anti-Kruppel-Like Factor 2 (Lung) (KLF2) Antibodies

Human Kruppel-Like Factor 2 (Lung) (KLF2) interaction partners

1. Identify Dhh (desert hedgehog) as a downstream effector of Klf2, whose expression in endothelial cells is upregulated by shear stress and decreased by inflammatory cytokines.

2. Down-regulated KLF2 was negatively correlated with SNHG3 in glioma tumorigenesis.SNHG3 epigenetically silences KLF2 through sponging with EZH2.

3. Endothelial cell LOX-1 expression is regulated via fluid shear stress depending on its intensity as well as pattern through the KLF2-AP1 pathway of mechanotransduction.

4. The neurokinin-1 receptor antagonist aprepitant ameliorates oxidized LDL-induced endothelial dysfunction via KLF2

5. our results suggest that KLF2 has potential as a diagnostic biomarker and therapeutic target for the treatment of HCC.

6. GHET1 could epigenetically repress transcription of Kruppel-like factor 2 in hepatocellular carcinoma cells by recruiting PRC2 into KLF2 promoter region and predicts poor prognosis.

7. KLF-2 is a downstream target of LINC00673 in the thyroid carcinoma. Low KLF-2 expression was associated with an unfavorable prognosis in patients with thyroid carcinoma.

8. Mechanistic analyses indicated that DUXAP8 regulates PC cell proliferation partly through downregulation of tumor suppressor CDKN1A and KLF2 expression.

9. The experiments in vitro suggested that knockdown of ZFAS1 repressed bladder cancer cell proliferation via up-regulating KLF2 and NKD2 expression, and inhibited cell migration and invasion via down-regulating ZEB1 and ZEB2 expression.

10. mechanistic experiments uncovered that DLEU1 could recruit LSD1 (lysine specific demethylase 1) to the promoter regions of KLF2 and then suppressed its transcription. In addition, rescue assays revealed that the oncogenic function mediated by DLEU1 in GC was partly by regulating KLF2.

11. Overall, the present work showed that MIF is a shear stress-sensitive cytokine and is transcriptionally regulated by KLF2, suggesting that laminar shear stress exerts its athero-protective effect in part by directly inhibiting pro-inflammatory MIF expression.

12. results confirm the association of the KLF2 and NOTCH2-mutations with shorter median treatment-free survival and suggest the possible usefulness of the identification of these changes for the diagnosis of splenic marginal zone lymphoma.

13. LPS exposure resulted in hypermethylation in KLF2 promoter in HUVECs, which subsequently led to downregulation of the KLF2 expression.

14. The expression of SH3PXD2A-AS1 was inversely correlated with the expression of P57 and KLF2 in Colorectal Cancer tissue samples.

15. Suppression of miR-150 led to up-regulation of KLF2, which in turn protected ATDC5 cells against IL-1-induced injury.

16. Suberanilohydroxamic acid has KLF2-dependent anti-inflammatory effects, repressing vascular inflammation and atherosclerosis.

17. we focused on emphasizing the involvement of KLF2 in health and disease states and how they interact with transcriptional master regulator NF-kappaB.

18. GBP5 and KLF2 may be useful as a diagnostic tool for active tuberculosis, also the two-gene set may serve as surrogate biomarkers for monitoring tuberculosis therapy.

19. Studies indicate that the physiological changes in miR-200b levels during acute hypoxia may actually have a proangiogenic effect through Klf2 downregulation and subsequent stabilization of HIF-1 signaling.

20. The flow-mediated miR-10a expression is regulated by Kruppel-like factor 2 through modulation in RARalpha-RARE binding, with the consequent regulation in GATA6/VCAM-1 in endothelial cells.

Mouse (Murine) Kruppel-Like Factor 2 (Lung) (KLF2) interaction partners

1. Identify Dhh (desert hedgehog) as a downstream effector of Klf2, whose expression in endothelial cells is upregulated by shear stress and decreased by inflammatory cytokines.

