anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) Antibodies

Orphan receptor. Additionally we are shipping LGR5 Proteins (8) and LGR5 Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LGR5 14160 Q9Z1P4
LGR5 299802  
LGR5 8549 O75473
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Top anti-LGR5 Antibodies at antibodies-online.com

Showing 10 out of 211 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB LGR5/GPR49 Antibody (Loop2) (ABIN389218) western blot analysis in HepG2 cell line lysates (35 µg/lane).This demonstrates the LGR5/GPR49 antibody detected the LGR5/GPR49 protein (arrow)(Kindly offered by Dr. Li). Western blot analysis of anti-LGR5/GPR49 Antibody (loop2) (ABIN389218) in mouse cerebellum tissue lysates (35 µg/lane).LGR5/GPR49(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Mouse Un-conjugated FACS, IF, IP, IHC, WB Anti-LGR5 mouse monoclonal antibody ABIN2454875 immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LGR5 (RC212845). HEK293T cells were transfected with the empty vector control (Left lane) or Human LGR5 expression plasmid (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LGR5. 0.1 mL Log in to see Available
$482.90
Details
Human Rat Biotin BI, FACS, IF   50 μg Log in to see 15 to 18 Days
$325.09
Details
Human Rat Un-conjugated BI, FACS, IF, WB   0.1 mg Log in to see 15 to 18 Days
$255.44
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB LGR5/GPR49 Antibody (N-term) (ABIN389215) western blot analysis in HepG2 cell line lysates (35 µg/lane).This demonstrates the LGR5/GPR49 antibody detected the LGR5/GPR49 protein (arrow)(Kindly offered by Dr. Li). Formalin-fixed and paraffin-embedded human brain tissue reacted with LGR5/GPR49 antibody (N-term) (ABIN389215), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated IHC, IHC (fro), IHC (p), WB Immunohistochemistry-Frozen: Lgr5/GPR49 Antibody [NBP1-28904] - Staining on pig small intestine from a review by a confirmed customer. 0.1 mL Log in to see 7 to 9 Days
$514.63
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-GPR49/LGR5 Polyclonal Antibody, Unconjugated (ABIN737916) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded mouse colon carcinoma labeled with Anti-GPR49/LGR5 Polyclonal Antibody, Unconjugated (ABIN737916) at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
$318.45
Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ELISA, FACS, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 2:Western blot analysis using LGR5 mAb against human LGR5 (AA: 22-178) recombinant protein. (Expected MW is 43.4 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days
$561.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of anti-LGR5/GPR49 Antibody (Center) (ABIN389219) in K562 cell line lysates (35 µg/lane). LGR5/GPR49(arrow) was detected using the purified polyclonal antibody (1:60dilution). Formalin-fixed and paraffin-embedded human brain tissue reacted with LGR5/GPR49 antibody (Center) (ABIN389219), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$335.50
Details

Top referenced anti-LGR5 Antibodies

  1. Human Polyclonal LGR5 Primary Antibody for FACS, IF - ABIN389218 : Barker, van Es, Kuipers, Kujala, van den Born, Cozijnsen, Haegebarth, Korving, Begthel, Peters, Clevers: Identification of stem cells in small intestine and colon by marker gene Lgr5. in Nature 2007 (PubMed)
    Show all 11 Pubmed References

  2. Human Monoclonal LGR5 Primary Antibody for BI, FACS - ABIN2689805 : Barker, Huch, Kujala, van de Wetering, Snippert, van Es, Sato, Stange, Begthel, van den Born, Danenberg, van den Brink, Korving, Abo, Peters, Wright, Poulsom, Clevers: Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. in Cell stem cell 2010 (PubMed)
    Show all 8 Pubmed References

  3. Human Monoclonal LGR5 Primary Antibody for BI, FACS - ABIN2689804 : Carmon, Gong, Lin, Thomas, Liu: R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed)
    Show all 7 Pubmed References

  4. Human Monoclonal LGR5 Primary Antibody for FACS, IF - ABIN2724692 : Wu, Xie, Gao, Wang, Guo, Tian, Li, Fan: Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers. in Gene 2013 (PubMed)
    Show all 7 Pubmed References

  5. Human Polyclonal LGR5 Primary Antibody for IHC, IHC (fro) - ABIN440586 : Jung, Saif: Porcine epidemic diarrhea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxis. in Veterinary journal (London, England : 1997) 2015 (PubMed)
    Show all 4 Pubmed References

  6. Human Polyclonal LGR5 Primary Antibody for FACS, IF - ABIN389215 : Kanwar, Yu, Nautiyal, Patel, Majumdar: The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. in Molecular cancer 2010 (PubMed)
    Show all 5 Pubmed References

  7. Human Polyclonal LGR5 Primary Antibody for FACS, IHC (p) - ABIN389219 : Walker, Zhang, Odorizzi, Burgess: LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines. in PLoS ONE 2011 (PubMed)
    Show all 3 Pubmed References

  8. Human Polyclonal LGR5 Primary Antibody for IF (p), IHC (p) - ABIN737916 : Su, Li, Liu, Ren, Tian, Liu, Qiu: Ionizing radiation promotes advanced malignant traits in nasopharyngeal carcinoma via activation of epithelial-mesenchymal transition and the cancer stem cell phenotype. in Oncology reports 2016 (PubMed)

  9. Human Monoclonal LGR5 Primary Antibody for Agon, CyTOF - ABIN5012945 : Chiou, Yang, Huang, Tang, Yen, Tsai, Chen, Fadhilah, Lin, Jong: Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells. in Scientific reports 2017 (PubMed)

  10. Human Monoclonal LGR5 Primary Antibody for FACS - ABIN4895691 : Arioka, Ito, Hirata, Semi, Yamada, Seishima: Behavior of leucine-rich repeat-containing G-protein coupled receptor 5-expressing cells in the reprogramming process. in Stem cell research 2017 (PubMed)

More Antibodies against LGR5 Interaction Partners

Mouse (Murine) Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) interaction partners

  1. LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancer.

  2. Results show that Lgr5 is expressed at the neuromuscular junction (NMJ) and is a receptor for Rspo2 (show RSPO2 Antibodies).

