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Transcription repressor that binds to the promoter of target genes and prevents their expression. Additionally we are shipping KLF17 Kits (12) and KLF17 Proteins (3) and many more products for this protein.
Showing 10 out of 63 products:
Human Polyclonal KLF17 Primary Antibody for FACS, WB - ABIN651698
Gumireddy, Li, Gimotty, Klein-Szanto, Showe, Katsaros, Coukos, Zhang, Huang: KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. in Nature cell biology 2009
Show all 2 Pubmed References
Human Polyclonal KLF17 Primary Antibody for ICC, IF - ABIN4329120
Blakeley, Fogarty, del Valle, Wamaitha, Hu, Elder, Snell, Christie, Robson, Niakan: Defining the three cell lineages of the human blastocyst by single-cell RNA-seq. in Development (Cambridge, England) 2015
Data suggest that Neptune is a new member of hatching gland specifier and plays a physiological role in determination and specification of multiple lineages derived from the NPB region.
Expression in prospective ventral cells may be involved in the activation of the process of tail formation.
Low Expressions of KLF17 is associated with lung adenocarcinoma.
Suggest that KLF17 inhibits esophageal carcinoma development and may serve as a potential therapeutic target.
Enhanced KLF17 expression sensitizes ERalpha-positive breast cancer cells to endocrine therapy.KLF17-ERalpha interaction plays a potential role in inhibition of ERalpha-dependent breast cancer progression.
KLF17 empowers TGF-beta/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression.
Tumor-suppressive p53 signaling is critical for KLF17 to inhibit cancer metastasis in Non-small Cell Lung Cancer.
A small subset of Myoepithelial tumors harbor FUS rearrangements, two thirds of them being associated with KLF17 fusion.
In this review, we focus on the functions, roles, and regulatory networks of these five KLFs in HCC, summarize key pathways, and propose areas for further investigation
The reduced expression of KLF17 promoted the motility and proliferation ability of TPC1 cells by altering the expression of tight junction protein 1 and Snai1, and activating the AKT pathway by upregulating inhibitor of DNA binding 1.
mutant p53 enhances cancer progression by inhibiting KLF17 expression in invasive breast carcinoma cells
The reduced expression of KLF17 protein in gastric cancer was correlated with tumor size, pN stage and lymphovascular invasion and was an independent predictor for poor survival in patients undergoing surgery for gastric cancer.
KLF17 might be one of the downstream signalling molecules of DJ-1.
KLF17 may have an oncogenic role during EEC progression via initiating EMT through the regulation of TWIST1
Overall, these findings suggest a repressing role of KLF17 in tumor invasion
it is possible that KLF17 inhibits tumor growth in lung adenocarcinoma.
KLF17 has a role in transcriptional regulation of metastasis by Id1 [review]
KLF17 is a new member of the Sp/KLF family of transcription factors.
demonstrate that KLF17 expression is significantly downregulated in primary human breast cancer samples and that the combined expression pattern of KLF17 and Id1 can serve as a potential biomarker for lymph node metastasis in breast cancer
ZFP393 functions as a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development
Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).
Kruppel-like factor 17
, Kruppel-like transcription factor neptune
, novel kruppel-like factor family protein
, krueppel-like factor 17-like
, Krueppel-like factor 17
, novel zinc-finger protein
, zinc finger protein 393
, germ cell specific zinc finger protein
, germ cell-specific zinc finger protein