anti-Lectin, Mannose-Binding, 1 (LMAN1) Antibodies

The protein encoded by LMAN1 is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. Additionally we are shipping LMAN1 Kits (8) and LMAN1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LMAN1 3998 P49257
LMAN1 70361 Q9D0F3
LMAN1 116666 Q62902
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Top anti-LMAN1 Antibodies at antibodies-online.com

Showing 10 out of 50 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-LMAN1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: Human heart Host: Rabbit Target Name: NOP56 Sample Type: Human Fetal Muscle Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Mouse Un-conjugated FACS, ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: LMAN1 Antibody (1A8) [NBP2-03381] - Staining of paraffin-embedded Human Kidney tissue using anti-LMAN1 mouse monoclonal antibody. Immunocytochemistry/Immunofluorescence: LMAN1 Antibody (1A8) [NBP2-03381] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY LMAN1. 0.1 mL Log in to see 8 to 11 Days
$556.31
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-LMAN1 Antibody Titration: 1.25ug/ml Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: LMAN1 Antibody [NBP1-84812] - Staining of human duodenum shows strong cytoplasmic positivity with granular pattern in glandular cells. Western Blot: LMAN1 Antibody [NBP1-84812] - Lane 1: Marker [kDa] 230, 110, 82, 49, 32, 26, 18 Lane 2: Human cell line RT-4 Lane 3: Human cell line U-251MG sp Lane 4: Human plasma (IgG/HSA depleted) Lane 5: Human liver tissue Lane 6: Human tonsil tissue 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$350.00
Details
Bat Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Mouse Un-conjugated FACS, IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LMAN1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LMAN1. Flow cytometric Analysis of Hela cells, using anti-LMAN1 antibody (ABIN2454088), (Red), compared to a nonspecific negative control antibody, (Blue). 0.1 mL Log in to see Available
$451.00
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB Anti-LMAN1 mouse monoclonal antibody (ABIN2454009) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LMAN1 (RC207088). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LMAN1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LMAN1. 0.1 mL Log in to see Available
$451.00
Details
Human Mouse Un-conjugated IF, WB Anti-LMAN1 mouse monoclonal antibody (ABIN2453990) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LMAN1 (RC207088). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LMAN1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LMAN1. 0.1 mL Log in to see Available
$451.00
Details

LMAN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-LMAN1 Antibodies

  1. Dog (Canine) Monoclonal LMAN1 Primary Antibody for FACS, ICC - ABIN4331217 : Gerondopoulos, Bastos, Yoshimura, Anderson, Carpanini, Aligianis, Handley, Barr: Rab18 and a Rab18 GEF complex are required for normal ER structure. in The Journal of cell biology 2014 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal LMAN1 Primary Antibody for IHC, IHC (p) - ABIN4331216 : Roeckel, Woerner, Kloor, Yuan, Patsos, Gromes, Kopitz, Gebert: High frequency of LMAN1 abnormalities in colorectal tumors with microsatellite instability. in Cancer research 2009 (PubMed)

More Antibodies against LMAN1 Interaction Partners

Human Lectin, Mannose-Binding, 1 (LMAN1) interaction partners

  1. Genetic variants in the exon1 of MBL gene per se are not risk factors for Systemic lupus erythematosus (SLE) in South Indian Tamils. However, the association of codon 54 (rs1800450) with medium vessel vasculitis suggests that it may be a genetic modifier of clinical phenotype in SLE.

  2. Mannan-binding lectin (show MBL2 Antibodies) reduces CpG DNA-induced inflammatory cytokine production in monocytes.

  3. MMP-9 (show MMP9 Antibodies) secretion was reduced in the LMAN1 knockout cell line compared to control cells confirming the functional role of LMAN1.

  4. Authors identified a class of pathogen-derived ERGIC-53 ligands, a lectin-independent basis for their association with ERGIC-53, and a role for ERGIC-53 in the propagation of several highly pathogenic RNA virus families.

  5. Studies indicate that the LMAN1-CRD (show CRX Antibodies) contains distinct, separable binding sites for both its partner protein MCFD2 (show MCFD2 Antibodies) and the cargo proteins FV/FVIII (show F8 Antibodies).

