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LASP1 encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. Additionally we are shipping LASP1 Kits (14) and LASP1 Proteins (13) and many more products for this protein.
Showing 10 out of 114 products:
Cow (Bovine) Polyclonal LASP1 Primary Antibody for IHC, WB - ABIN2785891
Stone, Merriman, Cantor, Geschwind, Nelson: High density SNP association study of a major autism linkage region on chromosome 17. in Human molecular genetics 2007
Human Polyclonal LASP1 Primary Antibody for ELISA, IHC (p) - ABIN262290
Grunewald, Kammerer, Schulze, Schindler, Honig, Zimmer, Butt: Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells. in Experimental cell research 2006
Human Polyclonal LASP1 Primary Antibody for ELISA, WB - ABIN4330346
Schreiber, Moog-Lutz, Régnier, Chenard, Boeuf, Vonesch, Tomasetto, Rio: Lasp-1, a novel type of actin-binding protein accumulating in cell membrane extensions. in Molecular medicine (Cambridge, Mass.) 1999
Human Polyclonal LASP1 Primary Antibody for ICC, IF - ABIN4330347
Ngan, Northey, Brown, Ursini-Siegel, Siegel: A complex containing LPP and α-actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells. in Journal of cell science 2013
Data shows that LASP1 is significantly upregulated in breast cancer tissues and cell lines, and its upregulation significantly associated with disease progression. Also, LASP1 was identified as a target gene of miR (show MLXIP Antibodies)-133a, and its expression negatively regulated by miR (show MLXIP Antibodies)-133a in breast cancer cells.
An in vitro study showed that overexpression of miR (show MLXIP Antibodies)-133b inhibited the proliferation, migration, and invasion of HepG2 and Hep3B cells. Similarly, knockdown of LASP1 reduced HepG2 and Hep3B cell proliferation, migration, and invasion.
Findings indicated that LASP-1, as a downstream target of SOX9 (show SOX9 Antibodies), may act as a novel biomarker for lung cancer and plays an important role in cell proliferation, migration, and invasion.
miR (show MLXIP Antibodies)-203a-3p suppresses tumor growth and metastasis through targeting LASP1 in NPC (show NPC1 Antibodies).
LASP1 silencing elicited effects similar to miR (show MLXIP Antibodies)-326 overexpression on HCC (show FAM126A Antibodies) cells.
A combination of low 14-3-3sigma and high LASP1 expression shows a worse trend with overall survival of colorectal cancer patients.
Furthermore, we identify flotillin-1 (FLOT1 (show FLOT1 Antibodies)) and histone H1 (show H1F0 Antibodies) as downstream factors for cytoplasmic and nuclear pathway of S100A11 (show S100A11 Antibodies), which are required for LASP1-S100A11 (show S100A11 Antibodies) axis-mediated epithelial-mesenchymal transition and colorectal cancer progression.
Overexpression of LASP-1 in thyroid cancer tissues.LASP-1 role in thyroid cancer cell proliferation and invasion.LASP-1 is an oncogene (show RAB1A Antibodies).
Study found LASP1 to be downregulated after knockdown of PVT1 and overexpression of LASP1 attenuated the tumor-suppressive roles of PVT1 knockdown in esophageal squamous cell carcinoma.
Data indicate that LIM and SH3 protein 1 (LASP1) is a direct target of miR (show MLXIP Antibodies)-145.
Results defined LASP1 as a direct target gene for HIF1alpha (show HIF1A Antibodies) upregulation that is critical for metastatic progression of PDAC.
Data show that MEFs derived from Lasp1(-/-) mice migrated more rapidly in vitro.
LIM-nebulette (show NEBL Antibodies), Lasp-1, and zyxin (show ZYX Antibodies) may play an important role in the organization of focal adhesions
Lasp-1 is a dynamic focal adhesion protein necessary for cell migration and survival in response to growth factors and ECM (show MMRN1 Antibodies) proteins.
Data suggest that there are no functional differences between human and mouse LASP-1.
The role of Lasp1 in the regulation of hydrochloride secretion in vivo was studied in a murine model with a targeted disruption of the Lasp-1 gene.
role of Lasp1 in chondrocyte differentiation during cartilage to bone transition
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer.
LIM and SH3 domain protein 1
, LIM and SH3 protein 1
, lasp1 protein
, metastatic lymph node gene 50 protein
, MLN 50
, 40 kDa phosphoprotein
, phosphoprotein Lasp-1