anti-LIM and SH3 Protein 1 (LASP1) Antibodies

LASP1 encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. Additionally we are shipping LASP1 Proteins (13) and LASP1 Kits (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LASP1 3927 Q14847
LASP1 16796 Q61792
LASP1 29278 Q99MZ8
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Top anti-LASP1 Antibodies at antibodies-online.com

Showing 10 out of 114 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-LASP1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:2500 Positive Control: MCF7 cell lysate 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB Rabbit Anti-LASP1 Antibody Catalog Number: ARP54798_P050 Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Cytoplasmic Primary Antibody Concentration: N/A Other Working Concentrations: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec WB Suggested Anti-LASP1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: HepG2 cell lysate LASP1 is supported by BioGPS gene expression data to be expressed in HepG2 100 μL 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB ABIN184658 staining (0.1µg/ml) of Human Brain (Cerebellum) extracts (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Human Goat Un-conjugated ELISA, IHC, WB ABIN238605 (0.1µg/ml) staining of Human Kidney lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated ICC, IHC (p), WB Anti-LASP1 antibody,  Western blotting Lane 1: HELA Cell Lysate Lane 2: MCF-7 Cell Lysate Anti-LASP1 antibody, ICC ICC: A549 Cell 100 μg 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-LASP1 antibody, IHC(P): Human Placenta Tissue Anti-LASP1 antibody, Western blotting Lane 1: HELA Cell Lysate Lane 2: MCF-7 Cell Lysate 100 μg 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of LASP1 Antibody (Center) in A549 cell line lysates (35ug/lane). This demonstrates the LASP1 antibody detected the LASP1 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 to 14 Days
$484.00
Details
Dog Goat Un-conjugated WB   0.1 mg 4 to 8 Days
$462.00
Details
Cow Rabbit Un-conjugated WB   200 μL 13 to 14 Days
$487.50
Details

Top referenced anti-LASP1 Antibodies

  1. Cow (Bovine) Polyclonal LASP1 Primary Antibody for WB - ABIN2785890 : Stone, Merriman, Cantor, Geschwind, Nelson: High density SNP association study of a major autism linkage region on chromosome 17. in Human molecular genetics 2007 (PubMed)

  2. Chicken Polyclonal LASP1 Primary Antibody for ELISA, WB - ABIN546771 : Li, Hornshaw, van Minnen, Smalla, Gundelfinger, Smit et al.: Organelle proteomics of rat synaptic proteins: correlation-profiling by isotope-coded affinity tagging in conjunction with liquid chromatography-tandem mass spectrometry to reveal post-synaptic ... in Journal of proteome research 2005 (PubMed)

  3. Dog (Canine) Polyclonal LASP1 Primary Antibody for ELISA, WB - ABIN548038 : Grunewald, Kammerer, Schulze, Schindler, Honig, Zimmer, Butt: Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells. in Experimental cell research 2006 (PubMed)

  4. Human Polyclonal LASP1 Primary Antibody for ELISA, WB - ABIN4330346 : Schreiber, Moog-Lutz, Régnier, Chenard, Boeuf, Vonesch, Tomasetto, Rio: Lasp-1, a novel type of actin-binding protein accumulating in cell membrane extensions. in Molecular medicine (Cambridge, Mass.) 1999 (PubMed)

  5. Human Polyclonal LASP1 Primary Antibody for ICC, IF - ABIN4330347 : Ngan, Northey, Brown, Ursini-Siegel, Siegel: A complex containing LPP and α-actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells. in Journal of cell science 2013 (PubMed)

More Antibodies against LASP1 Interaction Partners

Human LIM and SH3 Protein 1 (LASP1) interaction partners

  1. HBX contributes to LASP-1 expression via the activation of c-Jun to increase the promoter activity of LASP-1.

  2. LASP1 enhances cell proliferation, plate cloning, metastasis and invasion, G2/M phase transition of cell cycle, promotes lung metastasis in nude mice and docetaxel resistance of oral squamous cell carcinoma cell line HN30.

  3. Low expression of microRNA-203 could promote the invasion and inhibit apoptosis of laryngeal cancer cells viainhibiting LASP1. microRNA-203 and LASP1 both play a very important role in the development of laryngeal cancer

  4. LASP1 activates the PI3K/AKT signaling pathway and is downregulated by miR-377-3p during glioma progression.

  5. LASP1 may function as an oncogene in glioblastoma and regulate cell proliferation and chemosensitivity in a PI3K/AKT-dependent mechanism.

  6. A positive correlation was found between the expression of LASP1 and COPS5 while a negative correlation existed between 14-3-3sigma and COPS5/LASP1 in most CRC samples.

