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KAT8 encodes a member of the MYST histone acetylase protein family.
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Data describe a trans-histone modification pathway involving PKN1 (show PKN1 ELISA Kits)/histone H3 (show HIST3H3 ELISA Kits) threonine 11 phosphorylation followed by WDR5/MLL histone methyltransferase and KAT8/histone acetyltransferase (show HAT ELISA Kits) recruitment to effect androgen-dependent gene activation and prostate cancer cell proliferation.
These findings provide insight into the regulation of LSD1 (show KDM1A ELISA Kits) and Epithelial-to-Mesenchymal Transition (EMT (show ITK ELISA Kits)) and identify MOF as a critical suppressor of EMT (show ITK ELISA Kits) and tumor progression.
This work identifies MOF as a key regulator of cellular stress response in glomerular podocytes.
recent results indicate MOF is an upstream regulator of the ATM (ataxia-telangiectasia mutated (show ATM ELISA Kits)) protein, the loss of which is responsible for ataxia telangiectasia (AT). ATM (show ATM ELISA Kits) is a key regulatory kinase that interacts with and phosphorylates multiple substrates that influence critical, cell-cycle control and DNA damage repair pathways in addition to other pathways.
Histone acetyltransferase (show HAT ELISA Kits) activity of MOF is required to sustain MLL-AF9 leukemia and may be important for multiple AML (show RUNX1 ELISA Kits) subtypes.
our findings reveal that TET1 forms a complex with hMOF to modulate its function and the level of H4K16Ac ultimately affect gene expression and DNA repair.
these studies point to the critical and specific role of hMOF Lys (show LYZ ELISA Kits)-274 autoacetylation in hMOF stability and cognate substrate acetylation and argues that binding of Ac-CoA to hMOF likely drives Lys (show LYZ ELISA Kits)-274 autoacetylation for subsequent cognate substrate acetylation.
MOF is a dual-transcriptional regulator of nuclear and mitochondrial genomes connecting epigenetics and metabolism.
MOF is highly enriched in induced pluripotent stem cells (iPSCs), and MOF expression is upregulated during the reprogramming process. The ectopic expression of MOF promotes reprogramming. MOF affects Wdr5 and endogenous Oct4 (show POU5F1 ELISA Kits) expression.
Along with the PHF20/MOF complex, G9a (show EHMT2 ELISA Kits) links the crosstalk between ERalpha (show ESR1 ELISA Kits) methylation and histone acetylation that governs the epigenetic regulation of hormonal gene expression.
demonstrate that KAT8 is essential for female fertility by regulating antioxidant gene expression and identify KAT8 as the first histone acetyltransferase (show HAT ELISA Kits) with an essential function in oogenesis
MOF is a developmental-stage-specific chromatin regulator found to be essential for adult but not early fetal hematopoiesis.
STAT5B (show STAT5B ELISA Kits) and MOF work as negative regulators in adipogenesis.
NSL and MSL HAT (show HAT ELISA Kits) complexes differentially regulate specific sets of expressed genes in mESCs and during differentiation
cardiac-specific MOF overexpression protected mice from transverse aortic constriction-induced cardiac hypertrophy, with reduced radios of heart weight/body weight, decreased left ventricular wall thickness and increased fractional shortening.
Mof plays a critical role in T-cell differentiation and that depletion of Mof in T cells reduces T-cell numbers and, by an undefined mechanism, induces genomic instability in B cells through bystander mechanism.
Depletion of MOF in mouse embryonic stem cells causes a specific decrease in expression of a subset of X-linked genes.
the histone acetyltransferase Mof plays an essential role in the maintenance of ESC self-renewal and pluripotency
This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene.
MYST histone acetyltransferase 1
, histone acetyltransferase KAT8
, K(lysine) acetyltransferase 8
, probable histone acetyltransferase MYST1-like
, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1
, MYST protein 1
, lysine acetyltransferase 8
, probable histone acetyltransferase MYST1
, histone acetyltransferase MYST1
, ortholog of Drosophila males absent on the first (MOF)
, histone acetyltransferase Myst1