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Kinesin is a molecular motor that generates ATP-dependent movement of vesicles and organelles along microtubules. Additionally we are shipping KLC2 Antibodies (61) and many more products for this protein.
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a homozygous 216-bp deletion located at the non-coding upstream region of the KLC2 gene in patients with SPOAN syndrome causes overexpression of the gene
Results identified KLC2 as a novel target and of miR (show MLXIP Proteins)-125b in non-small-cell lung cancer (NSCLC) and show the oncogenic potential of KLC2 in the progression of NSCLC.
For the binding of cargos shared by KLC2, we propose a different site located within the groove but not involving N343.
Na,K-ATPase (show ATP1A1 Proteins) traffic toward the plasma membrane in alveolar epithelial cells is driven by kinesin-1, where KLC2 is the isoform regulating this process.
structural plasticity of the N-terminal capping helix might represent a structural determinant for TPR domain structural versatility in cargo binding
KLC2 is a cellular target of GSK-3beta capable of regulating synaptic plasticity, particularly AMPA (show GRIA3 Proteins) receptor trafficking, as well as mood-associated behaviors in animal models
Kinesin is a molecular motor that generates ATP-dependent movement of vesicles and organelles along microtubules. Kinesin consists of 2 light chains, such as KLC2, and 2 heavy chains (see KIF5B\; MIM 602809) in a 1:1 stoichiometric ratio (Rahman et al., 1998
kinesin light chain 2
, KLC 2