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LIPF encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. Additionally we are shipping LIPF Kits (32) and LIPF Proteins (12) and many more products for this protein.
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Human Polyclonal LIPF Primary Antibody for ELISA - ABIN547729
Ruaño, Windemuth, Kocherla, Holford, Fernandez, Forsythe, Wood, Kraemer, Volek: Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction. in Nutrition & metabolism 2006
site-directed mutagenesis the role of three key residues (K4, E225, R229) involved in salt bridges stabilizing the lid domain that controls the access to the active site and is part of the interfacial recognition site. Their substitution has an impact on the pH-dependent activity of rHGL and its relative activities on medium and long chain triglycerides.
LIPFDGKA might serve as a potential possible biomarkers for diagnosis of gastric cancer, and their downregulation may bring new perspective into the investigation of gastric cancer prognosis
In patients with intrahepatic cholestasis of pregnancy, there was no elevation in LIPF mRNA in maternal circulation compared with controls.
Recombinant human gastric lipase (hGL) was transiently expressed in Nicotiana benthamiana leaves using the CPMV-HT expression system.
insights into the domain movements
down-regulated KLF4, CHGA, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA is an 8-gene signature for gastric cancer
Mechanisms of inhibition of triacylglycerol hydrolysis
identidfied the cap and the lid residues involved in the binding with the lipidic substrate
This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene.
lysosomal acid lipase/cholesteryl ester hydrolase
, lipase, gastric
, gastric triacylglycerol lipase-like
, gastric lipase
, gastric triacylglycerol lipase
, lingual lipase
, lipase F
, prelingual lipase
, triacylglycerol lipase
, pregastric esterase