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KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009].. Additionally we are shipping Killer Cell Lectin-Like Receptor Subfamily F, Member 1 Proteins (5) and Killer Cell Lectin-Like Receptor Subfamily F, Member 1 Kits (2) and many more products for this protein.
Showing 10 out of 52 products:
Human Monoclonal KLRF1 Primary Antibody for FACS - ABIN4897741
Le Garff-Tavernier, Decocq, de Romeuf, Parizot, Dutertre, Chapiro, Davi, Debré, Prost, Teillaud, Merle-Beral, Vieillard: Analysis of CD16+CD56dim NK cells from CLL patients: evidence supporting a therapeutic strategy with optimized anti-CD20 monoclonal antibodies. in Leukemia 2011
Show all 4 Pubmed References
Human Monoclonal KLRF1 Primary Antibody for CyTOF, FACS - ABIN4900459
Beziat, Nguyen, Lapusan, Hervier, Dhedin, Bories, Uzunov, Boudifa, Trebeden-Negre, Norol, Marjanovic, Marie, Vernant, Debre, Rio, Vieillard: Fully functional NK cells after unrelated cord blood transplantation. in Leukemia 2009
Show all 2 Pubmed References
Human Polyclonal KLRF1 Primary Antibody for FACS, WB - ABIN4900514
Bauer, Wotapek, Zöller, Rutkowski, Steinle: The Activating C-type Lectin-like Receptor NKp65 Signals through a Hemi-immunoreceptor Tyrosine-based Activation Motif (hemITAM) and Spleen Tyrosine Kinase (Syk). in The Journal of biological chemistry 2017
NKp80 is a marker of natural killer (NK) cell maturity in secondary lymphoid tissues and supports NK cell development through a stage 4a intermediate with ILC3-associated features.
In the second trimester, functional markers of Decidual natural killer activation, i.e., angiogenic factor (show VEGFA Antibodies) production (e.g., vascular endothelial growth factor (show VEGF Antibodies), interleukin-8 (show IL8 Antibodies), interferon-gamma (show IFNG Antibodies)), remained stable despite an increase in NKp80 or NKG2D (show KLRK1 Antibodies) surface expression.
IL-15 (show IL15 Antibodies)+IL-12 (show IL12A Antibodies) has an immunomodulatory effect on NK cell subsets from HIV-infected individuals viz down-regulation of iNKRs, elevation of activatory receptors NKp46 (show NCR1 Antibodies) and NKG2D (show KLRK1 Antibodies), and induction of coreceptor NKp80.
our data report a previously unrecognized regulatory circuit enabling autonomous control of human NK cell responses via the NKp80-AICL (show CLEC2B Antibodies) axis.
Two non-consensus amino acids of NKp80, in particular arginine 6, critically impair both hemi-immunoreceptor tyrosine-based activation motif phosphorylation and Syk (show SYK Antibodies) recruitment.
Activating receptor NKp80 induces cytotoxicity by using an atypical hemi-ITAM amino acid seqeuence and the Syk (show SYK Antibodies)-kinase pathway.
NKp80 is expressed on a highly responsive subset of effector memory CD8 (show CD8A Antibodies) T cells with an inflammatory NK-like phenotype and promotes T-cell responses toward AICL (show CLEC2B Antibodies)-expressing cells.
phenotypic, molecular, and functional characterization for triggering molecules (NKp46 (show NCR1 Antibodies), NKp30 (show NCR3 Antibodies) NKp80, and NKG2D (show KLRK1 Antibodies); in this AIDS-resistant species, relevant differences to human NK cells involve NKp80 and particularly NKp30 (show NCR3 Antibodies)
KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009
C-type lectin domain family 5 member C
, activating coreceptor NKp80
, killer cell lectin-like receptor F1
, killer cell lectin-like receptor subfamily F member 1
, lectin-like receptor F1
, killer cell lectin-like receptor subfamily F, member 1
, NKp80 receptor
, Activating coreceptor NKp80
, Lectin-like receptor F1
, NKp80 NK receptor