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LEFTY1 encodes a member of the TGF-beta family of proteins. Additionally we are shipping Left-Right Determination Factor 1 Kits (25) and Left-Right Determination Factor 1 Proteins (17) and many more products for this protein.
Showing 10 out of 97 products:
Human Monoclonal LEFTY1 Primary Antibody for ELISA, WB - ABIN564640
Yamasaki, Kasai, Toi, Kurita, Kimoto, Hayata-Takano, Nakazawa, Nagayasu, Shintani, Hashimoto, Ito, Meltzer, Ago, Waschek, Onaka, Matsuda, Baba, Hashimoto et al.: Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-? (TGF-?) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic ... in Journal of neurochemistry 2015
Theauthors find that zebrafish lefty (show LEFTY2 Antibodies) mutants exhibit excess Nodal signaling and increased specification of mesendoderm, resulting in embryonic lethality.
Our data do not support the reaction-diffusion model, but instead, we propose that Nodal activates signaling in a temporal window that is defined by a miR (show MYLIP Antibodies)-430-mediated delay of Lft1/2 translation
results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty (show LEFTY2 Antibodies) range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning
both Nodal and Bmp independently are required for lefty1 expression to assure unilateral Nodal activation and correct LR patterning
Bmp represses Nodal signaling independently of lefty1 expression and through the activity of a ligand other than Bmp4 (show BMP4 Antibodies).
we find that Cyclops is specifically required for the maintenance of lefty1 and lefty2 (show LEFTY2 Antibodies) transcription
study reports that microRNA-430 (miR (show MYLIP Antibodies)-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta (show TGFB1 Antibodies) Nodal antagonist lefty (show LEFTY2 Antibodies)
A cell that experiences the highest level of Nodal signaling begins to express Lefty1 and becomes an L1(epi (show TFPI Antibodies)) cell. Deletion of Lefty1 alone or together with Lefty2 (show LEFTY2 Antibodies) increased the number of prospective DVE cells
Lefty1 may ameliorate renal tubulointerstitial inflammation by suppressing NFkappaB signaling.
results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty (show LEFTY2 Antibodies)-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (show DNMT3A Antibodies) and DNMT3B (show DNMT3B Antibodies); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (show HELLS Antibodies) and demethylation crucial to regulation of key signalling pathways in early body plan formation
exogenous lefty1 administered to mice restored the endogenous expression levels of lefty1. The present study demonstrated that lefty1 attenuated renal interstitial injury by inhibiting the Smaddependent TGFb1 (show TGFB1 Antibodies) signaling pathway
Lefty-1 may prevent TGFB1 (show TGFB1 Antibodies)-induced fibroblast-myofibroblast transdifferentiation in part via modulation of Smad3 (show SMAD3 Antibodies), JNK-3 (show MAPK10 Antibodies), and BMP-5 (show BMP5 Antibodies) signaling.
The expression of lefty (show LEFTY2 Antibodies) in RCC (show XRCC1 Antibodies) cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC (show XRCC1 Antibodies).
Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2 (show LEFTY2 Antibodies)) has a conserved role in left-right asymmetry.
Taken together, these results suggest that optimal expression of Lefty1 and Lefty2 (show LEFTY2 Antibodies) is critical for the balanced differentiation of mESCs into three germ layers.
Beta-catenin can recrui (show KDM1A Antibodies)t the H3K4me2/1 d (show CTNNB1 Antibodies)emethylase LSD1 to regulate the expression of the tumor suppressor Lefty1 in mouse embryonic stem cells.
Lefty (show LEFTY2 Antibodies) can antagonise TGF-beta1 (show TGFB1 Antibodies) mediated epithelial-mesenchymal transition in renal tubular epithelial cells.
functional role of LEFTY (show LEFTY2 Antibodies) during progesterone therapy for endometrial carcinoma
Studied genes involved in TGF-beta/BMP (show TGFb Antibodies) signaling pathway including chorionic villi LEFTY1 expression levels in association with miscarriage.
Lefty1 could regulates the cell cycle via modulating the expressions of P57 (show CDKN1C Antibodies) and cyclin D1 (show CCND1 Antibodies) and then inhibit the decidualization in vitro.
The mRNA levels of LSD1 (show KDM1A Antibodies) and beta-catenin (show CTNNB1 Antibodies) are inversely correlated with the levels of Lefty1 in pancreas and breast tumors.
Reprogrammed cancer cells share the mechanism for expression of Lefty (show LEFTY2 Antibodies) with induced pluripotent cancer cells (iPS (show SLC27A4 Antibodies)), thus contributing to the cancerous transformation of iPS (show SLC27A4 Antibodies) cells.
Data suggest that Lefty (show LEFTY2 Antibodies) is a novel TGF-beta (show TGFB1 Antibodies) target molecule that mediates growth inhibition of pancreatic cancer cells.
Findings suggest that Lefty1 is negatively modulated by miR (show MLXIP Antibodies)-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification.
The expression of Nodal in normal and malignant endometrial cells that lack Lefty (show LEFTY2 Antibodies) strongly supports an important role for this embryonic morphogen (show SHH Antibodies) in the tissue remodelling events that occur across the menstrual cycle and in tumourogenesis.
nodal and the inhibitors of Nodal signaling, lefty (show LEFTY2 Antibodies)-A and lefty (show LEFTY2 Antibodies)-B, are down-regulated very early upon differentiation of human embryonic stem cells
LEFTY (show LEFTY2 Antibodies) proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation.
This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.
signaling molecule lefty1
, left-right determination factor 1
, left-right determination, factor B
, left-right determination factor 1-like
, protein lefty-1
, stimulated by retinoic acid gene 3 protein
, transforming growth factor beta-4
, left-right determination factor B
, protein lefty-B