  7. Data shows that LASP1 is significantly upregulated in breast cancer tissues and cell lines, and its upregulation significantly associated with disease progression. Also, LASP1 was identified as a target gene of miR-133a, and its expression negatively regulated by miR-133a in breast cancer cells.

  8. An in vitro study showed that overexpression of miR-133b inhibited the proliferation, migration, and invasion of HepG2 and Hep3B cells. Similarly, knockdown of LASP1 reduced HepG2 and Hep3B cell proliferation, migration, and invasion.

  9. Findings indicated that LASP-1, as a downstream target of SOX9, may act as a novel biomarker for lung cancer and plays an important role in cell proliferation, migration, and invasion.

  10. miR-203a-3p suppresses tumor growth and metastasis through targeting LASP1 in NPC.

  11. LASP1 silencing elicited effects similar to miR-326 overexpression on HCC cells.

  12. A combination of low 14-3-3sigma and high LASP1 expression shows a worse trend with overall survival of colorectal cancer patients.

  13. Furthermore, we identify flotillin-1 (FLOT1) and histone H1 as downstream factors for cytoplasmic and nuclear pathway of S100A11, which are required for LASP1-S100A11 axis-mediated epithelial-mesenchymal transition and colorectal cancer progression.

  14. Overexpression of LASP-1 in thyroid cancer tissues.LASP-1 role in thyroid cancer cell proliferation and invasion.LASP-1 is an oncogene.

  15. Study found LASP1 to be downregulated after knockdown of PVT1 and overexpression of LASP1 attenuated the tumor-suppressive roles of PVT1 knockdown in esophageal squamous cell carcinoma.

  16. Data indicate that LIM and SH3 protein 1 (LASP1) is a direct target of miR-145.

  17. LASP1 enhances the expression and secretion of MMPs, favoring breast cancer cell migration and invasiveness.

  18. miR-218 contributes to PE by targeting LASP1 to inhibit trophoblast invasion

  19. The correlation between LIM and SH3 domain-containing protein expression levels in cancer and the poor outcome and metastatic behavior of tumors denotes the clinical significance of this protein and hints its potential value as a new cancer prognostic or even diagnostic biomarker

  20. LASP-1 contributes to the formation and progression of prostate cancer through a NF-kappaappa B pathway.

Mouse (Murine) LIM and SH3 Protein 1 (LASP1) interaction partners

  1. Results defined LASP1 as a direct target gene for HIF1alpha upregulation that is critical for metastatic progression of PDAC.

  2. Data show that MEFs derived from Lasp1(-/-) mice migrated more rapidly in vitro.

  3. LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions

  4. Lasp-1 is a dynamic focal adhesion protein necessary for cell migration and survival in response to growth factors and ECM proteins.

  5. Data suggest that there are no functional differences between human and mouse LASP-1.

  6. The role of Lasp1 in the regulation of hydrochloride secretion in vivo was studied in a murine model with a targeted disruption of the Lasp-1 gene.

  7. role of Lasp1 in chondrocyte differentiation during cartilage to bone transition

LASP1 Antigen Profile

Protein Summary

This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer.

Gene names and symbols associated with LASP1

  • LIM and SH3 protein 1 (lasp1) antibody
  • LIM and SH3 protein 1 L homeolog (lasp1.L) antibody
  • LIM and SH3 protein 1 (LASP1) antibody
  • LIM and SH3 protein 1 (Lasp1) antibody
  • AA408629 antibody
  • Def-4 antibody
  • fb92f05 antibody
  • lasp-1 antibody
  • LASP1 antibody
  • MGC53336 antibody
  • MGC89667 antibody
  • mln50 antibody
  • SH3P6 antibody
  • Tg(Col1a1-lacZ)1Ngma antibody
  • wu:fb92f05 antibody
  • zgc:77542 antibody

Protein level used designations for LASP1

LIM and SH3 domain protein 1 , LIM and SH3 protein 1 , lasp1 protein , metastatic lymph node gene 50 protein , LASP-1 , MLN 50 , Tg(11Col1a1)NG , 40 kDa phosphoprotein , phosphoprotein Lasp-1 , pp40

GENE ID SPECIES
100195513 Salmo salar
380354 Xenopus laevis
454620 Pan troglodytes
493322 Xenopus (Silurana) tropicalis
694950 Macaca mulatta
420002 Gallus gallus
3927 Homo sapiens
16796 Mus musculus
29278 Rattus norvegicus
608624 Canis lupus familiaris
323216 Danio rerio
495167 Xenopus laevis
532851 Bos taurus
100009568 Oryctolagus cuniculus
100173670 Pongo abelii
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