  6. Data indicate that together with its soluble coreceptor MCFD2 (show MCFD2 Antibodies), LMAN1 transports coagulation factors V (FV) and VIII (show COX8A Antibodies) (FVIII (show F8 Antibodies)).

  7. Mutations in LMAN1 lead to F5F8D (combined deficiency of factor V And factor VIII) due to alterations in LMAN1-MCFD2 (show MCFD2 Antibodies) complex of coat protein (show GOLPH3 Antibodies) (COP (show CARD16 Antibodies))II complex trafficking machinery; 70% of F5F8D patients have mutations in LMAN1. [REVIEW]

  8. UBXD1 (show UBXN6 Antibodies) modulates the trafficking of ERGIC-53-containing vesicles by controlling the interaction of transport factors with the cytoplasmic tail of ERGIC-53.

  9. Two new mutations at ERGIC-53 gene in a Turkish family.

  10. Data present the crystal structure of the LMAN1/MCFD2 (show MCFD2 Antibodies) complex and relate it to patient mutations. Circular dichroism data show that the majority of the substitution mutations give rise to a disordered or severely destabilized MCFD2 (show MCFD2 Antibodies) protein.

Mouse (Murine) Lectin, Mannose-Binding, 1 (LMAN1) interaction partners

  1. LMAN1 may play a role in photoreceptor gene transport and homeostasis.

  2. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of alpha1-antitrypsin.

  3. surfactant proteins A and D and mannose-binding lectin (show MBL2 Antibodies) play roles in inflammation caused by DNA in lungs and other tissues

  4. ERGIC-53 gene transcription is regulated in response to endoplasmic reticulum stress

LMAN1 Antigen Profile

Protein Summary

The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.

Gene names and symbols associated with LMAN1

  • lectin, mannose binding 1 (LMAN1) antibody
  • lectin, mannose-binding, 1 (Lman1) antibody
  • complexin 3 (cplx3) antibody
  • lectin, mannose-binding, 1 (lman1) antibody
  • lectin, mannose binding 1 (lman1) antibody
  • lectin, mannose binding 1 S homeolog (lman1.S) antibody
  • lectin, mannose binding 1 (Lman1) antibody
  • 2610020P13Rik antibody
  • AI326273 antibody
  • AU043785 antibody
  • C730041J05 antibody
  • cpx-iii antibody
  • cpxiii antibody
  • ERGIC-53 antibody
  • ERGIC53 antibody
  • F5F8D antibody
  • FMFD1 antibody
  • gp58 antibody
  • lman1 antibody
  • lman1-a antibody
  • MCFD1 antibody
  • MR60 antibody
  • p58 antibody
  • wu:fc54c09 antibody
  • wu:fi36e01 antibody
  • Xp58 antibody

Protein level used designations for LMAN1

ER-Golgi intermediate compartment 53 kDa protein , endoplasmic reticulum-golgi intermediate compartment protein 53 , intracellular mannose specific lectin , intracellular mannose-specific lectin MR60 , protein ERGIC-53 , lectin, mannose-binding, 1 , lectin mannose-binding 1 , fc54c09 , fi36e01 , protein ERGIC-53-like , ERGIC-53 protein , intracellular mannose specific lectin MR60 , LOW QUALITY PROTEIN: protein ERGIC-53

GENE ID SPECIES
3998 Homo sapiens
70361 Mus musculus
116666 Rattus norvegicus
426849 Gallus gallus
455448 Pan troglodytes
476186 Canis lupus familiaris
496634 Xenopus (Silurana) tropicalis
559775 Danio rerio
697449 Macaca mulatta
100021881 Monodelphis domestica
100354112 Oryctolagus cuniculus
100404326 Callithrix jacchus
100475249 Ailuropoda melanoleuca
100562643 Anolis carolinensis
100592766 Nomascus leucogenys
394295 Xenopus laevis
511649 Bos taurus
100728262 Cavia porcellus
Selected quality suppliers for anti-LMAN1 (LMAN1) Antibodies
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