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LYNX1 encodes a member of the Ly-6/neurotoxin gene family, a group of lymphocyte antigens that attach to the cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine residues with a characteristic spacing pattern. Additionally we are shipping Ly6/neurotoxin 1 Proteins (7) and many more products for this protein.
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results show that some functional and behavioral aspects of alpha6-nAChRs are modulated by lynx1
These findings provide new insights into the acetylcholine receptor-mediated regulatory mechanism of SLURP-2 expression in keratinocytes.
These studies suggest that lynx1 is a potential target both for development of drugs that may limit lung cancer growth as well as for drugs that may be effective for asthma or COPD treatment.
This epigenome-wide DNA methylation analysis in postmortem hippocampus and prefrontal cortex specimens confirmed LYNX1 DNA methylation profiles in major depression.
Micromolar affinities and fast washout rates measured for ws-LYNX1 and its mutants are in contrast to nanomolar affinities and irreversibility of binding for alpha-bungarotoxin and similar snake alpha-neurotoxins also targeting alpha7 nAChR.
Computer modeling, based on ws-LYNX1 NMR structure and AChBP x-ray structure, revealed a possible mode of ws-LYNX1 binding.
LY-6K,a novel member protein of the Ly-6/uPAR superfamily, is a significant new molecular marker for diagnosis and gene therapy in patients with breast cancer.
decreased Lynx1 is associated with squamous cell lung carcinoma
LY-6K meaningfully participates in breast cancer cell metastasis
Lynx1 appears to act as a negative modulator of alpha7 nAChR-induced events by inhibiting Src activation.
This gene encodes a member of the Ly-6/neurotoxin gene family, a group of lymphocyte antigens that attach to the cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine residues with a characteristic spacing pattern. Functional analysis indicates that this protein is not a ligand or neurotransmitter but has the capacity to enhance nicotinic acetylcholine receptor function in the presence of acetylcholine. This gene may also play a role in the pathogenesis of psoriasis vulgaris. Alternatively spliced variants encoding different isoforms have been identified.
, ly-6/neurotoxin-like protein 1
, secreted Ly-6/uPAR domain-containing protein 2
, secreted Ly-6/uPAR-related protein 2
, Ly-6 neurotoxin-like protein 1
, secreted Ly6/uPAR related protein 2