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Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009].. Additionally we are shipping KDM1B Proteins (3) and many more products for this protein.
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Human Polyclonal KDM1B Primary Antibody for ICC, IF - ABIN4280857
Katz, Vasilatos, Harrington, Oesterreich, Davidson, Huang: Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells. in Breast cancer research and treatment 2014
These results demonstrate an important role for LSD2 in regulation of DNA methylation (show HELLS Antibodies) and gene silencing in breast cancer.
Histone demethylase (show MBD2 Antibodies) LSD2 acts as an E3 ubiquitin ligase (show MUL1 Antibodies) and inhibits cancer cell growth through promoting proteasomal degradation of OGT (show OGT Antibodies).
Using transcriptome and chromatin immunoprecipitation-sequencing analyses, the study revealed that LSD2 represses the genes involved in lipid influx and metabolism through demethylation of histone H3K4.
regulation of tissue factor pathway inhibitor-2 (TFPI-2 (show TFPI2 Antibodies)) expression by lysine-specific demethylase (show MBD2 Antibodies) 1 and 2
The zinc finger-SWIRM-oxidase domains is required for KDM1B demethylase (show MBD2 Antibodies) activity and the binding of FAD (show BRCA2 Antibodies).
Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.
reveal a direct role of hypoxia-inducible factor in regulating miRNA biogenesis and consequently activating the miR (show MLXIP Antibodies)-215-KDM1B-mediated signaling required for glioma-initiating cells adaptation to hypoxia
Data indicate that Myst4 (show KAT6B Antibodies), Jmjd2b (show KDM4B Antibodies), Aof1 genes are regulated by H3K9me under hyperinsulinemia/hyperglycemia.
AOF1 is the second histone demethylase (show MBD2 Antibodies) in the family of flavin-dependent amine oxidases and reveals a demethylase (show MBD2 Antibodies)-independent repression function.
oocytes from KDM1B-deficient females showed a substantial increase in H3K4 methylation and failed to set up the DNA methylation (show HELLS Antibodies) marks at four out of seven imprinted genes examined
Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009
amine oxidase (flavin containing) domain 1
, lysine (K)-specific demethylase 1B
, lysine-specific histone demethylase 1B-like
, amine oxidase, flavin containing 1
, flavin-containing amine oxidase domain-containing protein 1
, lysine-specific histone demethylase 1B
, lysine-specific histone demethylase 2