  3. Mex3a (show MEX3A Antibodies) defines a reserve-like intestinal stem cell population within the Lgr5+ compartment.

  4. sorted Reg4 (show REG4 Antibodies)(+) DCS cells promote organoid formation of single Lgr5(+) colon stem cells. DCS cells can be massively produced from Lgr5(+) colon stem cells in vitro by combined Notch (show NOTCH1 Antibodies) inhibition and Wnt (show WNT2 Antibodies) activation

  5. The Lgr5-expressing cells differentiate into hair cells in high yield.

  6. Single-cell transcript profiles reveal multilineage priming in early progenitors derived from Lgr5-expressing intestinal stem cells.

  7. Arrb1 (show ARRB1 Antibodies) reduced the chemotherapy-induced Lgr5 stem cell apoptosis by inhibiting endoplasmic reticulum stress-mediated mitochondrial apoptotic signaling.

  8. demonstrates that Lgr5 cells give rise to both anterior and posterior taste buds during development, and are capable of regenerating posterior taste buds after injury induced by glossopharyngeal nerve transection

  9. Lgr5(+) chief cells are involved in maintaining the homeostatic stem cell pool. Define Lgr5(+) chief cells as a major cell-of-origin of gastric cancer.

  10. Stem cell plasticity enables hair regeneration following Lgr5(+) cell loss.

Human Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) interaction partners

  1. LGR5 overexpression was associated with high T stage and LN metastasis status in breast cancer. High LGR5 expression was also associated with reduced relapse-free survival, indicating that LGR5 may represent a promising prognostic marker for breast cancer patients.

  2. LGR5 is a critical effector of DDX1 (show DDX1 Antibodies) in colorectal cancer cells.

  3. Logarithmic expansion of LGR5-expressing cells was observed in human colorectal cancer.

  4. Findings suggest a tumor suppressor role for miR (show MLXIP Antibodies)-216a in gliomas, which inhibits glioma cell proliferation, migration, and invasion by targeting LGR5.

  5. LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancer.

  6. LGR5 expression in the epithelium and stroma was associated with tumor stage, and by integrating functional experiments with LGR5-sorted cell RNA sequencing data from adenoma and normal organoids, there were correlations between LGR5 and CRC (show CALR Antibodies)-specific genes, including dickkopf (show DKK1 Antibodies) WNT (show WNT2 Antibodies) signaling pathway inhibitor 4 (DKK4 (show DKK4 Antibodies)) and SPARC-related modular calcium binding 2 (SMOC2 (show SMOC2 Antibodies)

  7. LGR5 expression is transiently upregulated during the early stage of cardiomyocyte differentiation from hPSCs, and although LGR5 expression is not required for maintaining hPSCs in the undifferentiated state, knockdown of LGR5 leads to decreased expression of key cardiac transcription factors at the early stage with eventual lack of robust beating cardiomyocytes at the late stage.

  8. Lgr5 plays important roles in angiogenesis. Lgr5-specific siRNA could be designed into an effective therapeutic agent to inhibit gastric cancer angiogenesis.

  9. A regulatory mechanism of LGR5 expression in gastric carcinogenesis, with SP1 (show PSG1 Antibodies) as an important component of the transcriptional complex and LGR5 activity, which is modulated by its ligands RSPO1 (show RSPO1 Antibodies) and RSPO2 (show RSPO2 Antibodies), whose expression is modulated by methylation.

  10. these results demonstrate that Lgr5 activation of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling is a potential mechanism to promote the progression of ESCC and ESCC stem cell renewal, and Lgr5 may be used as a molecular target for the development of treatments for ESCC.

LGR5 Antigen Profile

Protein Summary

Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling.

Gene names and symbols associated with LGR5

  • leucine-rich repeat containing G protein-coupled receptor 5 L homeolog (lgr5.L) antibody
  • leucine rich repeat containing G protein coupled receptor 5 (Lgr5) antibody
  • leucine rich repeat containing G protein-coupled receptor 5 (LGR5) antibody
  • FEX antibody
  • GPR49 antibody
  • GPR67 antibody
  • GRP49 antibody
  • HG38 antibody
  • lgr5-a antibody
  • lgr5a antibody

Protein level used designations for LGR5

leucine-rich repeat-containing G protein-coupled receptor 5 , leucine-rich repeat-containing G-protein coupled receptor 5A , leucine-rich repeat-containing G-protein coupled receptor 5a , G protein-coupled receptor 49 , G-protein coupled receptor 49 , follicle expressed hormone , leucine-rich repeat-containing G-protein coupled receptor 5 , orphan G-protein coupled receptor FEX , G-protein coupled receptor 67 , G-protein coupled receptor HG38 , orphan G protein-coupled receptor HG38

GENE ID SPECIES
100526795 Xenopus laevis
14160 Mus musculus
299802 Rattus norvegicus
8549 Homo sapiens
427867 Gallus gallus
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