anti-Laminin, alpha 2 (LAMA2) Antibodies

Laminin, an extracellular protein, is a major component of the basement membrane. Additionally we are shipping Laminin Kits (6) and Laminin Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LAMA2 3908 P24043
LAMA2 16773  
LAMA2 309368  
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Top anti-Laminin Antibodies at antibodies-online.com

Showing 10 out of 46 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Anti-Laminin 2 alpha antibody, Western blotting Lane 1: HELA Cell Lysate Lane 2: A549 Cell Lysate Lane 3: PANC Cell Lysate 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Mouse Un-conjugated IHC, IHC (p), WB Immunohistochemistry: Laminin alpha 2 Antibody (3450) [NBP2-46624] - Lane 1: Marker [kDa] 460, 268, 238, 171, 117, 71, 55, 41, 31. Lane 2: Purified human recombinant protein Laminin-211. Lane 3: Purified human recombinant protein Laminin-221. Lane 4: Purified human recombinant protein Laminin-332. Lane 5: Purified huma Immunohistochemistry: Laminin alpha 2 Antibody (3450) [NBP2-46624] - Analysis of human pancreas shows positivity in basement membrane of glandular epithelium. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Mouse Un-conjugated ELISA, IHC, WB Immunoperoxidase of monoclonal antibody to LAMA2 on formalin-fixed paraffin-embedded human pancreas (antibody concentration 1 µg/mL). Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.84 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human placenta tissue, using LAMA2 Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of NIH-3T3 cells, using LAMA2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000; TMB staining; Read the data in MicroplateReader by 450 Formalin-fixed and paraffin embedded human bladder carcinoma labeled with Rabbit Anti LAMA2 Polyclonal Antibody, Unconjugated (ABIN1387552) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$329.45
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p) 100 μL Log in to see 11 to 14 Days
$493.17
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to LAMA2 on formalin-fixed paraffin-embedded human pancreas. [antibody concentration 1 ug/ml] Detection limit for recombinant GST tagged LAMA2 is 1 ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
$440.00
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Mouse Tissue 100 μg Log in to see 13 to 16 Days
$360.00
Details
Human Rabbit Un-conjugated ELISA, IF, IHC   100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$428.45
Details

Top referenced anti-Laminin Antibodies

  1. Human Polyclonal Laminin Primary Antibody for WB - ABIN3042862 : Chen, Wan, Xia, Guo, Wang, Liu, Li: Promoted regeneration of mature blood vessels by electrospun fibers with loaded multiple pDNA-calcium phosphate nanoparticles. in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fu?r Pharmazeutische Verfahrenstechnik e.V 2013 (PubMed)
    Show all 13 Pubmed References

  2. Human Monoclonal Laminin Primary Antibody for IHC (p), ELISA - ABIN561638 : Lemons, Feng, Bennett, Legesse-Miller, Johnson, Raitman, Pollina, Rabitz, Rabinowitz, Coller: Quiescent fibroblasts exhibit high metabolic activity. in PLoS biology 2010 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal Laminin Primary Antibody for IF (p), IHC (p) - ABIN1387552 : Barreto, Romagnolli, Mess, Miglino: Decellularized bovine cotyledons may serve as biological scaffolds with preserved vascular arrangement. in Journal of tissue engineering and regenerative medicine 1970 (PubMed)

More Antibodies against Laminin Interaction Partners

Zebrafish Laminin, alpha 2 (LAMA2) interaction partners

  1. analysis of the caf zebrafish model of MDC1A, which has a mutation in LAMA2

  2. The degenerative muscle phenotype in the zebrafish dystrophic mutant, candyfloss (caf) results from mutations in the laminin alpha2 (lama2) gene.

  3. splice site mutation in laminin-alpha2 results in a severe muscular dystrophy and growth abnormalities

Human Laminin, alpha 2 (LAMA2) interaction partners

  1. Merosin-deficient congenital muscular dystrophy (MDC1A) is a rare autosomal recessive genetic disease that occurred due to novel mutations in the LAMA2 gene

  2. The LAMA2 Mutation Congenital Muscular Dystrophy showed demyelinating polyneuropathy white matter changes on brain.

  3. It was established that the frequency of individuals with the COL13A1*D/*D genotype was higher in the senile age period. The LAMA2*I/*D genotype was predisposing to longevity among women.

  4. Using high-throughput technology identify LAMA-2 as a candidate medullary sponge kidney disease biomarker possibly employable in future for the early diagnosis of this disease.

  5. Differential protein expression of collagen IV, laminin alpha2, and nidogen-1 indicated basal lamina remodeling develops in ischemic failing versus nonfailing human hearts.

  6. Next generation sequencing was found to be useful for molecular diagnosis of a confirmed case of merosin deficient congenital muscular dystrophy.

  7. did not find positive association signals of the four single nucleotide polymorphisms in the LAMA2 and EGR1 genes with high myopia

  8. By analyzing the gene test we found that compound heterozygous LAMA2 mutation inherited from the parents. One coming from the father was a gross deletion expanding from exon 36 to exon 65. The from the mother was a missense mutation c.1358G>C

  9. This report widens the clinical spectrum of cerebral manifestations related with mutations in LAMA2

  10. Data showed miR-29a/c as novel regulators of LAMA2 in ependymoma based on miRNA-mRNA covariation and sequence-based target predictions.

  11. This study demonstrates a wide clinical spectrum of LAMA2-related muscular dystrophy and its prevalence in an LGMD2 cohort, which indicates that LAMA2 muscular dystrophy should be included in the LGMD2 nomenclature.

