anti-Lectin, Mannose-Binding, 1 (LMAN1) Antibodies

The protein encoded by LMAN1 is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. Additionally we are shipping LMAN1 Kits (8) and LMAN1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LMAN1 3998 P49257
LMAN1 70361 Q9D0F3
LMAN1 116666 Q62902
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Top anti-LMAN1 Antibodies at antibodies-online.com

Showing 10 out of 51 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-LMAN1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human heart Host:  Rabbit  Target Name:  NOP56  Sample Type:  Human Fetal Muscle  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Mouse Un-conjugated FACS, ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: LMAN1 Antibody (1A8) [NBP2-03381] - Staining of paraffin-embedded Human Kidney tissue using anti-LMAN1 mouse monoclonal antibody. Immunocytochemistry/Immunofluorescence: LMAN1 Antibody (1A8) [NBP2-03381] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY LMAN1. 0.1 mL Log in to see 8 to 11 Days
$559.35
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-LMAN1 Antibody Titration:  1.25ug/ml  Positive Control:  HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$360.00
Details
Bat Rabbit Un-conjugated WB 100 μg Log in to see 11 to 14 Days
$493.17
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of LMAN1 using mouse brain lysates 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB Anti-LMAN1 mouse monoclonal antibody (ABIN2454009) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LMAN1 (RC207088). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LMAN1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LMAN1. 0.1 mL Log in to see 2 to 3 Days
$462.00
Details
Human Mouse Un-conjugated WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LMAN1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LMAN1. 0.1 mL Log in to see 2 to 3 Days
$462.00
Details
Human Mouse Un-conjugated IF, WB Anti-LMAN1 mouse monoclonal antibody (ABIN2453990) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LMAN1 (RC207088). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LMAN1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LMAN1. 0.1 mL Log in to see 2 to 3 Days
$462.00
Details

Top referenced anti-LMAN1 Antibodies

  1. Dog (Canine) Monoclonal LMAN1 Primary Antibody for FACS, ICC - ABIN4331217 : Gerondopoulos, Bastos, Yoshimura, Anderson, Carpanini, Aligianis, Handley, Barr: Rab18 and a Rab18 GEF complex are required for normal ER structure. in The Journal of cell biology 2014 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal LMAN1 Primary Antibody for IHC, IHC (p) - ABIN4331216 : Roeckel, Woerner, Kloor, Yuan, Patsos, Gromes, Kopitz, Gebert: High frequency of LMAN1 abnormalities in colorectal tumors with microsatellite instability. in Cancer research 2009 (PubMed)

More Antibodies against LMAN1 Interaction Partners

Human Lectin, Mannose-Binding, 1 (LMAN1) interaction partners

  1. that Multiple coagulation factor deficiency protein 2 promotes cancer metastasis by regulating lectin mannose binding 1 and level of galactoside-binding soluble 3 binding protein expression levels

  2. Combined deficiency of factors V and VIII by chance coinheritance of parahaemophilia and haemophilia A, but not by mutations of either LMAN1 or MCFD2

  3. Genetic variants in the exon1 of MBL gene per se are not risk factors for Systemic lupus erythematosus (SLE) in South Indian Tamils. However, the association of codon 54 (rs1800450) with medium vessel vasculitis suggests that it may be a genetic modifier of clinical phenotype in SLE.

  4. Mannan-binding lectin reduces CpG DNA-induced inflammatory cytokine production in monocytes.

  5. MMP-9 secretion was reduced in the LMAN1 knockout cell line compared to control cells confirming the functional role of LMAN1.

  6. Authors identified a class of pathogen-derived ERGIC-53 ligands, a lectin-independent basis for their association with ERGIC-53, and a role for ERGIC-53 in the propagation of several highly pathogenic RNA virus families.

  7. Studies indicate that the LMAN1-CRD contains distinct, separable binding sites for both its partner protein MCFD2 and the cargo proteins FV/FVIII.

  8. Data indicate that together with its soluble coreceptor MCFD2, LMAN1 transports coagulation factors V (FV) and VIII (FVIII).

  9. Mutations in LMAN1 lead to F5F8D (combined deficiency of factor V And factor VIII) due to alterations in LMAN1-MCFD2 complex of coat protein (COP)II complex trafficking machinery; 70% of F5F8D patients have mutations in LMAN1. [REVIEW]

  10. UBXD1 modulates the trafficking of ERGIC-53-containing vesicles by controlling the interaction of transport factors with the cytoplasmic tail of ERGIC-53.

  11. Two new mutations at ERGIC-53 gene in a Turkish family.

  12. Data present the crystal structure of the LMAN1/MCFD2 complex and relate it to patient mutations. Circular dichroism data show that the majority of the substitution mutations give rise to a disordered or severely destabilized MCFD2 protein.

