. Knocking down STING in primary human macrophages inhibited their ability to produce IFN-lambda1 in response to transfection with DNA or infection with the DNA virus HSV-2 (herpes simplex virus-2). Together, these data suggest that STING mediates the Ku70-mediated IFN-lambda1 innate immune response to exogenous DNA or DNA virus infection.
The review focuses on the value of the type I and III interferon (show IFNA ELISA Kits) subtypes (alphas, beta and lambdas) as therapeutics for prevention and treatment of viral infections (influenza, herpes, human immunodeficiency virus and hepatitis viruses).
Interferon (show IFNA ELISA Kits) lambda1/IL-29 and inorganic polyphosphate are novel regulators of neutrophil-driven thromboinflammation.
STAT2 (show STAT2 ELISA Kits) recruits USP18 (show USP18 ELISA Kits) to the type I IFN receptor subunit IFNAR2 (show IFNAR2 ELISA Kits) via its constitutive membrane-distal STAT2 (show STAT2 ELISA Kits)-binding site.
IL-29 stimulates inflammation and cartilage degradation by OA FLS, indicating that this cytokine is likely involved in the pathogenesis of OA.
IL-29 is a potential biomarker for disease activity in anti-cyclic citrullinated peptide-antibodies positive rheumatoid arthritis patients.
this study shows that serum levels of IL-29 play a role in the pathogenesis of Hashimoto's thyroiditis in Turkey
serum levels of IL-32 (show IL32 ELISA Kits) and TNF-alpha (show TNF ELISA Kits) may be diagnostic markers, and serum IL-29 levels may be associated with good prognosis in patients with gastric cancer
Serum levels of IL-29 and IFN-gamma (show IFNG ELISA Kits) are predictive of relapse outcomes after hepatitis C treatment.
We here report the molecular cloning, expression and antiviral activity of porcine IL-29
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
, cytokine Zcyto21
, interferon lambda-1
, interleukin 29 (interferon, lambda 1)
, interleukin 28B
, interferon lamda 1