anti-LIM and SH3 Protein 1 (LASP1) Antibodies

Human LIM and SH3 Protein 1 (LASP1) interaction partners

1. HBX contributes to LASP-1 expression via the activation of c-Jun to increase the promoter activity of LASP-1.

2. LASP1 enhances cell proliferation, plate cloning, metastasis and invasion, G2/M phase transition of cell cycle, promotes lung metastasis in nude mice and docetaxel resistance of oral squamous cell carcinoma cell line HN30.

3. Low expression of microRNA-203 could promote the invasion and inhibit apoptosis of laryngeal cancer cells viainhibiting LASP1. microRNA-203 and LASP1 both play a very important role in the development of laryngeal cancer

4. LASP1 activates the PI3K/AKT signaling pathway and is downregulated by miR-377-3p during glioma progression.

5. LASP1 may function as an oncogene in glioblastoma and regulate cell proliferation and chemosensitivity in a PI3K/AKT-dependent mechanism.

6. A positive correlation was found between the expression of LASP1 and COPS5 while a negative correlation existed between 14-3-3sigma and COPS5/LASP1 in most CRC samples.

7. Data shows that LASP1 is significantly upregulated in breast cancer tissues and cell lines, and its upregulation significantly associated with disease progression. Also, LASP1 was identified as a target gene of miR-133a, and its expression negatively regulated by miR-133a in breast cancer cells.

8. An in vitro study showed that overexpression of miR-133b inhibited the proliferation, migration, and invasion of HepG2 and Hep3B cells. Similarly, knockdown of LASP1 reduced HepG2 and Hep3B cell proliferation, migration, and invasion.

9. Findings indicated that LASP-1, as a downstream target of SOX9, may act as a novel biomarker for lung cancer and plays an important role in cell proliferation, migration, and invasion.

10. miR-203a-3p suppresses tumor growth and metastasis through targeting LASP1 in NPC.

11. LASP1 silencing elicited effects similar to miR-326 overexpression on HCC cells.

12. A combination of low 14-3-3sigma and high LASP1 expression shows a worse trend with overall survival of colorectal cancer patients.

13. Furthermore, we identify flotillin-1 (FLOT1) and histone H1 as downstream factors for cytoplasmic and nuclear pathway of S100A11, which are required for LASP1-S100A11 axis-mediated epithelial-mesenchymal transition and colorectal cancer progression.

14. Overexpression of LASP-1 in thyroid cancer tissues.LASP-1 role in thyroid cancer cell proliferation and invasion.LASP-1 is an oncogene.

15. Study found LASP1 to be downregulated after knockdown of PVT1 and overexpression of LASP1 attenuated the tumor-suppressive roles of PVT1 knockdown in esophageal squamous cell carcinoma.

16. Data indicate that LIM and SH3 protein 1 (LASP1) is a direct target of miR-145.

17. LASP1 enhances the expression and secretion of MMPs, favoring breast cancer cell migration and invasiveness.

18. miR-218 contributes to PE by targeting LASP1 to inhibit trophoblast invasion

19. The correlation between LIM and SH3 domain-containing protein expression levels in cancer and the poor outcome and metastatic behavior of tumors denotes the clinical significance of this protein and hints its potential value as a new cancer prognostic or even diagnostic biomarker

20. LASP-1 contributes to the formation and progression of prostate cancer through a NF-kappaappa B pathway.

Mouse (Murine) LIM and SH3 Protein 1 (LASP1) interaction partners

1. Results defined LASP1 as a direct target gene for HIF1alpha upregulation that is critical for metastatic progression of PDAC.

2. Data show that MEFs derived from Lasp1(-/-) mice migrated more rapidly in vitro.

3. LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions

4. Lasp-1 is a dynamic focal adhesion protein necessary for cell migration and survival in response to growth factors and ECM proteins.

5. Data suggest that there are no functional differences between human and mouse LASP-1.

6. The role of Lasp1 in the regulation of hydrochloride secretion in vivo was studied in a murine model with a targeted disruption of the Lasp-1 gene.

7. role of Lasp1 in chondrocyte differentiation during cartilage to bone transition