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The protein encoded by LST1 is a membrane protein that can inhibit the proliferation of lymphocytes. Additionally we are shipping LST1 Antibodies (62) and LST1 Proteins (4) and many more products for this protein.
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Increased expression of LST1 in GC-responders before therapy warrants further investigation into their role as potential predictors for the response to GC, and in the inflammatory process of rheumatoid arthritis.
Data indicate that the MHC (show HLAE ELISA Kits) class III gene LST1 5' untranslated regions (5'-UTR (show UTS2R ELISA Kits)) contains several upstream open reading frames (uORFs).
Psoriasis was associated with promoter variant, rs9267502 of LST1.Promoter activity was examined and it was larger than that of the other genetic variants, most probably due to changes in binding affinity to transcription factors.
This is the first report demonstrating regulated LST1 expression in human intestinal epithelial and microvascular endothelial cells and in inflamed colonic tissue from IBD patients.
LST1 is expressed specifically in leukocytes of the myeloid lineage, where it localizes to the tetraspanin-enriched microdomains andit binds SHP-1 and SHP-2 phosphatases.
Study found association between extended LTA (show LTA ELISA Kits), TNF (show TNF ELISA Kits), LST1 and HLA gene haplotypes and rubella vaccine-induced immunity.
Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 (show NCR3 ELISA Kits) receptor by activated NK cells.
Expression of this receptor, inhibited by TGF-beta1 (show TGFB1 ELISA Kits), affects NK-mediated killing of dendritic cells
The expression of LST1, specifically splice variants encoding soluble isoforms and NCR3 (show NCR3 ELISA Kits), was increased in rheumatoid-arthritis-affected blood and synovium and was associated with more severe inflammation in the synovium.
LST1 protein expression in human cell lines was found to be tightly regulated, allowing the expression of transmembrane isoforms but suppressing soluble isoforms
The absence of Lst1 leads to a slightly more susceptible phenotype. However, deletion of Lst1 in DBA (show RPS19 ELISA Kits)/2 J mice alone does not explain the high susceptibility of this strain to PR8M influenza infections.
The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene.
leukocyte-specific transcript 1 protein
, lymphocyte antigen 117
, leucocyte specific transcript 1