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Likely to be an important mediator of ventricular differentiation during cardiac development..
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We independently validated IRX4 as a potential prostate cancer risk gene through cis (show CISH Proteins)-expression quantitative trait loci analysis of prostate cancer risk variants.
the prostate cancer (PC)-susceptibility locus represented by rs12653946 at 5p15 is likely to regulate IRX4 expression in prostate which could suppress PC growth by interacting with the VDR pathway, conferring to PC susceptibility
IRX4 had a potential causative impact on the development of congenital heart disease, particularly ventricular septal defect.
Among migraineurs with aura (show AURKA Proteins) rs7698623 in MEPE (OR = 6.37; 95% CI 3.15-12.90; p = 2.7x10(-7)) and rs4975709 in IRX4 (OR = 5.06; 95% CI 2.66-9.62; p = 7.7x10(-7)) appeared to be associated with ischemic stroke.
Polymorphism A381>G of the Irx4 gene may have a modifier effect on septal thickness, resulting in increased corrected QT dispersion and higher outflow gradients.
IRX4+ cells in the cardiac crescent (show SFRP5 Proteins) represent the earliest cell population in the cellular hierarchy underlying ventricular myocardium development.
Likely to be an important mediator of ventricular differentiation during cardiac development.
iroquois homeobox protein 4
, Iroquois homeobox protein 4-A
, iroquois-4 homeobox transcription factor
, iroquois-class homeodomain protein irx-4-A
, homeodomain protein IRXA3
, iroquois-class homeodomain protein IRX-4
, Iroquois related homeobox 4