K(lysine) Acetyltransferase 8 (KAT8) ELISA Kits

KAT8 encodes a member of the MYST histone acetylase protein family. Additionally we are shipping K(lysine) Acetyltransferase 8 Antibodies (71) and K(lysine) Acetyltransferase 8 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
KAT8 310194 Q5XI06
KAT8 84148 Q9H7Z6
KAT8 67773 Q9D1P2
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Top K(lysine) Acetyltransferase 8 ELISA Kits at antibodies-online.com

Showing 3 out of 9 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.11 ng/mL 0.312-20 ng/mL   96 Tests 2 to 3 Days
$713.90
Details
Mouse
  96 Tests 11 to 18 Days
$618.29
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Rat
  96 Tests 11 to 18 Days
$618.29
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More ELISA Kits for K(lysine) Acetyltransferase 8 Interaction Partners

Human K(lysine) Acetyltransferase 8 (KAT8) interaction partners

  1. a novel function for the MYST KATs as lysine propionyltransferases

  2. Novel importin alpha1-specific nuclear localization signals were identified in the N-terminal of MOF.

  3. Data describe a trans-histone modification pathway involving PKN1/histone H3 threonine 11 phosphorylation followed by WDR5/MLL histone methyltransferase and KAT8/histone acetyltransferase recruitment to effect androgen-dependent gene activation and prostate cancer cell proliferation.

  4. These findings provide insight into the regulation of LSD1 and Epithelial-to-Mesenchymal Transition (EMT) and identify MOF as a critical suppressor of EMT and tumor progression.

  5. This work identifies MOF as a key regulator of cellular stress response in glomerular podocytes.

  6. recent results indicate MOF is an upstream regulator of the ATM (ataxia-telangiectasia mutated) protein, the loss of which is responsible for ataxia telangiectasia (AT). ATM is a key regulatory kinase that interacts with and phosphorylates multiple substrates that influence critical, cell-cycle control and DNA damage repair pathways in addition to other pathways.

  7. Histone acetyltransferase activity of MOF is required to sustain MLL-AF9 leukemia and may be important for multiple AML subtypes.

  8. our findings reveal that TET1 forms a complex with hMOF to modulate its function and the level of H4K16Ac ultimately affect gene expression and DNA repair.

  9. these studies point to the critical and specific role of hMOF Lys-274 autoacetylation in hMOF stability and cognate substrate acetylation and argues that binding of Ac-CoA to hMOF likely drives Lys-274 autoacetylation for subsequent cognate substrate acetylation.

  10. MOF is a dual-transcriptional regulator of nuclear and mitochondrial genomes connecting epigenetics and metabolism.

  11. MOF is highly enriched in induced pluripotent stem cells (iPSCs), and MOF expression is upregulated during the reprogramming process. The ectopic expression of MOF promotes reprogramming. MOF affects Wdr5 and endogenous Oct4 expression.

  12. Along with the PHF20/MOF complex, G9a links the crosstalk between ERalpha methylation and histone acetylation that governs the epigenetic regulation of hormonal gene expression.

  13. Data found downregulation of hMOF in gastric cancer cells and tissues. Declined hMOF expression, but not high level of HDAC4, may account for global histone H4K16ac suggesting that loss of hMOF expression may be involved in gastric cancer progression.

  14. EZH2 (enhancer of zeste homolog 2) was up-regulated in human oral tongue squamous cell carcinoma tissues and its level positively correlated with level of hMOF.

  15. Mutant MOF-T392A expression abrogates DSB repair in S/G2 phase cells. MOF-T392A has delayed 53BP1 dissociation and decreased DNA association.

  16. Results show the expression of hMOF mRNA and protein was significantly downregulated in ovarian epithelial cancer tissues, and patients with high hMOF levels showed improved survival as compared to those with low hMOF levels.

  17. The histone acetyltransferase hMOF suppresses hepatocellular carcinoma growth by targeting the expression of SIRT6.

  18. Functional interactions of MYST1 with androgen receptor and NF-KB are critical for prostate cancer progression.

  19. hMOF was overexpressed in human non-small cell lung cancer and was a predictor of poor survival.

  20. low expression of hMOF was strongly correlated with tumor differentiation and survival of patients with gastric cancer. While in patients with renal cell carcinoma, downregulation of hMOF was connected to ccRCC and tissues with T1 tumor status.

Mouse (Murine) K(lysine) Acetyltransferase 8 (KAT8) interaction partners

  1. Study utilizing Mof knockout mice demonstrate that MLL4 co-localizes with H4K16ac in vivo and that the association of MLL4 with a set of genomic targets is Mof dependent and requires the acetyltransferase activity of Mof.

