Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

LGR5 antibody (AA 605-638)

LGR5 Reactivity: Human IHC, ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031605
$578.58
Plus shipping costs $45.00
Shipping to: United States
Delivery in 2 to 3 Business Days
  • Target See all LGR5 Antibodies
    LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))
    Binding Specificity
    • 16
    • 15
    • 11
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 605-638
    Reactivity
    • 103
    • 58
    • 49
    • 1
    • 1
    Human
    Host
    • 92
    • 12
    Rabbit
    Clonality
    • 82
    • 22
    Polyclonal
    Conjugate
    • 48
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LGR5 antibody is un-conjugated
    Application
    • 51
    • 38
    • 27
    • 26
    • 20
    • 18
    • 16
    • 16
    • 8
    • 7
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Purification
    Purified
    Immunogen
    A portion of amino acids 605-638 from the human protein was used as the immunogen for this anti-LGR5 antibody.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the anti-LGR5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:10-1:50,Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the anti-LGR5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))
    Alternative Name
    LGR5 (LGR5 Products)
    Synonyms
    lgr5-a antibody, lgr5a antibody, FEX antibody, Gpr49 antibody, GPR49 antibody, GPR67 antibody, GRP49 antibody, HG38 antibody, leucine-rich repeat containing G protein-coupled receptor 5 L homeolog antibody, leucine rich repeat containing G protein coupled receptor 5 antibody, leucine rich repeat containing G protein-coupled receptor 5 antibody, lgr5.L antibody, Lgr5 antibody, LGR5 antibody
    Background
    LGR5/GPR49 is a receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. [UniProt]
    UniProt
    O75473
    Pathways
    WNT Signaling
You are here:
Support