anti-Left-Right Determination Factor 2 (LEFTY2) Antibodies

LEFTY2 encodes a member of the TGF-beta family of proteins. Additionally we are shipping and LEFTY2 Kits (9) and many more products for this protein.

Gene Name	GeneID	UniProt
LEFTY2	7044	O00292
LEFTY2	13590	Q64280
LEFTY2	289316

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Top anti-LEFTY2 Antibodies at antibodies-online.com

Showing 10 out of 78 products:

Catalog No.	Reactivity	Host	Conjugate	Application	Quantity	Supplier	Delivery	Price	Details
ABIN2777146	Cow	Rabbit	Un-conjugated	IHC, WB	100 μL	Log in to see	2 to 3 Days	$289.00	Details
ABIN2777147	Dog	Rabbit	Un-conjugated	WB	100 μL	Log in to see	2 to 3 Days	$289.00	Details
ABIN5556648	Human	Mouse	Un-conjugated	EIA, IHC (p), WB	0.1 mg	Log in to see	8 to 11 Days	$619.30	Details
ABIN2855096	Human	Rabbit	Un-conjugated	IHC (p), WB	100 μL	Log in to see	1 to 2 Days	$358.60	Details
ABIN959060	Human	Rabbit	Un-conjugated	IHC, IHC (p), WB	50 μg	Log in to see	11 to 14 Days	$727.83	Details
ABIN337262	Human	Mouse	Un-conjugated	ELISA, IHC, IHC (p), WB	50 μg	Log in to see	11 to 14 Days	$484.00	Details
ABIN4904216	Human	Rabbit	Un-conjugated	WB	100 μL	Log in to see	16 Days	$334.77	Details
ABIN1176098	Human	Rabbit	Un-conjugated	ICC, IHC, WB	100 μg	Log in to see	15 to 18 Days	$350.00	Details
ABIN1176101	Mouse	Rabbit	Un-conjugated	ICC, IHC, WB	100 μg	Log in to see	15 to 18 Days	$360.00	Details
ABIN1176104	Rat	Rabbit	Un-conjugated	ICC, IHC, WB	100 μg	Log in to see	15 to 18 Days	$380.00	Details

More product categories related to LEFTY2 Antibody

More Antibodies against LEFTY2 Interaction Partners

Human Left-Right Determination Factor 2 (LEFTY2) interaction partners

LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage.
LEFTY2 down-regulates MKi67 (show MKI67 Antibodies) expression and FAK (show PTK2 Antibodies) activity, up-regulates miR (show MLXIP Antibodies)-200a and E-cadherin (show CDH1 Antibodies), and is thus a powerful negative regulator of endometrial cell proliferation and migration.
LEFTY2 regulates the expression and activity of ENaC (show SCNN1A Antibodies) in endometrial epithelial cells via SGK1 (show SGK1 Antibodies).
Lefty A may account for the tumor suppressive activity of human adult stem cells.
Findings suggest that Lefty2 is negatively modulated by miR (show MLXIP Antibodies)-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification.
findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression
nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells
Addition of recombinant LEFTY-A to explants induced MMP-9 (show MMP9 Antibodies) in most samples, a response prevented by ovarian steroids.
LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation.

Mouse (Murine) Left-Right Determination Factor 2 (LEFTY2) interaction partners

A cell that experiences the highest level of Nodal signaling begins to express Lefty1 (show LEFTY1 Antibodies) and becomes an L1(epi (show TFPI Antibodies)) cell. Deletion of Lefty1 (show LEFTY1 Antibodies) alone or together with Lefty2 increased the number of prospective DVE cells
Lefty1 may ameliorate renal tubulointerstitial inflammation by suppressing NFkappaB signaling.
results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (show DNMT3A Antibodies) and DNMT3B (show DNMT3B Antibodies); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (show HELLS Antibodies) and demethylation crucial to regulation of key signalling pathways in early body plan formation
LEFTY2 regulates the expression and activity of ENaC (show SCNN1A Antibodies) in endometrial epithelial cells via SGK1 (show SGK1 Antibodies).
Results indicate that microRNA miR (show MLXIP Antibodies)-127 accelerates mesendoderm differentiation of embryonic stem cells through nodal signaling by targeting left-right determination factor 2 (Lefty2).
exogenous lefty1 (show LEFTY1 Antibodies) administered to mice restored the endogenous expression levels of lefty1 (show LEFTY1 Antibodies). The present study demonstrated that lefty1 (show LEFTY1 Antibodies) attenuated renal interstitial injury by inhibiting the Smaddependent TGFb1 (show TGFB1 Antibodies) signaling pathway
Lefty-1 (show LEFTY1 Antibodies) may prevent TGFB1 (show TGFB1 Antibodies)-induced fibroblast-myofibroblast transdifferentiation in part via modulation of Smad3 (show SMAD3 Antibodies), JNK-3 (show MAPK10 Antibodies), and BMP-5 (show BMP5 Antibodies) signaling.
The expression of lefty in RCC (show XRCC1 Antibodies) cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC (show XRCC1 Antibodies).
Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2) has a conserved role in left-right asymmetry.
Taken together, these results suggest that optimal expression of Lefty1 (show LEFTY1 Antibodies) and Lefty2 is critical for the balanced differentiation of mESCs into three germ layers.

Zebrafish Left-Right Determination Factor 2 (LEFTY2) interaction partners

Theauthors find that zebrafish lefty mutants exhibit excess Nodal signaling and increased specification of mesendoderm, resulting in embryonic lethality.
results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning
we find that Cyclops is specifically required for the maintenance of lefty1 (show LEFTY1 Antibodies) and lefty2 transcription
study reports that microRNA-430 (miR (show MYLIP Antibodies)-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta (show TGFB1 Antibodies) Nodal antagonist lefty

LEFTY2 Antigen Profile

Protein Summary

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with LEFTY2

left-right determination factor 2 (LEFTY2) antibody
left right determination factor 1 (Lefty1) antibody
lefty2 (lft2) antibody
left-right determination factor 2 (Lefty2) antibody
Left-right determination factor 2 (Lefty2) antibody
left-right determination factor 2 (LOC699676) antibody
left-right determination factor 2-like (LOC100232580) antibody

6030463A22Rik antibody
AI450052 antibody
atv2 antibody
AV214969 antibody
cb720 antibody
Ebaf antibody
Ebaf2 antibody
fe38b03 antibody
Lefta antibody
Leftb antibody
lefty antibody
lefty-1 antibody
LEFTYA antibody
Stra3 antibody
Tgfb4 antibody
wu:fe38b03 antibody

Protein level used designations for LEFTY2

TGF-beta-4 , endometrial bleeding-associated factor , left-right determination factor A , protein lefty-2 , protein lefty-A , transforming growth factor beta-4 , left-right determination factor 1 , left-right determination, factor B , protein lefty-1 , stimulated by retinoic acid gene 3 protein , endometrial bleeding associated factor , left-right determination factor B , left-right determination, factor A , protein lefty-B , left-right determination factor 2 , lefty , left-right determination factor 2-like

GENE ID	SPECIES
7044	Homo sapiens
13590	Mus musculus
30146	Danio rerio
320202	Mus musculus
534018	Bos taurus
100337677	Sus scrofa
289316	Rattus norvegicus
395529	Gallus gallus
457780	Pan troglodytes
699676	Macaca mulatta
100232580	Taeniopygia guttata
100435327	Pongo abelii

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