LGR5 Protein (AA 22-561) (His tag)
Quick Overview for LGR5 Protein (AA 22-561) (His tag) (ABIN7013659)
Target
See all LGR5 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 22-561
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Purification tag / Conjugate
- This LGR5 protein is labelled with His tag.
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Characteristics
- Human LGR5 / GPR49 protein, His Tag
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) (AA 22-543) (Active) protein (hFc Tag)
LGR5 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE Active
Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) protein (DYKDDDDK Tag)LGR5 Origin: Human Host: HEK-293 Cells Synthetic Nanodisc Imm, ELISA, cryo-EM, PhD, SPR
Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) (AA 22-561) protein (His tag)LGR5 Origin: Human Host: Yeast Recombinant > 90 % SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Storage
- -20 °C
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- LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))
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Alternative Name
- LGR5
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Background
- LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs. LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt/β-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.
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Molecular Weight
- 62.0 kDa
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NCBI Accession
- NP_003658
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Pathways
- WNT Signaling
Target
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