2. Small interfering RNA (siRNA)-mediated silencing of KLF2 in RAW 264.7 cells restored the activation of NF-kappaB toward the bactericidal activity and generation of proinflammatory cytokines in the presence of S. aureus.

3. Studied role of Kruppel-like factor 2 (KLF2) and runt related transcription factor 2 (Runx2) in promoting osteoblast differentiation.

4. Endothelial KLF2 and KLF4 control a large segment of the endothelial transcriptome, thereby affecting virtually all key endothelial functions. These studies establish an absolute requirement for KLF2/4 for maintenance of endothelial and vascular integrity in the adult animal.

5. miRNA-92a may function through regulating KLF2.

6. the data revealed that puerarin inhibited the monocyte adhesion in vitro and in vivo and thus reduced atherosclerotic lesions in apoE-/- mice; the protective effects were mediated by activation of ERK5/KLF2 signaling pathway.

7. Suberanilohydroxamic acid has KLF2-dependent anti-inflammatory effects, repressing vascular inflammation and atherosclerosis.

8. any one of Klf2, Klf4 and Klf5 was sufficient to support self-renewal of mouse embryonic stem cells, whereas the removal of all three compromised it.

9. KLF2 induces an antiproliferative secretome, including activin A, which attenuates liver regeneration.

10. miRNA92a targets KLF2 and PTEN signaling to promote human T follicular helper precursors in type 1 diabetes mellitus islet autoimmunity.

11. peripheral tolerance is enhanced or diminished through modulation of Treg trafficking tosecondary lymphoid organs (SLOs), a process that can be controlled by adjusting KLF2 protein levels.

12. KLF2 and KLF4 serve as important regulators that promote hemoglobin alpha expression in the endothelium.

13. Mouse embryos deficient in Orai1, Klf2, or Klf4 showed a significantly reduced lymphatic density and impaired lymphatic development.

14. this study shows that KLF2 governs the degree of dendritic cells activation and hence the intensity of proatherogenic T cell responses

15. Transcription factor Kruppel-like factor 2 (KLF2) of the zinc finger family of DNA-binding proteins has recently emerged as a major molecular switch that controls endothelial homeostasis.

16. A deficiency of KLF2 increased the expression of Notch ligand Jagged2 via hypoxia-inducible factor 1alpha (HIF-1alpha), which led to Th2 amplification.

17. our data demonstrate a protective role of KLF2 against glomerular endothelial cell injury and progression of chronic kidney disease in the model of compensatory renal hypertrophy

18. Under steady-state conditions, KLF2-deficient NK cells alter their expression of homeostatic homing receptors and subsequently undergo apoptosis due to IL-15 starvation.

19. KLF2 knockdown markedly reduced expression of miR-155 in macrophages and macrophage activation.

20. study therefore establishes the pivotal role of Klf2 and Tfcp2l1 in mediating ESC self-renewal promoted by Wnt/beta-catenin signaling.

Xenopus laevis Kruppel-Like Factor 2 (Lung) (KLF2) interaction partners

1. KLF2 and ERG associate in a physical complex and the two proteins synergistically activate transcription of Flk1.

Pig (Porcine) Kruppel-Like Factor 2 (Lung) (KLF2) interaction partners

1. miR-92a coregulates KLF4 and KLF2 expression in arterial endothelium and contributes to phenotype heterogeneity associated with regional atherosusceptibility and protection in vivo.

Zebrafish Kruppel-Like Factor 2 (Lung) (KLF2) interaction partners

1. These studies provide new insights into how Klf2 regulates cardiovascular development and specifically myocardial wall integrity.

2. reveals a beta1 integrin-Klf2-Egfl7-signaling pathway that is tightly regulated by cerebral cavernous malformation proteins

3. used microarray expression profiles of klf2a, klf2b and klf17 knockdown and overexpression embryos to identify Klf target genes, which reveals that Klfs participate in specification of the extraembryonic enveloping layer