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Orphan receptor. Additionally we are shipping LGR5 Antibodies (231) and LGR5 Kits (6) and many more products for this protein.
Showing 6 out of 8 products:
LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancer.
Results show that Lgr5 is expressed at the neuromuscular junction (NMJ) and is a receptor for Rspo2 (show RSPO2 Proteins).
Mex3a defines a reserve-like intestinal stem cell population within the Lgr5+ compartment.
sorted Reg4 (show REG4 Proteins)(+) DCS cells promote organoid formation of single Lgr5(+) colon stem cells. DCS cells can be massively produced from Lgr5(+) colon stem cells in vitro by combined Notch (show NOTCH1 Proteins) inhibition and Wnt (show WNT2 Proteins) activation
The Lgr5-expressing cells differentiate into hair cells in high yield.
Single-cell transcript profiles reveal multilineage priming in early progenitors derived from Lgr5-expressing intestinal stem cells.
Arrb1 (show ARRB1 Proteins) reduced the chemotherapy-induced Lgr5 stem cell apoptosis by inhibiting endoplasmic reticulum stress-mediated mitochondrial apoptotic signaling.
demonstrates that Lgr5 cells give rise to both anterior and posterior taste buds during development, and are capable of regenerating posterior taste buds after injury induced by glossopharyngeal nerve transection
Lgr5(+) chief cells are involved in maintaining the homeostatic stem cell pool. Define Lgr5(+) chief cells as a major cell-of-origin of gastric cancer.
Stem cell plasticity enables hair regeneration following Lgr5(+) cell loss.
Logarithmic expansion of LGR5-expressing cells was observed in human colorectal cancer.
Findings suggest a tumor suppressor role for miR (show MLXIP Proteins)-216a in gliomas, which inhibits glioma cell proliferation, migration, and invasion by targeting LGR5.
LGR5 expression in the epithelium and stroma was associated with tumor stage, and by integrating functional experiments with LGR5-sorted cell RNA sequencing data from adenoma and normal organoids, there were correlations between LGR5 and CRC (show CALR Proteins)-specific genes, including dickkopf (show DKK1 Proteins) WNT (show WNT2 Proteins) signaling pathway inhibitor 4 (DKK4 (show DKK4 Proteins)) and SPARC-related modular calcium binding 2 (SMOC2 (show SMOC2 Proteins)
LGR5 expression is transiently upregulated during the early stage of cardiomyocyte differentiation from hPSCs, and although LGR5 expression is not required for maintaining hPSCs in the undifferentiated state, knockdown of LGR5 leads to decreased expression of key cardiac transcription factors at the early stage with eventual lack of robust beating cardiomyocytes at the late stage.
Lgr5 plays important roles in angiogenesis. Lgr5-specific siRNA could be designed into an effective therapeutic agent to inhibit gastric cancer angiogenesis.
A regulatory mechanism of LGR5 expression in gastric carcinogenesis, with SP1 (show PSG1 Proteins) as an important component of the transcriptional complex and LGR5 activity, which is modulated by its ligands RSPO1 (show RSPO1 Proteins) and RSPO2 (show RSPO2 Proteins), whose expression is modulated by methylation.
these results demonstrate that Lgr5 activation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling is a potential mechanism to promote the progression of ESCC and ESCC stem cell renewal, and Lgr5 may be used as a molecular target for the development of treatments for ESCC.
Co-expression of Lgr5 and CXCR4 (show CXCR4 Proteins) characterizes cancer stem-like cells of colorectal cancer.
This study uncovers a novel cross-talk between LGR5 and TGFbeta (show TGFB1 Proteins) signaling in colon cancer and identifies LGR5 as a new modulator of TGFbeta (show TGFB1 Proteins) signaling able to suppress colon cancer metastasis.
Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling.
leucine-rich repeat-containing G protein-coupled receptor 5
, leucine-rich repeat-containing G-protein coupled receptor 5A
, leucine-rich repeat-containing G-protein coupled receptor 5a
, G protein-coupled receptor 49
, G-protein coupled receptor 49
, follicle expressed hormone
, leucine-rich repeat-containing G-protein coupled receptor 5
, orphan G-protein coupled receptor FEX
, G-protein coupled receptor 67
, G-protein coupled receptor HG38
, orphan G protein-coupled receptor HG38