  13. Data show that mutations in MCFD2 that disrupt the tertiary structure and abolish LMAN1 binding still retain the FV/FVIII binding activities, suggesting that this interaction is independent of Ca(2+)-induced folding of the protein.

  14. Among Papua New Guinea malaria patients, 2 new mannose-binding lectin polymorphic promoter sites were found: one in the untranslated region at position +1 (G-->A, termed R/S), and the 2nd upstream of the gene at position -4 (G-->A, termed T/U).

  15. MBL deficiency is not a risk factor for SLE in women from the Canary Islands, but it is associated with lower prevalence of autoantibodies and with later age at disease onset and at SLE diagnosis.

  16. inactivating mutations in MCFD2 cause combined deficiency of factor V and factor VIII with a phenotype indistinguishable from that caused by mutations in LMAN1

  17. Data show that the mRNA of lectin ERGIC-53 and its related protein VIP36 is induced by the known inducers of endoplasmic reticulum stress, tunicamycin and thapsigargin.

  18. an interaction between LMAN1 and FVIII in vivo was mediated via high mannose-containing asparagine-linked oligosaccharides that are densely situated within the B domain of FVIII, as well as protein-protein interactions

  19. Results describe the x-ray structure of human mannan-binding lectin-associated protein 19 (MAp19), and identify the residues involved in the interaction of MAp19 with mannan-binding lectin and L-ficolin.

  20. surfactant proteins A and D and mannose-binding lectin play roles in inflammation caused by DNA in lungs and other tissues

Mouse (Murine) Lectin, Mannose-Binding, 1 (LMAN1) interaction partners

  1. MCFD2-deficient mice generated by gene targeting also demonstrate reduced plasma FV and FVIII, with levels lower than those in LMAN1-deficient mice, similar to previous observations in LMAN1- and MCDF2-deficient humans.

  2. LMAN1 may play a role in photoreceptor gene transport and homeostasis.

  3. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of alpha1-antitrypsin.

  4. surfactant proteins A and D and mannose-binding lectin play roles in inflammation caused by DNA in lungs and other tissues

  5. These results indicate that increased levels of cargo receptor proteins might have a function either in the quality control of protein folding in the endoplasmic reticulum or in the homeostasis of the intermediate compartment and Golgi complex.

  6. ERGIC-53 gene transcription is regulated in response to endoplasmic reticulum stress

LMAN1 Antigen Profile

Protein Summary

The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.

Gene names and symbols associated with LMAN1

  • lectin, mannose binding 1 (LMAN1) antibody
  • lectin, mannose-binding, 1 (Lman1) antibody
  • complexin 3 (cplx3) antibody
  • lectin, mannose-binding, 1 (lman1) antibody
  • lectin, mannose binding 1 (lman1) antibody
  • lectin, mannose binding 1 S homeolog (lman1.S) antibody
  • lectin, mannose binding 1 (Lman1) antibody
  • 2610020P13Rik antibody
  • AI326273 antibody
  • AU043785 antibody
  • C730041J05 antibody
  • cpx-iii antibody
  • cpxiii antibody
  • ERGIC-53 antibody
  • ERGIC53 antibody
  • F5F8D antibody
  • FMFD1 antibody
  • gp58 antibody
  • lman1 antibody
  • lman1-a antibody
  • MCFD1 antibody
  • MR60 antibody
  • p58 antibody
  • wu:fc54c09 antibody
  • wu:fi36e01 antibody
  • Xp58 antibody

Protein level used designations for LMAN1

ER-Golgi intermediate compartment 53 kDa protein , endoplasmic reticulum-golgi intermediate compartment protein 53 , intracellular mannose specific lectin , intracellular mannose-specific lectin MR60 , protein ERGIC-53 , lectin, mannose-binding, 1 , lectin mannose-binding 1 , fc54c09 , fi36e01 , protein ERGIC-53-like , ERGIC-53 protein , intracellular mannose specific lectin MR60 , LOW QUALITY PROTEIN: protein ERGIC-53

GENE ID SPECIES
3998 Homo sapiens
70361 Mus musculus
116666 Rattus norvegicus
426849 Gallus gallus
455448 Pan troglodytes
476186 Canis lupus familiaris
496634 Xenopus (Silurana) tropicalis
559775 Danio rerio
697449 Macaca mulatta
100021881 Monodelphis domestica
100354112 Oryctolagus cuniculus
100404326 Callithrix jacchus
100475249 Ailuropoda melanoleuca
100562643 Anolis carolinensis
100592766 Nomascus leucogenys
394295 Xenopus laevis
511649 Bos taurus
100728262 Cavia porcellus
Selected quality suppliers for anti-LMAN1 (LMAN1) Antibodies
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