LMAN1 antibody (N-Term)

Catalog No. ABIN2782680

This Rabbit Polyclonal antibody specifically detects LMAN1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Cow, Horse, Pig, Rabbit, Zebrafish (Danio rerio) and Guinea Pig.

Quick Overview for LMAN1 antibody (N-Term) (ABIN2782680)

Target: LMAN1 (Lectin, Mannose-Binding, 1 (LMAN1))

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Pig, Rabbit, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LMAN1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LMAN1 Antibody

Binding Specificity: N-Term

Purpose: LMAN1 Antibody - N-terminal region

Sequence: DPAVALPHRR FEYKYSFKGP HLVQSDGTVP FWAHAGNAIP SSDQIRVAPS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against LMAN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LMAN1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46613-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for LMAN1

Target: LMAN1 (Lectin, Mannose-Binding, 1 (LMAN1))

Alternative Name: LMAN1

Background:

Background Information: LMAN1 is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in its gene are associated with a coagulation defect. Using positional cloning, its gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Lectin, mannose-binding, 1

Alternative Symbols: MR60, gp58, F5F8D, FMFD1, MCFD1, ERGIC53, ERGIC-53

Protein Name: Protein ERGIC-53

Molecular Weight: 54kDa

Gene ID: 3998

NCBI Accession: NP_005561

UniProt: P49257