  2. MOF regulates male meiosis and is involved in the expansion of all three waves of H2AX phosphorylation from the leptotene to pachytene stages, initiated by ATM and ATR, respectively.

  3. study demonstrated that HAT Mof is involved in the development of colitis, and the lack of Mof ameliorates DSS-induced colitis in mice.

  4. This work identifies MOF as a key regulator of cellular stress response in glomerular podocytes.

  5. demonstrate that KAT8 is essential for female fertility by regulating antioxidant gene expression and identify KAT8 as the first histone acetyltransferase with an essential function in oogenesis

  6. MOF is a developmental-stage-specific chromatin regulator found to be essential for adult but not early fetal hematopoiesis.

  7. MOF is a dual-transcriptional regulator of nuclear and mitochondrial genomes connecting epigenetics and metabolism.

  8. STAT5B and MOF work as negative regulators in adipogenesis.

  9. complex provides additional, Tsix-independent repression of Xist by maintaining pluripotency

  10. NSL and MSL HAT complexes differentially regulate specific sets of expressed genes in mESCs and during differentiation

  11. cardiac-specific MOF overexpression protected mice from transverse aortic constriction-induced cardiac hypertrophy, with reduced radios of heart weight/body weight, decreased left ventricular wall thickness and increased fractional shortening.

  12. Mof plays a critical role in T-cell differentiation and that depletion of Mof in T cells reduces T-cell numbers and, by an undefined mechanism, induces genomic instability in B cells through bystander mechanism.

  13. Depletion of MOF in mouse embryonic stem cells causes a specific decrease in expression of a subset of X-linked genes.

  14. the histone acetyltransferase Mof plays an essential role in the maintenance of ESC self-renewal and pluripotency

  15. PHF20 is not required for maintaining the global H4K16 acetylation levels or locus specific histone acetylation but instead works downstream in transcriptional regulation of MOF target genes

  16. Purkinje cells (PC)-specific deletion of the mouse males absent on the first (mMof) gene (Cre(-)), which encodes a protein that specifically acetylates histone H4 at lysine 16 (H4K16ac) and influences ATM function, is critical for PC longevity.

  17. Msl1 interacts with Msl3 as an extended chain forming an extensive hydrophobic interface, whereas the Msl1-MOF interface involves electrostatic interactions between the HAT domain and a long helix of Msl1.

  18. Data show that loss of Mof leads to reduction of histone H4 K16 acetylation, cell cycle arrest, chromosome aberration, defects in DNA damage repair, and complete loss of Mdc1 response to DNA damage.

  19. MOF is an essential factor for embryogenesis and oncogenesis

  20. Mof is required specifically for the maintenance of histone4 lysine16 acetylation and normal chromatin architecture of all cells of early male and female embryos.

K(lysine) Acetyltransferase 8 (KAT8) Antigen Profile

Antigen Summary

This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KAT8

  • K(lysine) acetyltransferase 8 (kat8) antibody
  • lysine acetyltransferase 8 (KAT8) antibody
  • lysine acetyltransferase 8 (Kat8) antibody
  • K(lysine) acetyltransferase 8 (Kat8) antibody
  • 2010203C02Rik antibody
  • 5830450F21Rik antibody
  • D7Ertd629e antibody
  • hMOF antibody
  • MOF antibody
  • MYST1 antibody
  • wu:fb22g02 antibody
  • wu:fj22d09 antibody
  • ZC2HC8 antibody
  • zgc:66387 antibody

Protein level used designations for KAT8

MYST histone acetyltransferase 1 , histone acetyltransferase KAT8 , K(lysine) acetyltransferase 8 , probable histone acetyltransferase MYST1-like , MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 , MYST protein 1 , MYST-1 , lysine acetyltransferase 8 , probable histone acetyltransferase MYST1 , histone acetyltransferase MYST1 , ortholog of Drosophila males absent on the first (MOF) , histone acetyltransferase Myst1

GENE ID SPECIES
548988 Xenopus (Silurana) tropicalis
100003790 Danio rerio
100019305 Monodelphis domestica
100064910 Equus caballus
100341732 Oryctolagus cuniculus
100387289 Callithrix jacchus
100435717 Pongo abelii
100522367 Sus scrofa
100593658 Nomascus leucogenys
310194 Rattus norvegicus
84148 Homo sapiens
67773 Mus musculus
479777 Canis lupus familiaris
100125883 Bos taurus
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