Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 Proteins (LGR5)

Orphan receptor. Additionally we are shipping LGR5 Antibodies (231) and LGR5 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LGR5 14160 Q9Z1P4
Rat LGR5 LGR5 299802  
LGR5 8549 O75473
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Top LGR5 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
$7,639.51
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Yeast Human His tag   100 μg Log in to see 8 to 11 Days
$484.00
Details
HEK-293 Cells Human Fc Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days
$560.00
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$540.11
Details

LGR5 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
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Human , , ,
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More Proteins for Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) Interaction Partners

Mouse (Murine) Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) interaction partners

  1. LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancer.

  2. Results show that Lgr5 is expressed at the neuromuscular junction (NMJ) and is a receptor for Rspo2 (show RSPO2 Proteins).

  3. Mex3a defines a reserve-like intestinal stem cell population within the Lgr5+ compartment.

  4. sorted Reg4 (show REG4 Proteins)(+) DCS cells promote organoid formation of single Lgr5(+) colon stem cells. DCS cells can be massively produced from Lgr5(+) colon stem cells in vitro by combined Notch (show NOTCH1 Proteins) inhibition and Wnt (show WNT2 Proteins) activation

  5. The Lgr5-expressing cells differentiate into hair cells in high yield.

  6. Single-cell transcript profiles reveal multilineage priming in early progenitors derived from Lgr5-expressing intestinal stem cells.

  7. Arrb1 (show ARRB1 Proteins) reduced the chemotherapy-induced Lgr5 stem cell apoptosis by inhibiting endoplasmic reticulum stress-mediated mitochondrial apoptotic signaling.

  8. demonstrates that Lgr5 cells give rise to both anterior and posterior taste buds during development, and are capable of regenerating posterior taste buds after injury induced by glossopharyngeal nerve transection

  9. Lgr5(+) chief cells are involved in maintaining the homeostatic stem cell pool. Define Lgr5(+) chief cells as a major cell-of-origin of gastric cancer.

  10. Stem cell plasticity enables hair regeneration following Lgr5(+) cell loss.

Human Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) interaction partners

  1. Logarithmic expansion of LGR5-expressing cells was observed in human colorectal cancer.

  2. Findings suggest a tumor suppressor role for miR (show MLXIP Proteins)-216a in gliomas, which inhibits glioma cell proliferation, migration, and invasion by targeting LGR5.

  3. LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancer.

  4. LGR5 expression in the epithelium and stroma was associated with tumor stage, and by integrating functional experiments with LGR5-sorted cell RNA sequencing data from adenoma and normal organoids, there were correlations between LGR5 and CRC (show CALR Proteins)-specific genes, including dickkopf (show DKK1 Proteins) WNT (show WNT2 Proteins) signaling pathway inhibitor 4 (DKK4 (show DKK4 Proteins)) and SPARC-related modular calcium binding 2 (SMOC2 (show SMOC2 Proteins)

  5. LGR5 expression is transiently upregulated during the early stage of cardiomyocyte differentiation from hPSCs, and although LGR5 expression is not required for maintaining hPSCs in the undifferentiated state, knockdown of LGR5 leads to decreased expression of key cardiac transcription factors at the early stage with eventual lack of robust beating cardiomyocytes at the late stage.

  6. Lgr5 plays important roles in angiogenesis. Lgr5-specific siRNA could be designed into an effective therapeutic agent to inhibit gastric cancer angiogenesis.

  7. A regulatory mechanism of LGR5 expression in gastric carcinogenesis, with SP1 (show PSG1 Proteins) as an important component of the transcriptional complex and LGR5 activity, which is modulated by its ligands RSPO1 (show RSPO1 Proteins) and RSPO2 (show RSPO2 Proteins), whose expression is modulated by methylation.

  8. these results demonstrate that Lgr5 activation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling is a potential mechanism to promote the progression of ESCC and ESCC stem cell renewal, and Lgr5 may be used as a molecular target for the development of treatments for ESCC.

  9. Co-expression of Lgr5 and CXCR4 (show CXCR4 Proteins) characterizes cancer stem-like cells of colorectal cancer.

  10. This study uncovers a novel cross-talk between LGR5 and TGFbeta (show TGFB1 Proteins) signaling in colon cancer and identifies LGR5 as a new modulator of TGFbeta (show TGFB1 Proteins) signaling able to suppress colon cancer metastasis.

LGR5 Protein Profile

Protein Summary

Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling.

Gene names and symbols associated with LGR5

  • leucine-rich repeat containing G protein-coupled receptor 5 L homeolog (lgr5.L)
  • leucine rich repeat containing G protein coupled receptor 5 (Lgr5)
  • leucine rich repeat containing G protein-coupled receptor 5 (LGR5)
  • FEX protein
  • GPR49 protein
  • GPR67 protein
  • GRP49 protein
  • HG38 protein
  • lgr5-a protein
  • lgr5a protein

Protein level used designations for LGR5

leucine-rich repeat-containing G protein-coupled receptor 5 , leucine-rich repeat-containing G-protein coupled receptor 5A , leucine-rich repeat-containing G-protein coupled receptor 5a , G protein-coupled receptor 49 , G-protein coupled receptor 49 , follicle expressed hormone , leucine-rich repeat-containing G-protein coupled receptor 5 , orphan G-protein coupled receptor FEX , G-protein coupled receptor 67 , G-protein coupled receptor HG38 , orphan G protein-coupled receptor HG38

GENE ID SPECIES
100526795 Xenopus laevis
14160 Mus musculus
299802 Rattus norvegicus
8549 Homo sapiens
427867 Gallus gallus
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