Jumonji Domain Containing 6 (JMJD6) ELISA Kits

JMJD6 encodes a nuclear protein with a JmjC domain. Additionally we are shipping Jumonji Domain Containing 6 Antibodies (123) and Jumonji Domain Containing 6 Proteins (13) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
JMJD6 360665 Q6AYK2
JMJD6 23210 Q6NYC1
JMJD6 107817 Q9ERI5
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More ELISA Kits for Jumonji Domain Containing 6 Interaction Partners

Human Jumonji Domain Containing 6 (JMJD6) interaction partners

  1. JMJD6 is a novel Stress Granule component that interacts with G3BP1 (show G3BP1 ELISA Kits) complexes, and its expression reduces G3BP1 (show G3BP1 ELISA Kits) monomethylation and asymmetric dimethylation at three Arg residues.

  2. JMJD6 regulates VHL gene expression in the human placenta. VHL downregulation in preeclampsia is dependent on decreased JMJD6 demethylase activity due to hypoxia and reduced Fe2+ bioavailability.

  3. In tumor samples but not normal breast tissue, the expression of JMJD6 linearly correlated with HOTAIR suggesting that JMJD6-mediated up-regulation may occur specifically in tumors.

  4. Results show that JMJD6 is up-regulated in melanoma, and high expression of JMJD6 protein is strongly correlated with advanced stages and aggressiveness of melanoma. It enhances the MAPK (show MAPK1 ELISA Kits) signaling through regulation of alternative splicing of PAK1 (show PAK1 ELISA Kits) promoting multiple cellular processes including melanogenesis, proliferation, invasion, and angiogenesis in melanoma cells.

  5. High JMJD6 expression is associated with Neuroblastomas.

  6. miR (show MLXIP ELISA Kits)-770 acted on a tumor suppressor by binding to the 3'UTR (show UTS2R ELISA Kits) of JMJD6 and downregulated its expression in NSCLC cells; this study also demonstrated that JMJD6 played as an oncogene (show RAB1A ELISA Kits) in NSCLC cells

  7. JMJD6 regulated a large set of alternative splicing events, and importantly, its regulated splicing events were significantly overlapped those controlled by U2AF65.

  8. AcK27-HOXB9 (show HOXB9 ELISA Kits) suppresses the transcription of its target gene Jumonji domain-containing protein 6 (JMJD6) by direct occupying the promoter of JMJD6 gene.

  9. These findings provide evidence that JMJD6 may play a role in regulating the production of sFLT-1 in the preeclamptic placenta. Decreased placental JMJD6 expression may be an important component to the pathophysiology of preeclampsia.

  10. Study identified a novel epigenetic mechanism showing how JMJD6 cooperates with Myc (show MYC ELISA Kits) during oncogenic transformation. Combined high expression of Myc (show MYC ELISA Kits) and JMJD6 confers a more aggressive phenotype in mouse and human tumors.

Zebrafish Jumonji Domain Containing 6 (JMJD6) interaction partners

  1. results suggest that YY1a (show YY1 ELISA Kits) regulates PS receptor expression that linked to function of PSR-phagocyte mediated apoptotic cell engulfment during development

  2. PSR-dependent system in zebrafish embryos that engulfs apoptotic cells mediated by PSR-phagocytes during development, with the system assuming an important role in the normal development of tissues such as the brain, heart, notochord and somite

Mouse (Murine) Jumonji Domain Containing 6 (JMJD6) interaction partners

  1. TEC-specific deletion of Jmjd6 exacerbates development of autoimmune diabetes in a mouse model, which express both ovalbumin (OVA) under the control of the rat insulin gene promoter and OT-I T cell receptor specific for OVA peptide bound to major histocompatibility complex class I K(b) molecules.

  2. Although Jmjd6 deficiency does not affect abundance of Aire (show AIRE ELISA Kits) transcript, the intron 2 of Aire (show AIRE ELISA Kits) gene is not effectively spliced out in the absence of Jmjd6, resulting in reduction of mature Aire (show AIRE ELISA Kits) protein and spontaneous multi-organ autoimmunity in mice.

  3. The results indicate dual roles for JMJD6 in promoting adipogenic gene expression program by post-transcriptional regulation of C/EBPbeta (show CEBPB ELISA Kits) and C/EBPdelta (show CEBPD ELISA Kits) and direct transcriptional activation of Ppargamma2 (show PPARG ELISA Kits) and Cebpalpha during adipocyte differentiation.

