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LEFTY2 encodes a member of the TGF-beta family of proteins.
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LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage.
LEFTY2 down-regulates MKi67 (show MKI67 Antibodies) expression and FAK (show PTK2 Antibodies) activity, up-regulates miR (show MLXIP Antibodies)-200a and E-cadherin (show CDH1 Antibodies), and is thus a powerful negative regulator of endometrial cell proliferation and migration.
LEFTY2 regulates the expression and activity of ENaC (show SCNN1A Antibodies) in endometrial epithelial cells via SGK1 (show SGK1 Antibodies).
Lefty A may account for the tumor suppressive activity of human adult stem cells.
Findings suggest that Lefty2 is negatively modulated by miR (show MLXIP Antibodies)-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification.
findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression
nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells
Addition of recombinant LEFTY-A to explants induced MMP-9 (show MMP9 Antibodies) in most samples, a response prevented by ovarian steroids.
LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation.
results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (show DNMT3A Antibodies) and DNMT3B (show DNMT3B Antibodies); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (show HELLS Antibodies) and demethylation crucial to regulation of key signalling pathways in early body plan formation
Results indicate that microRNA miR (show MLXIP Antibodies)-127 accelerates mesendoderm differentiation of embryonic stem cells through nodal signaling by targeting left-right determination factor 2 (Lefty2).
exogenous lefty1 (show LEFTY1 Antibodies) administered to mice restored the endogenous expression levels of lefty1 (show LEFTY1 Antibodies). The present study demonstrated that lefty1 (show LEFTY1 Antibodies) attenuated renal interstitial injury by inhibiting the Smaddependent TGFb1 (show TGFB1 Antibodies) signaling pathway
Lefty-1 (show LEFTY1 Antibodies) may prevent TGFB1 (show TGFB1 Antibodies)-induced fibroblast-myofibroblast transdifferentiation in part via modulation of Smad3 (show SMAD3 Antibodies), JNK-3 (show MAPK10 Antibodies), and BMP-5 (show BMP5 Antibodies) signaling.
The expression of lefty in RCC (show XRCC1 Antibodies) cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC (show XRCC1 Antibodies).
Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2) has a conserved role in left-right asymmetry.
Taken together, these results suggest that optimal expression of Lefty1 (show LEFTY1 Antibodies) and Lefty2 is critical for the balanced differentiation of mESCs into three germ layers.
Beta-catenin (show CTNNB1 Antibodies) can recruit the H3K4me2/1 demethylase (show MBD2 Antibodies) LSD1 (show KDM1A Antibodies) to regulate the expression of the tumor suppressor Lefty1 (show LEFTY1 Antibodies) in mouse embryonic stem cells.
Lefty can antagonise TGF-beta1 (show TGFB1 Antibodies) mediated epithelial-mesenchymal transition in renal tubular epithelial cells.
Theauthors find that zebrafish lefty mutants exhibit excess Nodal signaling and increased specification of mesendoderm, resulting in embryonic lethality.
results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning
we find that Cyclops is specifically required for the maintenance of lefty1 (show LEFTY1 Antibodies) and lefty2 transcription
study reports that microRNA-430 (miR (show MYLIP Antibodies)-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta (show TGFB1 Antibodies) Nodal antagonist lefty
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.
, endometrial bleeding-associated factor
, left-right determination factor A
, protein lefty-2
, protein lefty-A
, transforming growth factor beta-4
, left-right determination factor 1
, left-right determination, factor B
, protein lefty-1
, stimulated by retinoic acid gene 3 protein
, endometrial bleeding associated factor
, left-right determination factor B
, left-right determination, factor A
, protein lefty-B
, left-right determination factor 2
, left-right determination factor 2-like