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TVAG_247310 encodes a member of the keratin family, the most diverse group of intermediate filaments.
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PADI4 (show PADI4 Antibodies) contributes to gastric tumorigenesis by upregulating CXCR2 (show CXCR2 Antibodies), KRT14 (show KRT14 Antibodies) and TNF-alpha (show TNF Antibodies) expression.
this study adds a further 10 novel mutations to the catalogued genotype-phenotype correlations in epidermolysis bullosa simplex and demonstrates a potential modifying effect of SNPs on the phenotype. We therefore support the notion of full DNA sequencing of both KRT5 (show KRT5 Antibodies) and KRT14 (show KRT14 Antibodies) genes so as to not miss any variants in the genes contributing to the phenotype.
The novel c.1234A>G(p.Ile412Val) mutation of the KRT14 (show KRT14 Antibodies) gene is probably responsible for the disease.
Keratin14/p63 (show RPE65 Antibodies)-positive epithelial proliferations suggest benign breast disease.
K14 (show KRT14 Antibodies) was coexpressed with alphav-integrin (show ITGAV Antibodies) in fetal and adult corneas and cultured corneolimbal epithelium, and colony-forming efficiency (an indicator of stem cell activity) was similar in cells from both sources.
Loss of keratin 14 (show KRT14 Antibodies) is associated with epidermolysis bullosa.
vimentin (show VIM Antibodies) regulates the differentiation switch via modulation of K5/K14 (show KRT14 Antibodies) expression. Moreover, because there was a significant correlation between high vimentin (show VIM Antibodies)-K14 (show KRT14 Antibodies) expression and recurrence/poor survival in oral cancer patients, vimentin (show VIM Antibodies)-K14 (show KRT14 Antibodies) together may prove to be the novel markers for the prognostication of human oral cancer.
We concluded that smoking habits were capable of inducing changes in global DNA methylation (show HELLS Antibodies), miR (show MLXIP Antibodies)-9-3 methylation status and K19 (show KRT19 Antibodies) expression.
data demonstrates that keratinocyte migration requires the interaction between vimentin (show VIM Antibodies) and keratins at the -YRKLLEGEE- sequence at the helical 2B domain of viment
Immunocytochemistry using this antibody cocktail comprises five antibodies recognising p63 (show RPE65 Antibodies), and cytokeratins ( 7, 18, 5 and 14) showed good sensitivity and specificity for diagnosing breast cancers. Thus, this method is useful for mammary cytology using FNA
RA regulates Krt5 (show KRT5 Antibodies) and Krt14 (show KRT14 Antibodies) expression independently of stem cell character in developing salivary epithelium. The stem cell gene Kit is regulated inversely from Krt5 (show KRT5 Antibodies)/Krt14 (show KRT14 Antibodies) by RA signaling.
Analysis of K14 variants with single or multiple substitutions of cysteine residues points to a spatial and temporal hierarchy in how Cys-4/Cys-40 and Cys-367 regulate keratin assembly in vitro and filament dynamics in live keratinocytes
Disulfide bonding is a novel and important mechanism regulating the assembly, intracellular organization, and dynamics of K14 (show KRT14 Antibodies)-containing intermediate filaments in skin keratinocytes.
K14-VEGF transgenic mouse a valuable model to study novel immunotherapies for psoriasis
autoantibodies in Scurfy (show FOXP3 Antibodies) mice and patients with IPEX (show FOXP3 Antibodies) target keratin 14 (show KRT14 Antibodies)
nipple connective tissue and its development: insights from the keratin 14 (show KRT14 Antibodies)-PTHrP (show PTHLH Antibodies) mouse
The keratin-14 (show KRT14 Antibodies) IL-4 (show IL4 Antibodies) transgenic (Tg) mouse model of atopic dermatitis (AD) is characterized by skin infiltration of T cells, early up-regulation of T(h)2 cytokines and late surge of T(h)1 cytokines.
These studies provide a potential mechanism by which deltaNp63 directly governs the expression of K14 (show KRT14 Antibodies) in a keratinocyte-specific manner.
Study describes the expression profile of claudins and keratin markers in the accelerated epidermal permeability barrier formation of K14 (show KRT14 Antibodies)-CaSR (show CASR Antibodies) transgenic mice during development as compared to the wild type from E12.5 to newborn stages.
IL-6 (show IL6 Antibodies) and IFN-gamma (show IFNG Antibodies) stimulated VEGF-A (show VEGFA Antibodies) mRNA production in the skin and in primary keratinocytes of keratin 14 (show KRT14 Antibodies) IL-4 (show IL4 Antibodies) transgenic mice
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11.
, cytokeratin 14
, keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)
, keratin, type I cytoskeletal 14
, epidermolysis bullosa simplex, Dowling-Meara, Koebner
, keratin complex 1, acidic, gene 14
, type I keratin Ka14