  4. histones are additional substrates of JMJD6 in vivo. Because 5-hydroxylation of lysyl residues inhibited N-acetylation and N-methylation by an acetyltransferase and a methyltransferase

  5. confirmed that Jmjd6 forms multimers and showed that nuclear localization of the protein involves association with a nucleic acid matrix

  6. protein kinase C beta (show PRKCB ELISA Kits) activation is dependent upon phosphatidylserine receptor action

  7. data demonstrate a critical role for PSR in early stages of mammalian organogenesis and suggest that this receptor may be involved in respiratory distress syndromes and congenital brain malformations

  8. during embryonic development, phosphatidylserine receptor-mediated apoptotic cell uptake is required for definitive erythropoiesis and T lymphopoiesis, independently of the prevention of inflammatory responses

  9. Ptdsr is localized in the cell nucleus via multiple nuclear localization signals.

  10. Ptdsr is essential for the development and differentiation of multiple organs during embryogenesis but not for apoptotic cell clearance.

Cow (Bovine) Jumonji Domain Containing 6 (JMJD6) interaction partners

  1. JMJD6 contributes to foot-and-mouth disease virus infectivity and may be a previously unidentified foot-and-mouth disease receptor.

  2. Demethylated RHA bound JMJD6 monomer during foot-and-mouth disease virus infection.

Jumonji Domain Containing 6 (JMJD6) Antigen Profile

Antigen Summary

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells\; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with JMJD6

  • arginine demethylase and lysine hydroxylase (Jmjd6) antibody
  • arginine demethylase and lysine hydroxylase (JMJD6) antibody
  • jumonji domain containing 6 (jmjd6) antibody
  • jumonji domain containing 6 (Jmjd6) antibody
  • bifunctional arginine demethylase and lysyl-hydroxylase PSR (LOC411069) antibody
  • jumonji domain containing 6 (JMJD6) antibody
  • jmjC domain-containing protein 4 homolog (LOC5577546) antibody
  • phosphatidylserine receptor (CpipJ_CPIJ004848) antibody
  • phosphatidylserine receptor (CpipJ_CPIJ019866) antibody
  • jumonji domain containing 6 S homeolog (jmjd6.S) antibody
  • jumonji domain containing 6 L homeolog (jmjd6.L) antibody
  • 5730436I23Rik antibody
  • cg5383 antibody
  • D11Ertd195e antibody
  • GB15204 antibody
  • jmjd6 antibody
  • mKIAA0585 antibody
  • psr antibody
  • PtdSerR antibody
  • ptdsr antibody
  • ptdsr1 antibody
  • zfpsr antibody
  • zgc:66264 antibody

Protein level used designations for JMJD6

bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 , histone arginine demethylase JMJD6 , jmjC domain-containing protein 6 , jumonji domain-containing protein 6 , lysyl-hydroxylase JMJD6 , peptide-lysine 5-dioxygenase JMJD6 , phosphatidylserine receptor , jumonji domain containing 6 , apoptotic cell clearance receptor PtdSerR , protein PTDSR , Histone arginine demethylase JMJD6 , bifunctional arginine demethylase and lysyl-hydroxylase JMJD6-B , histone arginine demethylase JMJD6-B , jmjC domain-containing protein 6-B , jumonji domain-containing protein 6-B , lysyl-hydroxylase JMJD6-B , peptide-lysine 5-dioxygenase JMJD6-B , phosphatidylserine receptor-B , protein PTDSR-B , bifunctional arginine demethylase and lysyl-hydroxylase JMJD6-A , histone arginine demethylase JMJD6-A , jmjC domain-containing protein 6-A , jumonji domain-containing protein 6-A , lysyl-hydroxylase JMJD6-A , peptide-lysine 5-dioxygenase JMJD6-A , phosphatidylserine receptor-A , protein PTDSR-A

360665 Rattus norvegicus
23210 Homo sapiens
266962 Danio rerio
100230335 Taeniopygia guttata
107817 Mus musculus
411069 Apis mellifera
417355 Gallus gallus
508343 Bos taurus
5577546 Aedes aegypti
6036446 Culex quinquefasciatus
6054124 Culex quinquefasciatus
468338 Pan troglodytes
548957 Xenopus (Silurana) tropicalis
100173544 Pongo abelii
380206 Xenopus laevis
444377 Xenopus laevis
483335 Canis lupus familiaris
100722696 Cavia porcellus
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