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The protein encoded by IMPG2 binds chondroitin sulfate and hyaluronan and is a proteoglycan. Additionally we are shipping Interphotoreceptor Matrix Proteoglycan 2 Antibodies (8) and Interphotoreceptor Matrix Proteoglycan 2 Proteins (7) and many more products for this protein.
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IMPG1 and IMPG2 are new causal genes of vitelliform dystrophy, involved in 8% of our families.
Mutations in IMPG2 cause a severe form of retinitis pigmentosa with symptoms manifesting in the first 2 decades of life.
identification of IMPG2 mutations in autosomal-recessive retinitis pigmentosa; data show that mutations in a structural component of the interphotoreceptor matrix can cause autosomal-recessive retinitis pigmentosa
IPM 200 represents the second member of a novel family of retinal proteoglycans suspected to be involved in retinal adhesion and photoreceptor cell survival
May play an important role in photoreceptor development and maintenance.
The protein encoded by this gene binds chondroitin sulfate and hyaluronan and is a proteoglycan. The encoded protein plays a role in the organization of the interphotoreceptor matrix and may promote the growth and maintenance of the light-sensitive photoreceptor outer segment. Defects in this gene are a cause of retinitis pigmentosa type 56 and maculopathy, IMPG2-related.
interphotoreceptor matrix proteoglycan 2
, sialoprotein associated with cones and rods proteoglycan
, IPM 200
, interphotoreceptor matrix proteoglycan IPM 200
, interphotoreceptor matrix proteoglycan of 200 kDa