anti-Left-Right Determination Factor 2 (LEFTY2) Antibodies

LEFTY2 encodes a member of the TGF-beta family of proteins.

list all antibodies Gene Name GeneID UniProt
Anti-Human LEFTY2 LEFTY2 7044 O00292
Anti-Mouse LEFTY2 LEFTY2 13590 Q64280
Anti-Rat LEFTY2 LEFTY2 289316  
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Top anti-LEFTY2 Antibodies at antibodies-online.com

Showing 10 out of 74 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-LEFTY2 Antibody Titration:  0.2-1 ug/ml  Positive Control:  RPMI 8226 cell lysate LEFTY2 is supported by BioGPS gene expression data to be expressed in RPMI 8226 Immunohistochemistry with Uterus tissue at an antibody concentration of 5µg/ml using anti-LEFTY2 antibody (ARP42107_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  LEFTY2  Sample Type:  Thymus Tumor lysates  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated EIA, IHC (p), WB   0.1 mg Log in to see 8 to 11 Days
$619.30
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: A431 , 10% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using LEFTY2, antibody at 1:500 dilution. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Anti-LEFTY2 antibody IHC staining of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959060 concentration 5 ug/ml. 50 μg Log in to see 7 to 9 Days
$727.83
Details
Human Mouse Un-conjugated ELISA, IHC, IHC (p), WB Human Uterus, Myometrium (formalin-fixed, paraffin-embedded) stained with LEFTY2 antibody ABIN337262 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cells, using LEFTY2 antibody. 100 μL Log in to see 16 Days
$334.02
Details
Human Rabbit Un-conjugated ICC, IHC, WB Used in DAB staining on fromalin fixed paraffin-embedded testis tissue 100 μg Log in to see 15 to 18 Days
$350.00
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Mouse Tissue 100 μg Log in to see 15 to 18 Days
$360.00
Details
Rat Rabbit Un-conjugated ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Rat Tissue 100 μg Log in to see 15 to 18 Days
$380.00
Details

More Antibodies against LEFTY2 Interaction Partners

Human Left-Right Determination Factor 2 (LEFTY2) interaction partners

  1. LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage.

  2. LEFTY2 down-regulates MKi67 (show MKI67 Antibodies) expression and FAK (show PTK2 Antibodies) activity, up-regulates miR (show MLXIP Antibodies)-200a and E-cadherin (show CDH1 Antibodies), and is thus a powerful negative regulator of endometrial cell proliferation and migration.

  3. LEFTY2 regulates the expression and activity of ENaC (show SCNN1A Antibodies) in endometrial epithelial cells via SGK1 (show SGK1 Antibodies).

  4. Lefty A may account for the tumor suppressive activity of human adult stem cells.

  5. Findings suggest that Lefty2 is negatively modulated by miR (show MLXIP Antibodies)-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification.

  6. findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression

  7. nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells

  8. Addition of recombinant LEFTY-A to explants induced MMP-9 (show MMP9 Antibodies) in most samples, a response prevented by ovarian steroids.

  9. LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation.

Mouse (Murine) Left-Right Determination Factor 2 (LEFTY2) interaction partners

  1. results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (show DNMT3A Antibodies) and DNMT3B (show DNMT3B Antibodies); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (show HELLS Antibodies) and demethylation crucial to regulation of key signalling pathways in early body plan formation

  2. LEFTY2 regulates the expression and activity of ENaC (show SCNN1A Antibodies) in endometrial epithelial cells via SGK1 (show SGK1 Antibodies).

  3. Results indicate that microRNA miR (show MLXIP Antibodies)-127 accelerates mesendoderm differentiation of embryonic stem cells through nodal signaling by targeting left-right determination factor 2 (Lefty2).

  4. exogenous lefty1 (show LEFTY1 Antibodies) administered to mice restored the endogenous expression levels of lefty1 (show LEFTY1 Antibodies). The present study demonstrated that lefty1 (show LEFTY1 Antibodies) attenuated renal interstitial injury by inhibiting the Smaddependent TGFb1 (show TGFB1 Antibodies) signaling pathway

  5. Lefty-1 (show LEFTY1 Antibodies) may prevent TGFB1 (show TGFB1 Antibodies)-induced fibroblast-myofibroblast transdifferentiation in part via modulation of Smad3 (show SMAD3 Antibodies), JNK-3 (show MAPK10 Antibodies), and BMP-5 (show BMP5 Antibodies) signaling.

  6. The expression of lefty in RCC (show XRCC1 Antibodies) cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC (show XRCC1 Antibodies).

  7. Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2) has a conserved role in left-right asymmetry.

  8. Taken together, these results suggest that optimal expression of Lefty1 (show LEFTY1 Antibodies) and Lefty2 is critical for the balanced differentiation of mESCs into three germ layers.

  9. Beta-catenin (show CTNNB1 Antibodies) can recruit the H3K4me2/1 demethylase (show MBD2 Antibodies) LSD1 (show KDM1A Antibodies) to regulate the expression of the tumor suppressor Lefty1 (show LEFTY1 Antibodies) in mouse embryonic stem cells.

  10. Lefty can antagonise TGF-beta1 (show TGFB1 Antibodies) mediated epithelial-mesenchymal transition in renal tubular epithelial cells.

Zebrafish Left-Right Determination Factor 2 (LEFTY2) interaction partners

  1. Theauthors find that zebrafish lefty mutants exhibit excess Nodal signaling and increased specification of mesendoderm, resulting in embryonic lethality.

  2. results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning

  3. we find that Cyclops is specifically required for the maintenance of lefty1 (show LEFTY1 Antibodies) and lefty2 transcription

  4. study reports that microRNA-430 (miR (show MYLIP Antibodies)-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta (show TGFB1 Antibodies) Nodal antagonist lefty

LEFTY2 Antigen Profile

Protein Summary

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with LEFTY2

  • left-right determination factor 2 (LEFTY2) antibody
  • left right determination factor 1 (Lefty1) antibody
  • lefty2 (lft2) antibody
  • left-right determination factor 2 (Lefty2) antibody
  • Left-right determination factor 2 (Lefty2) antibody
  • left-right determination factor 2 (LOC699676) antibody
  • left-right determination factor 2-like (LOC100232580) antibody
  • 6030463A22Rik antibody
  • AI450052 antibody
  • atv2 antibody
  • AV214969 antibody
  • cb720 antibody
  • Ebaf antibody
  • Ebaf2 antibody
  • fe38b03 antibody
  • Lefta antibody
  • Leftb antibody
  • lefty antibody
  • lefty-1 antibody
  • LEFTYA antibody
  • Stra3 antibody
  • Tgfb4 antibody
  • wu:fe38b03 antibody

Protein level used designations for LEFTY2

TGF-beta-4 , endometrial bleeding-associated factor , left-right determination factor A , protein lefty-2 , protein lefty-A , transforming growth factor beta-4 , left-right determination factor 1 , left-right determination, factor B , protein lefty-1 , stimulated by retinoic acid gene 3 protein , endometrial bleeding associated factor , left-right determination factor B , left-right determination, factor A , protein lefty-B , left-right determination factor 2 , lefty , left-right determination factor 2-like

GENE ID SPECIES
7044 Homo sapiens
13590 Mus musculus
30146 Danio rerio
320202 Mus musculus
534018 Bos taurus
100337677 Sus scrofa
289316 Rattus norvegicus
395529 Gallus gallus
457780 Pan troglodytes
699676 Macaca mulatta
100232580 Taeniopygia guttata
100435327 Pongo abelii
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