  12. Crystal structure of LAMM L4 domain

  13. Data find high frequency mutations in LAMA2 protein in hepatocellular carcinoma (HCC) patients. Its lower expression levels correlate with tumor progression, poor survival and higher chance of cancer recurrence.

  14. Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line.

  15. 2 patients with partial laminin-alpha2 deficiency and atypical phenotypes, one with almost exclusive central nervous system involvement and second with cardiac dysfunction, rigid spine syndrome and limb-girdle weakness; both have 2 heterozygous LAMA2 variants sharing a potentially pathogenic missense mutation c.2461A>C located in exon 18

  16. Genetic association studies identified two pathogenic mutations in the LAMA2 gene in patients with congenital muscular dystrophy.

  17. Homozygous truncating mutations in POMK lead to congenital muscular dystrophies with secondary merosin deficiency, hypomyelination and intellectual disability.

  18. children with LAMA2 congenital muscular dystrophy may be at nogreater risk of developing malignant hyperthermia than the general population

  19. Identification of cell adhesive sequences in the N-terminal region of the laminin alpha2 chain.

  20. Aberrant methylation at target CpG sites in GABRA1 and LAMA2 was observed with high frequency in tumor tissues.

Mouse (Murine) Laminin, alpha 2 (LAMA2) interaction partners

  1. These findings provide a mechanistic understanding of LAMA2 muscular dystrophy and establish a strong basis for a potential treatment.

  2. Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.

  3. Deletion of integrin alpha7 subunit does not aggravate the phenotype of laminin alpha2 chain-deficient mice. laminin-211 and integrin alpha7beta1 have intersecting roles in skeletal muscle.

  4. results indicate a novel role for laminin-dystroglycan interactions in the cooperative integration of astrocytes, endothelial cells, and pericytes in regulating the Blood Brain Barrier.

  5. Laminin alpha2-mediated FAK activation in podocytes is an important early event in Alport glomerular pathogenesis.

  6. The effects of merosin knockout on alkaline phosphatase activity in the liver of normal and dystrophic mice is reported.

  7. Remodeling of extracellular matrix protein laminin may constitute an effort to revascularize and oxygenate the tissue following ischemic injury.

  8. The data of this study suggested that prosurvival Lama interactions in the developing postnatal VZ-SVZ germinal zone regulate the ability, or timing, of oligodendrocyte production to occur appropriately.

  9. Identification of cell adhesive sequences in the N-terminal region of the laminin alpha2 chain.

  10. -DG prepared from lung- or testis-derived cells lacks the post-phosphoryl moiety and shows little laminin a1 and a2 binding activity.

  11. Expression of autophagy-related genes is upregulated in laminin alpha2 chain-deficient muscle.

  12. alpha7 integrin is a modifier of disease progression in laminin-alpha2-deficient mice.

  13. Levels of both lipid rafts and raft-located acetylcholinesterase dimers increase in muscle of mice with muscular dystrophy by merosin deficiency.

  14. Overexpression of laminin alpha1 chain that lacks the dystroglycan binding LG4-5 domains in alpha2 chain deficient mice resulted in prolonged lifespan and improved health.

  15. we analyze the lifespan of laminin alpha2 chain-deficient mice with transgenic overexpression of laminin alpha1 chain

  16. These results suggest that the A2G78 and A2G80 sites play functional roles as heparan sulfate- and alpha-dystroglycan-binding sites in the laminin alpha2 chain LG4-5 module.

  17. Ku70 is a regulator of Bax-mediated pathogenesis in laminin-alpha2-deficiency muscle cells.

  18. Expression and distribution of laminin alpha2 in embryonic and adult mouse tissues

  19. this study identified a novel spontaneous mouse model of human congenital muscular dystrophy with laminin alpha2 chain deficiency, named dy(Pas)/dy(Pas). Homozygous animals rapidly developed a progressive muscular dystrophy leading to premature death.

  20. merosin contributes to muscle passive stiffness, viscoelasticity, and contractility

Laminin (LAMA2) Antigen Profile

Protein Summary

Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.

Gene names and symbols associated with LAMA2

  • laminin subunit alpha 2 (LAMA2) antibody
  • laminin, alpha 2 (LAMA2) antibody
  • laminin, alpha 2 (lama2) antibody
  • laminin subunit alpha-2 (LOC100460380) antibody
  • laminin subunit alpha-2 (LOC100545053) antibody
  • laminin subunit alpha 2 (lama2) antibody
  • laminin, alpha 2 (Lama2) antibody
  • laminin subunit alpha 2 (Lama2) antibody
  • 5830440B04 antibody
  • dy antibody
  • LAMA2 antibody
  • LAMM antibody
  • mer antibody
  • merosin antibody
  • mKIAA4087 antibody

Protein level used designations for LAMA2

laminin alpha 2 subunit , laminin, alpha 2 (merosin, congenital muscular dystrophy) , laminin, alpha 2 , caf , candyfloss , laminin alpha 2 chain , unm teg15a , unm tk209 , laminin subunit alpha-2-like , laminin M chain , laminin subunit alpha-2 , laminin-12 subunit alpha , laminin-2 subunit alpha , laminin-4 subunit alpha , merosin heavy chain , dystrophia muscularis

GENE ID SPECIES
472122 Pan troglodytes
484121 Canis lupus familiaris
100049705 Danio rerio
100405831 Callithrix jacchus
100460380 Pongo abelii
100484712 Ailuropoda melanoleuca
100545053 Meleagris gallopavo
100565785 Anolis carolinensis
100583654 Nomascus leucogenys
3908 Homo sapiens
100350500 Oryctolagus cuniculus
16773 Mus musculus
309368 Rattus norvegicus
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