Leukocyte Cell-Derived Chemotaxin 2 Proteins (LECT2)

LECT2 encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. Additionally we are shipping LECT2 Antibodies (77) and LECT2 Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LECT2 361205  
LECT2 3950 O14960
LECT2 16841 O88803
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Top LECT2 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$714.00
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$219.36
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 2 to 3 Days
$814.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,277.00
Details
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
$2,806.83
Details
Escherichia coli (E. coli) Mouse T7 tag,His tag 100 μg Log in to see 15 to 18 Days
$704.00
Details
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

LECT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , , ,
, ,
Mouse (Murine) ,
,

Top referenced LECT2 Proteins

  1. Human LECT2 Protein expressed in HEK-293 Cells - ABIN2724608 : Hwang, Jung, Hong, Seo, Kim, Kim, Choi, Choi, Baik, Yoo: LECT2 induces atherosclerotic inflammatory reaction via CD209 receptor-mediated JNK phosphorylation in human endothelial cells. in Metabolism: clinical and experimental 2015 (PubMed)

More Proteins for Leukocyte Cell-Derived Chemotaxin 2 (LECT2) Interaction Partners

Human Leukocyte Cell-Derived Chemotaxin 2 (LECT2) interaction partners

  1. Overexpression of LECT2 or treatment with a recombinant LECT2 protein impaired the colony-forming ability and motility of non-small cell lung cancer cells harboring high levels of activated EGFR and MET.

  2. Circulating LECT2 concentrations were increased in individuals with NAFLD and those with MetS, but not in those with atherosclerosis. The relationship between LECT2 and both NAFLD and MetS might be mediated by its association with abdominal obesity and lipid metabolism.

  3. VFA was the strongest predictor of plasma LECT2 that is a potential biomarker linking visceral obesity to dyslipidemia

  4. LECT2 was found to be catalytically inactive as a metalloendopeptidase against various types of peptide sequences, including pentaglycine.

  5. the tissue levels of THBS2 and LECT-2 may correlate with the stage of atherosclerosis.

  6. findings indicated that serum LECT2 level is negatively associated with the presence of diabetic retinopathy and suggest that low circulating LECT2 level is a risk factor for diabetic retinopathy

  7. LECT2 amyloidosis is prevalent among Hispanic decedents in New Mexico.

  8. ALECT2, which was initially thought to affect mainly Hispanics in the United States, appears to represent an important and likely underrecognized etiology of chronic kidney disease among Egyptians and probably in other ethnic groups around the world

  9. Localized LECT2 amyloidosis of the adrenal gland with coexisting MGUS: a diagnostic challenge.

  10. LECT2 immunostain is useful in confirming subtype of amyloid within the liver in ALECT2..

  11. Amyloidosis derived from leukocyte chemotactic factor 2 (ALECT2) is a recently described disease. Here, we report the characteristics and outcome of 72 patients with renal ALECT2, which included 19 who had another kidney disease on biopsy.

  12. There were no mutations detected in the LECT2 gene, although all renal leukocyte chemotactic factor 2 amyloidosis patients tested were homozygous for the G nucleotide in a non-synonymous SNP at position 172.

  13. LECT2 is regulated by beta-catenin in HCC in both mice and men, but serum LECT2 reflects beta-catenin activity only in mice. Serum LECT2 could be a potential biomarker of HCC in patients.

  14. First Nations people from British Columbia who presented with chronic kidney disease, were found to be due to LECT2 amyloidosis.

  15. The study indicates that serum LECT2 levels are increased by obesity and fatty liver, and suggests that LECT2 is a novel obesity-related protein.

  16. The data from this study show that weak LECT2 staining should be regarded as indeterminate or a negative result and does not per se allow diagnosis of specific amyloid type. The diagnosis of LECT2 renal amyloidosis may require LMD/MS confirmation.

  17. These results demonstrate the involvement of LECT2 in glucose metabolism and suggest that LECT2 may be a therapeutic target for obesity-associated insulin resistance.

  18. ALect2 is a common cause of hepatic amyloidosis in the population of the United States, and subtyping hepatic amyloid deposits by an accurate analytic method such as MS is required for optimal clinical management of hepatic amyloidosis patients

  19. These findings reveal a novel, specific inhibitory function of LECT2 in hepatocellular carcinoma by the direct binding and inactivation of MET.

  20. preliminary X-ray analysis of human leukocyte cell-derived chemotaxin 2 (LECT2).

Mouse (Murine) Leukocyte Cell-Derived Chemotaxin 2 (LECT2) interaction partners

  1. This study demonstrates the rapid response of LECT2 preceding body weight alterations during weight cycling in mice.

  2. We found that treatment with LECT2 enhanced H. pylori killing and nitric oxide production in macrophages. In addition, DNA-binding activity and nuclear translocation of p65 were up-regulated by LECT2 treatment

  3. LECT2 is regulated by beta-catenin in HCC in both mice and men, but serum LECT2 reflects beta-catenin activity only in mice. Serum LECT2 could be a potential biomarker of HCC in patients.

  4. LECT2 improves protective immunity in bacterial sepsis, possibly as a result of enhanced macrophages functions via the CD209a receptor.

  5. Zinc stabilizes the LECT2 structure.

  6. Data suggest the involvement of LECT2 in the regulation of fatal SEA-induced toxicity in d-GalN-sensitized mice.

  7. Our results suggest that LECT2 regulates neuritic extension through microtubular morphallaxis through the control of katanin-P60 levels.

  8. Our results show that LECT2 regulates the extension of axons and dendrites and the expressions of NGF, BDNF and NT-3 during neuronal development.

  9. LECT2, which encodes a protein with chemotactic properties for human neutrophils, is a direct target gene of Wnt/beta-catenin signaling in the liver.

  10. Triggers the early events of liver regeneration with concomitant suppression of hepatocyte proliferation.

  11. LECT2 directly suppresses the development of collagen antibody induced arthritis

LECT2 Protein Profile

Protein Summary

This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis.

Gene names and symbols associated with LECT2

  • leukocyte cell-derived chemotaxin 2 (Lect2)
  • leukocyte cell derived chemotaxin 2 (LECT2)
  • chm-II protein
  • chm2 protein
  • MIM1 protein

Protein level used designations for LECT2

chondromodulin-II , leukocyte cell-derived chemotaxin-2 , LECT-2 , chM-II , chondromodulin II , bChM-II , bLECT2 , cell-derived chemotaxin 2 , myeloid protein (mim-1) , myeloid protein 1 , p33

GENE ID SPECIES
361205 Rattus norvegicus
3950 Homo sapiens
16841 Mus musculus
281899 Bos taurus
474687 Canis lupus familiaris
396471 Gallus gallus
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