anti-Limbic System-Associated Membrane Protein (LSAMP) Antibodies

Human Limbic System-Associated Membrane Protein (LSAMP) interaction partners

1. We detected African-specific SNPs at ZNF649 (show ZNF649 Antibodies) and LSAMP, with associations of genome-wide significance for ulcerative colitis.

2. A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men

3. The results showed significant allelic and haplotypic associations between LSAMP gene and schizophrenia.

4. The tumor suppressor function of LSAMP is most likely exerted by reducing the proliferation rate of the tumor cells, possibly by indirectly upregulating one or more of the genes HES1 (show HES1 Antibodies), CTAG2 (show CTAG2 Antibodies) or KLF10 (show KLF10 Antibodies).

5. This study presents the first evidence of a possible role of LSAMP gene in mood and anxiety disorders in humans.

6. proteomic assessments of membrane microdomains in prefrontal cortex and validation in two brain series, strongly implicates LAMP, STXBP1 (show STXBP1 Antibodies) and BASP1 (show BASP1 Antibodies) in schizophreina and supports the view of a neuritic and synaptic dysfunction in the neuropathology

7. Single nucleotide polymorphisms of LSAMP is associated with the pathogenesis of coronary artery disease.

8. LSAMP might play a role in pathoaetiology of suicidal behaviour but further studies are needed to understand its exact contribution

9. results show that LSAMP is a novel candidate tumor suppressor gene in osteosarcomas

10. Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma.

Mouse (Murine) Limbic System-Associated Membrane Protein (LSAMP) interaction partners

1. Limbic system-associated membrane protein is involved in emotional and social operating systems by complex regulation of two alternative promoters.

2. Lsamp(-/-) mice are a promising model to study the neurobiological mechanisms of deviant social behaviour and adaptation impairment observed in many psychiatric disorders.

3. Lsamp-deficient mice were less sensitive to isolation stress than their wild-type littermates.

4. lsamp knockout mice have a deficit in spatial memory acquisition and poorly sustained CA1 (show CA1 Antibodies) long-term potentiation.

5. genomic features of the Lsamp gene indicate an intricate mechanism of gene expression regulation that may be relevant in the context of human neuropsychiatric and neurological disorders, where LAMP expression may be altered

6. Genetic deletion of Lsamp causes exaggerated behavioral activation in novel environments.