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Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. Additionally we are shipping Lectin, Galactoside-Binding, Soluble, 13 Antibodies (121) and Lectin, Galactoside-Binding, Soluble, 13 Kits (32) and many more products for this protein.
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First-trimester PP-13 levels are significantly correlated with BMI and smoking. These correlations appear independent of uterine and umbilical artery resistance. In low risk patients, PP-13 levels fail to predict the risk for pre-eclampsia or small for gestational age (SGA) neonates.
Gal-3 was significantly downregulated only in the extravillous trophoblast of intrauterine growth restriction ( IUGR) placentas. In contrast, expressions of gal-2 and gal-13 were downregulated in both villous and extravillous trophoblast cells of IUGR placentas.
Placental protein 13 was localized to syncytiotrophoblasts in the chorionic villi and to occasional multinucleated luminal trophoblasts within converted decidual spiral arterioles in preeclampsia patients.
study provides a basis for replenishing patients at risk for preeclampsia by the full length but not the truncated PP13
As gal-13 with its anti-inflammatory functions plays a role in maternal immune system, a lack of gal-13 may contribute to an imbalance in inflammation processes in the placenta during pregnancy and therefore influences development of gestational diabetes.
Evaluation of placental protein 13 (PP13) and risk factors as markers for predicting preeclampsia.
Data in rats suggest that human LGALS13 plays role in maintaining uteroplacental blood flow and plays possible role in facilitating proper adaptation of maternal vasculature to pregnancy.
The maternal serum level of placental protein 13 is significantly lower in Egyptian patients with pre-eclampsia compared to controls.
secretion of PAPP-A (show PAPPA Proteins), ADAM12 (show ADAM12 Proteins) and PP13 is closely related to the size of the placenta in the beginning of pregnancy. After 8 weeks of pregnancy, which is the time for luteoplacental shift, the correlation disappears.
PP13 is released from the syncytiotrophoblast in preterm preeclampsia and HELLP, mimicked in BeWo cells by ischemic stress, suggesting PP13 is a placental alarmin.
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene has lysophospholipase activity. It is composed of two identical subunits which are held together by disulfide bonds. This protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family.
, galactoside-binding soluble lectin 13
, galectin 13
, placental protein 13
, placental tissue protein 13
, Beta-defensin 13
, beta-defensin 13