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KRT17 encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages.
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Human KRT17 ELISA Kit for Sandwich ELISA - ABIN366279
Liu, Wu, Cao, Xu, Gao, Chen, Geng: Shikonin inhibits IFN-?-induced K17 over-expression of HaCaT cells by interfering with STAT3 signaling. in International journal of clinical and experimental pathology 2015
Our results highlight KRT17 as a possible biomarker in gastric cancer promoting tumor growth, motility, and invasion, and suggest that KRT17 can be a valuable molecular target for development of anti-gastric cancer-specific therapies
The findings suggest that CK17, although not specific for differentiated vulvar intraepithelial neoplasia (dVIN), when combined with histologic findings, Ki-67 (show MKI67 ELISA Kits), and p53 (show TP53 ELISA Kits) immunohistochemistry, can be a marker of vulvar dysplasia and serve as an adjunct in the diagnosis of dVIN.
Krt17 was demonstrated to contribute to areca nut-induced oral malignancy
TGFbeta (show TGFB1 ELISA Kits)/SMAD (show SMAD1 ELISA Kits)/miR (show MLXIP ELISA Kits)-486-3p signaling axis in keratinocytes regulated K17 expression and cell proliferation. We conclude that the loss of miR (show MLXIP ELISA Kits)-486-3p in psoriatic epidermis leads to K17 protein overexpression and contributes to the pathogenesis of psoriasis.
inflammatory cytokines promoted Nrf2 (show GABPA ELISA Kits) nuclear translocation in psoriatic epidermis, which led to elevated expression of K6, K16 (show KRT16 ELISA Kits), and K17, thus promoting keratinocyte proliferation and contributing to the pathogenesis of psoriasis.
KRT17 promotes tumor cell growth, at least partially, through its anti-apoptotic effect as a result of the KRT17 overexpression by GLIs in oral squamous cell carcinoma (OSCC)..
TGF-beta1-induced CK17 enhances cancer stem cell-like properties rather than epithelial-mesenchymal transition in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway.
K17 is highly expressed in most cases of both invasive adenocarcinoma and in AIS (show AR ELISA Kits) and is a powerful, negative prognostic marker for patient survival.
the data suggest that the loss of Krt17 may foster an overall protective environment for lesion-prone cervical tissue.
K17 is expressed in a subset of triple-negative breast cancers, and is a marker of poor prognosis in patients with advanced stage and ER(-)/HER2 (show ERBB2 ELISA Kits)(-) breast cancer.
p53 (show TP53 ELISA Kits) operates as a direct Krt17 repressor that invites therapeutic targeting in radiodermatitis .
genetic loss of caspase-7 (show CASP7 ELISA Kits) promotes solar-simulated light-induced skin carcinogenesis by blocking caspase-7 (show CASP7 ELISA Kits)-mediated cleavage of keratin-17.
Data indicate that keratin 17 (k17) regulates autoimmune regulator Aire (show AIRE ELISA Kits) to promote skin tumorigenesis.
These findings functionally integrate K17, hnRNP K (show HNRNPK ELISA Kits), and gene expression along with RSK (show RPS6KA1 ELISA Kits) and CXCR3 (show CXCR3 ELISA Kits) signaling in a keratinocyte-autonomous axis and provide a potential basis for their implication in tumorigenesis
KRT17 is necessary for oncogenic transformation in Ewing sarcoma and accounts for much of the GLI1 (show GLI1 ELISA Kits)-mediated transformation function but via a mechanism independent of AKT (show AKT1 ELISA Kits) signaling.
Cytochrome b5 (show CYB5A ELISA Kits) and cytokeratin 17 are biomarkers in bronchoalveolar fluid signifying onset of acute lung injury.
IL-22 (show IL22 ELISA Kits) up-regulates K17 expression in keratinocytes in a dose-dependent manner through STAT3 (show STAT3 ELISA Kits)- and ERK1/2 (show MAPK1/3 ELISA Kits)-dependent mechanisms.
Type I keratin (show KRT12 ELISA Kits) 17 protein is phosphorylated on serine 44 by p90 (show GPAM ELISA Kits) ribosomal protein S6 kinase 1 (RSK1 (show RPS6KA1 ELISA Kits)) in a growth- and stress-dependent fashion
This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.
, keratin 17 epitope S1
, keratin 17 epitope S2
, keratin 17 epitope S4
, keratin, type I cytoskeletal 17
, type I keratin KA17
, keratin complex 1, acidic, gene 17
, keratin 17
, keratin 16
, Keratin, type I cytoskeletal 17